PBSC Pharmacology
Hydantoin Prototype for Seizures – answer Pheytoin (Dilatin)
Phenytoin (Dilantin) Adverse Effects – answer CNS depression (don't use in elderly),
gingival hyperplasia, rash, dysrhythmias, hypertension, Cat. D
Anxiolytic Benzodiazepine Prototype - answer Lorazepam (Ativan)
Lorazepam (Ativan) Adverse Effects - answer drowsiness, dizziness, ataxia (FALL
RISK), respiratory depression (Keep in Fowlers position)
Phenothiazine Antipsychotic Prototype (typical) - answer Chlorpromazine (Thorazine)
Chlorpromazine (Thorazine) Adverse Effects - answer All EPS's, NMS, increased death
risk in elderly, sexual dysfunction
Hydantoin action - answer desensitizes Na channels
Benzodiazepine action - answer intensifies GABA
Phenothiazine action - answer blocks dopamine
No phenothiazine Antipsychotic Prototype (typical) – answer Halperidol(Haldol)
Halperidol(Haldol) AE's - answerEMS's, NMS, less sedation than phenothiazines,
sexual dysfunction, increased death risk in elderly
Nonphenthiazine action - answer blocks dopamine type 2 receptor
Atypical antipsychotic Prototype – answer Risperdine(Risperdol)
Risperidone (Risperdol) AE's - answerEPS's, NMS, orthostatic hypotension, weight
gain, glucose metab problem in diabetics
Atypical antipsychotic action - answerblocks dopamine, serotonin, and alpha adrenergic
receptors
Atypical SNRI antidepressant (no prototype) - answerDuloxetine (Cymbalta)
, Duloxetine (Cymbalta) AE's - answertakes 4 weeks to start seeing benefits, nausea,
suicide ideation, decreased libido, insomnia, weight loss, constipation, dry mouth,
headache, fatigue
SNRI action - answerinhibits reabsorption of serotonin and NE, causing increased
amounts
TCA prototype - answerImpramine(Tofranil)
Impramine (tofranil) AE's - answerorthostatic hypotension, sedation, anticholinergic,
suicide ideation
TCA action - answerinhibits reuptake of NE and serotonin
MAOI antidepressant Prototype - answerPhenelzine(Nardil)
Phenelzine (nardil) AE's - answerorthostatic hypotension, headache, insomnia,
constipation, suicide ideation, hypersensitive crisis if mixed with antidepressants,
serotonin syndrome, hypotension if mixed with antihypertensives
SSRI antidepression Prototype - answer(SAFEST CLASS) Sertralline (Zoloft)
Srtralline(Zoloft) AE's - answersexual dysfunction, nausea, headache, weight gain,
anxiety, insomnia, suicide ideation
Dopamine Hydrochloride treats - answercardiogenic shock/hypovolemia, increases
renal blood flow, BP, urine output. CATECHOLAMINE(Adrenergic agonist)
Phenytoin Prototype for seizures - answerValproic Acid (Depakene)
Valproic Acid (Depakene) AE's - answerCNS Depression, sedation, drowsiness, ataxia,
GI upset, prolonged bleeding time, CAT D
phenytoin action - answersuppresses Na
benzodiazepine Prototype for seizures - answerDiazepam (valium)
Diazepam (Valium) AE's - answerdrowsiness, dizziness, respiratory depression w/ other
depressants
Benzodiazipine actions - answerstimulates gaba, safer than barbituates
Anxiolytic SSRI Prototype - answerEscitalopram Oxalate (Lexapro)
Escitalopram Oxalate (Lexapro) AE's - answerdizziness, insomnia, somnolence, sexual
dysfunction, confusion, seizures if OD
Hydantoin Prototype for Seizures – answer Pheytoin (Dilatin)
Phenytoin (Dilantin) Adverse Effects – answer CNS depression (don't use in elderly),
gingival hyperplasia, rash, dysrhythmias, hypertension, Cat. D
Anxiolytic Benzodiazepine Prototype - answer Lorazepam (Ativan)
Lorazepam (Ativan) Adverse Effects - answer drowsiness, dizziness, ataxia (FALL
RISK), respiratory depression (Keep in Fowlers position)
Phenothiazine Antipsychotic Prototype (typical) - answer Chlorpromazine (Thorazine)
Chlorpromazine (Thorazine) Adverse Effects - answer All EPS's, NMS, increased death
risk in elderly, sexual dysfunction
Hydantoin action - answer desensitizes Na channels
Benzodiazepine action - answer intensifies GABA
Phenothiazine action - answer blocks dopamine
No phenothiazine Antipsychotic Prototype (typical) – answer Halperidol(Haldol)
Halperidol(Haldol) AE's - answerEMS's, NMS, less sedation than phenothiazines,
sexual dysfunction, increased death risk in elderly
Nonphenthiazine action - answer blocks dopamine type 2 receptor
Atypical antipsychotic Prototype – answer Risperdine(Risperdol)
Risperidone (Risperdol) AE's - answerEPS's, NMS, orthostatic hypotension, weight
gain, glucose metab problem in diabetics
Atypical antipsychotic action - answerblocks dopamine, serotonin, and alpha adrenergic
receptors
Atypical SNRI antidepressant (no prototype) - answerDuloxetine (Cymbalta)
, Duloxetine (Cymbalta) AE's - answertakes 4 weeks to start seeing benefits, nausea,
suicide ideation, decreased libido, insomnia, weight loss, constipation, dry mouth,
headache, fatigue
SNRI action - answerinhibits reabsorption of serotonin and NE, causing increased
amounts
TCA prototype - answerImpramine(Tofranil)
Impramine (tofranil) AE's - answerorthostatic hypotension, sedation, anticholinergic,
suicide ideation
TCA action - answerinhibits reuptake of NE and serotonin
MAOI antidepressant Prototype - answerPhenelzine(Nardil)
Phenelzine (nardil) AE's - answerorthostatic hypotension, headache, insomnia,
constipation, suicide ideation, hypersensitive crisis if mixed with antidepressants,
serotonin syndrome, hypotension if mixed with antihypertensives
SSRI antidepression Prototype - answer(SAFEST CLASS) Sertralline (Zoloft)
Srtralline(Zoloft) AE's - answersexual dysfunction, nausea, headache, weight gain,
anxiety, insomnia, suicide ideation
Dopamine Hydrochloride treats - answercardiogenic shock/hypovolemia, increases
renal blood flow, BP, urine output. CATECHOLAMINE(Adrenergic agonist)
Phenytoin Prototype for seizures - answerValproic Acid (Depakene)
Valproic Acid (Depakene) AE's - answerCNS Depression, sedation, drowsiness, ataxia,
GI upset, prolonged bleeding time, CAT D
phenytoin action - answersuppresses Na
benzodiazepine Prototype for seizures - answerDiazepam (valium)
Diazepam (Valium) AE's - answerdrowsiness, dizziness, respiratory depression w/ other
depressants
Benzodiazipine actions - answerstimulates gaba, safer than barbituates
Anxiolytic SSRI Prototype - answerEscitalopram Oxalate (Lexapro)
Escitalopram Oxalate (Lexapro) AE's - answerdizziness, insomnia, somnolence, sexual
dysfunction, confusion, seizures if OD
