Cancer pharmacology
Oncogenes vs. Tumor suppressor genes
Oncogenes - pressure most cancers progression; expanded in cancers
Tumor suppressors - inhibit cancer development ; decreased in cancers
Normal DNA replication introduces about __________ mutations per cellular every day
20 K
Previous
Play
Next
Rewind 10 seconds
Move forward 10 seconds
Unmute
0:01
/
0:15
Full screen
Brainpower
Read More
List all CAUSES of most cancers:
-Increase in oncogene interest
-Decrease in tumor suppressor interest
-Inherited mutation
-Mutations in DNA
-VIRUS (e.G. HPV)
four Main categories of Cancer therapy:
1. Surgery
2. Radiation
3. Chemotherapy
(four. Palliative care)
,Most of the drug goals for Cancer is (Oncogenes / Tumor suppressor genes). Why?
Oncogenes ;
-b/c it's easier to inhibit the oncogenes, rather than trying to FIX the dysfunctional tumor
suppressors
"It's less difficult to break some thing with a drug, than to fix sth"
Mutations in ___________ genes predispose individuals to breast most cancers
BRCA 1/ 2
Surgery works first-rate when you have ____________ cancer.
Localized
(vs. Disseminated)
Meaning of "Debulking prior to other remedies"
a.K.A. Neoadjuvant therapy
-Taking out majority of tumor in debulking technique and then the use of different styles of
remedy to cast off residual ailment, once you get the huge bite of hassle out.
(debulking can be executed with the aid of both surgical treatment or radiation)
______________ is known as remedy given as 1st step to reduce tumor earlier than the
principle treatment.
Neoadjuvant remedy
______________ form of cancer remedy is utilized in greater than 50% of sufferers
Radiation
, Neoadjuvant vs Adjuvant remedy:
Neoadjuvant:
-cancer remedy regarding "debulking" where the majority of tumor is eliminated first.
Adjuvant:
-After the Neoadjuvant remedy or surgical treatment, residual ailment is eliminated for entire
efficacy of cancer remedy
External vs Internal Radiation therapy:
External - focusing radiation at the tumor
Internal - regularly involves implantation of beads that emit radiation internally (e.G. Thyroid,
prostate cancer)
______________ form of cancer remedy is most effective for disseminated disorder
systemic Chemotherapy
Systemic chemotherapy:
-lets in the drug to move at some stage in the complete body --> even unmarried cell tumor that
is hiding may be removed earlier than turning into metastatic
(T/F) In Metastatic cancers, chemotherapy can commonly be curative.
FALSE;
It's usually just life-extending, once it's gotten metastatic.
____________ is a care given to enhance first-rate of life and enlarge lives of humans w/
terminal illnesses
Palliative care
Once the cancer becomes _____________, chemotherapy can't turn out to be curative.
Oncogenes vs. Tumor suppressor genes
Oncogenes - pressure most cancers progression; expanded in cancers
Tumor suppressors - inhibit cancer development ; decreased in cancers
Normal DNA replication introduces about __________ mutations per cellular every day
20 K
Previous
Play
Next
Rewind 10 seconds
Move forward 10 seconds
Unmute
0:01
/
0:15
Full screen
Brainpower
Read More
List all CAUSES of most cancers:
-Increase in oncogene interest
-Decrease in tumor suppressor interest
-Inherited mutation
-Mutations in DNA
-VIRUS (e.G. HPV)
four Main categories of Cancer therapy:
1. Surgery
2. Radiation
3. Chemotherapy
(four. Palliative care)
,Most of the drug goals for Cancer is (Oncogenes / Tumor suppressor genes). Why?
Oncogenes ;
-b/c it's easier to inhibit the oncogenes, rather than trying to FIX the dysfunctional tumor
suppressors
"It's less difficult to break some thing with a drug, than to fix sth"
Mutations in ___________ genes predispose individuals to breast most cancers
BRCA 1/ 2
Surgery works first-rate when you have ____________ cancer.
Localized
(vs. Disseminated)
Meaning of "Debulking prior to other remedies"
a.K.A. Neoadjuvant therapy
-Taking out majority of tumor in debulking technique and then the use of different styles of
remedy to cast off residual ailment, once you get the huge bite of hassle out.
(debulking can be executed with the aid of both surgical treatment or radiation)
______________ is known as remedy given as 1st step to reduce tumor earlier than the
principle treatment.
Neoadjuvant remedy
______________ form of cancer remedy is utilized in greater than 50% of sufferers
Radiation
, Neoadjuvant vs Adjuvant remedy:
Neoadjuvant:
-cancer remedy regarding "debulking" where the majority of tumor is eliminated first.
Adjuvant:
-After the Neoadjuvant remedy or surgical treatment, residual ailment is eliminated for entire
efficacy of cancer remedy
External vs Internal Radiation therapy:
External - focusing radiation at the tumor
Internal - regularly involves implantation of beads that emit radiation internally (e.G. Thyroid,
prostate cancer)
______________ form of cancer remedy is most effective for disseminated disorder
systemic Chemotherapy
Systemic chemotherapy:
-lets in the drug to move at some stage in the complete body --> even unmarried cell tumor that
is hiding may be removed earlier than turning into metastatic
(T/F) In Metastatic cancers, chemotherapy can commonly be curative.
FALSE;
It's usually just life-extending, once it's gotten metastatic.
____________ is a care given to enhance first-rate of life and enlarge lives of humans w/
terminal illnesses
Palliative care
Once the cancer becomes _____________, chemotherapy can't turn out to be curative.
