NURS 305
Pharmacology
COMPREHENSIVE FINALS
EXAM
Q&S
©2024/2025
,1. Which of the following is a primary mechanism of action for
selective serotonin reuptake inhibitors (SSRIs)?
a) Inhibition of monoamine oxidase
b) Blockade of dopamine receptors
c) Inhibition of serotonin reuptake transporter
d) Stimulation of adrenergic receptors
Answer: c) Inhibition of serotonin reuptake transporter
Rationale: SSRIs are designed to prevent the reuptake of
serotonin into the pre-synaptic neuron, increasing its availability
in the synaptic cleft.
2. Which phase of pharmacokinetics involves the
transformation of a drug into more water-soluble compounds for
excretion?
a) Absorption
b) Distribution
c) Metabolism
d) Excretion
Answer: c) Metabolism
Rationale: Metabolism typically transforms lipophilic drug
compounds into hydrophilic forms to facilitate excretion.
3. What class of drugs does Losartan belong to?
a) Calcium channel blockers
b) ACE inhibitors
c) Beta-blockers
d) Angiotensin II receptor blockers (ARBs)
Answer: d) Angiotensin II receptor blockers (ARBs)
Rationale: Losartan is an ARB, which helps manage blood
©2024/2025
, pressure by blocking angiotensin II effects.
4. The therapeutic effect of beta-1 selective blockers is primarily
associated with which action?
a) Bronchodilation
b) Vasodilation
c) Reduction of heart rate and contractility
d) Stimulation of insulin release
Answer: c) Reduction of heart rate and contractility
Rationale: Beta-1 selective blockers primarily affect cardiac
tissues, reducing heart rate and force of contraction.
5. Which of the following agents is used as an antidote for
acetaminophen overdose?
a) Atropine
b) Activated charcoal
c) N-acetylcysteine
d) Flumazenil
Answer: c) N-acetylcysteine
Rationale: N-acetylcysteine acts as a precursor to glutathione,
detoxifying NAPQI, the toxic metabolite of acetaminophen.
### Fill-in-the-Blank Questions
6. __________ is the term for the time required to reduce the
plasma concentration of a drug by half.
Answer: Half-life
Rationale: Half-life is a pharmacokinetic parameter key to
understanding drug dosing intervals and accumulation.
7. Cytochrome P450 enzymes primarily involved in drug
©2024/2025
Pharmacology
COMPREHENSIVE FINALS
EXAM
Q&S
©2024/2025
,1. Which of the following is a primary mechanism of action for
selective serotonin reuptake inhibitors (SSRIs)?
a) Inhibition of monoamine oxidase
b) Blockade of dopamine receptors
c) Inhibition of serotonin reuptake transporter
d) Stimulation of adrenergic receptors
Answer: c) Inhibition of serotonin reuptake transporter
Rationale: SSRIs are designed to prevent the reuptake of
serotonin into the pre-synaptic neuron, increasing its availability
in the synaptic cleft.
2. Which phase of pharmacokinetics involves the
transformation of a drug into more water-soluble compounds for
excretion?
a) Absorption
b) Distribution
c) Metabolism
d) Excretion
Answer: c) Metabolism
Rationale: Metabolism typically transforms lipophilic drug
compounds into hydrophilic forms to facilitate excretion.
3. What class of drugs does Losartan belong to?
a) Calcium channel blockers
b) ACE inhibitors
c) Beta-blockers
d) Angiotensin II receptor blockers (ARBs)
Answer: d) Angiotensin II receptor blockers (ARBs)
Rationale: Losartan is an ARB, which helps manage blood
©2024/2025
, pressure by blocking angiotensin II effects.
4. The therapeutic effect of beta-1 selective blockers is primarily
associated with which action?
a) Bronchodilation
b) Vasodilation
c) Reduction of heart rate and contractility
d) Stimulation of insulin release
Answer: c) Reduction of heart rate and contractility
Rationale: Beta-1 selective blockers primarily affect cardiac
tissues, reducing heart rate and force of contraction.
5. Which of the following agents is used as an antidote for
acetaminophen overdose?
a) Atropine
b) Activated charcoal
c) N-acetylcysteine
d) Flumazenil
Answer: c) N-acetylcysteine
Rationale: N-acetylcysteine acts as a precursor to glutathione,
detoxifying NAPQI, the toxic metabolite of acetaminophen.
### Fill-in-the-Blank Questions
6. __________ is the term for the time required to reduce the
plasma concentration of a drug by half.
Answer: Half-life
Rationale: Half-life is a pharmacokinetic parameter key to
understanding drug dosing intervals and accumulation.
7. Cytochrome P450 enzymes primarily involved in drug
©2024/2025
