MMSC491 Exam 3- Questions and Answers
What is a major source of aneuploidies in cancer cells? Correct Ans-Defects in spindle
checkpoints
Which of the following statements DOES NOT describe a role of the p53 protein? Correct
Ans-P53 promotes cell growth
The term angiogenesis refers to what aspect of cancer progression? Correct Ans-Sprouting
of existing blood vessels to connect the tumor to existing vasculature
A primary lung adenocarcinoma has metastasized to the liver? What type of cell would be
expected to be found in the tumors found in the liver? Correct Ans-Liver epithelial cells
Name the fundamental classes of cancer genes Correct Ans-Oncogenes and tumor
suppressors
Gene amplification is a common characteristic of HER - positive breast cancer. Which of the
following statements describes the expected copy number of the Her -2 gene in breast cancer
cells relative to respect to normal cells? Correct Ans-The copy number would be expected
to be higher in cancer cells
Genetic alterations are considered the major drivers in many cancers. Consider the image
shown below. The image shows fluorescent in situ hybridization (FISH ) using a MYCN gene
probe (pinkish-red signals) against a general background of DNA staining shown in blue. Each
, MMSC491 Exam 3- Questions and Answers
blue circular area represents an individual cell. What type of cancer- associated genetic
alteration of MYCN is most likely illustrated in the image below ? Correct Ans-Gene
amplification
What is the most appropriate gene therapy for treating cancer?
a. Repair of mutant gene
b. Modifying disease cells
c. Killing disease cells
d. Gene augmentation Correct Ans-Killing disease cells
How do cancer cells avoid chromosome destabilization due to their rapidly shortening
telomeres? Correct Ans-They express telomerase
In cancer cells, hypomethylation of DNA results in... Correct Ans-None of the above
Which of the following databases contains descriptions of genomic, transcriptomic, and
epigenetic changes in different types of tumors? Correct Ans-ICGC
Which of the following discoveries in cancer research is a direct result of the advent of next-
generation sequencing? Correct Ans-Extraordinary mutational diversity in tumors
Which of the following is not a method of oncogene activation? Correct Ans-RAS/RAF
pathway activation
What is a major source of aneuploidies in cancer cells? Correct Ans-Defects in spindle
checkpoints
Which of the following statements DOES NOT describe a role of the p53 protein? Correct
Ans-P53 promotes cell growth
The term angiogenesis refers to what aspect of cancer progression? Correct Ans-Sprouting
of existing blood vessels to connect the tumor to existing vasculature
A primary lung adenocarcinoma has metastasized to the liver? What type of cell would be
expected to be found in the tumors found in the liver? Correct Ans-Liver epithelial cells
Name the fundamental classes of cancer genes Correct Ans-Oncogenes and tumor
suppressors
Gene amplification is a common characteristic of HER - positive breast cancer. Which of the
following statements describes the expected copy number of the Her -2 gene in breast cancer
cells relative to respect to normal cells? Correct Ans-The copy number would be expected
to be higher in cancer cells
Genetic alterations are considered the major drivers in many cancers. Consider the image
shown below. The image shows fluorescent in situ hybridization (FISH ) using a MYCN gene
probe (pinkish-red signals) against a general background of DNA staining shown in blue. Each
, MMSC491 Exam 3- Questions and Answers
blue circular area represents an individual cell. What type of cancer- associated genetic
alteration of MYCN is most likely illustrated in the image below ? Correct Ans-Gene
amplification
What is the most appropriate gene therapy for treating cancer?
a. Repair of mutant gene
b. Modifying disease cells
c. Killing disease cells
d. Gene augmentation Correct Ans-Killing disease cells
How do cancer cells avoid chromosome destabilization due to their rapidly shortening
telomeres? Correct Ans-They express telomerase
In cancer cells, hypomethylation of DNA results in... Correct Ans-None of the above
Which of the following databases contains descriptions of genomic, transcriptomic, and
epigenetic changes in different types of tumors? Correct Ans-ICGC
Which of the following discoveries in cancer research is a direct result of the advent of next-
generation sequencing? Correct Ans-Extraordinary mutational diversity in tumors
Which of the following is not a method of oncogene activation? Correct Ans-RAS/RAF
pathway activation
