CELL INJURY
CELL DEATH
, OBJECTIVES
Understand the 3 main anatomic concepts of
disease---Degenerative, Inflammatory,
Neoplastic
Understand the concepts of cellular growth
adaptations---Hyperplasia, Hypertrophy,
Atrophy, Metaplasia
Understand the factors of cell injury and
death---O2, Physical, Chemical, Infection,
Immunologic, Genetic, Nutritional
, OBJECTIVES
Understand the pathologic mechanisms at
the SUB-cellular level---ATP,
Mitochondria, Ca++, Free Radicals,
Membranes
Understand and differentiate the concepts
of APOPTOSIS and NECROSIS
Understand SUB-cellular responses to
injury---Lysosomes, Smooth endoplasmic
reticulum, Mitochondria, Cytoskeleton
, OBJECTIVES
Identify common INTRA-cellular
accumulations---Fat, Hyaline,
CA++, Proteins, Glycogen,
Pigments
Understand aging and differentiate
the concepts of preprogrammed
death versus wear and tear.