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Psoriasis treatment Exam Questions and Answers

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Three initial treatments for Psoriasis - Answer-moisturizers - minimize water evaporation keratolytics - remove scales, smooth skin Ex: salicylic acid: exfolaites small areas Emolients - coal tar (if localized) Calcipotriene - Answer-mechanism: vitamin D analogue, inhibits cell proliferation and differentiation - as effective as medium steroid side effects: mild burning, sting of lesion and around lesion, dry skin, facial irritation Pregnancy category C Tazarotene - Answer-mechanism: topical retinoid, increase cell turnover, is synergistic with corticosteroids side effects: erythema, burning, peeling, pruritis Pregnancy X Topical steroids - Answer-mechanism: inhibits epidermal cell mitosis, decreases erythema, pruritis, scaling (inhibits phsophlipase A) tolerance can develop with long term use mild to moderate are safe in pregnancy Low potency steroid - Answer-modest anti-inflammatory effect safe for long term use Alcometasone, Desonide, Hydrocortisone, Fluccinolone Medium potency steroid - Answer-for moderate inflammatory dermatoses can be used limited on the face Betamethoasone dipropionate, clocortolone pivalate, desoximetason, fluticasone

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Psoriasis treatment Exam Questions and
Answers
Three initial treatments for Psoriasis - Answer-moisturizers - minimize water evaporation

keratolytics - remove scales, smooth skin
Ex: salicylic acid: exfolaites small areas

Emolients - coal tar (if localized)

Calcipotriene - Answer-mechanism: vitamin D analogue, inhibits cell proliferation and
differentiation

- as effective as medium steroid

side effects: mild burning, sting of lesion and around lesion, dry skin, facial irritation

Pregnancy category C

Tazarotene - Answer-mechanism: topical retinoid, increase cell turnover, is synergistic
with corticosteroids

side effects: erythema, burning, peeling, pruritis

Pregnancy X

Topical steroids - Answer-mechanism: inhibits epidermal cell mitosis, decreases
erythema, pruritis, scaling (inhibits phsophlipase A)

tolerance can develop with long term use

mild to moderate are safe in pregnancy

Low potency steroid - Answer-modest anti-inflammatory effect

safe for long term use

Alcometasone, Desonide, Hydrocortisone, Fluccinolone

Medium potency steroid - Answer-for moderate inflammatory dermatoses

can be used limited on the face

Betamethoasone dipropionate, clocortolone pivalate, desoximetason, fluticasone

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