HDFN Final Exam 1 Questions And 100% Correct Answers
In 1939, _________________ and _____________________ postulated the immunization of a
mother to paternal antigen carried on fetus/newborn's RBCs - ANSWER Levine + Stetson
Maternal antibodies can be stimulated by these 3 things.
1. prior ______________________
2. prior/current _____________________
3. occcassionally during the ___________ of ____________ trimester of pregnancy -
ANSWER 1. pregnancy
2. transfusion
3. second + third
____________________________________ is an immune response to foreign / non-self
antigens from another human. Foreign RBCs containing these antigens can stimulate
production of corresponding Abs. Can you provide an example? - ANSWER
Alloimmunization / Ex: fetal RBCs leak (hemorrhage) into maternal circulation
T or F. Alloimmunization in HDFN is due to anti-D only. - ANSWER F, it may be due to
anti-D and even anti-K
HDFN due to anti-k causes supression of _______________________ ______________________
(f.e.) as well as _____________________ (h) - ANSWER fetal erythropoiesis + hemolysis
T or F, both IgM and IgG are capable of causing HDFN. - ANSWER F, only IgG has the
potential to cause HDFN; most cause mild to moderate disease
Common Antibodies in causing HDN? - ANSWER anti-D, anti-D+C, anti-D+E, anti-C,
anti-E, anti-c, anti-e, anti-K
, Rare Antibodies in causing HDN? - ANSWER anti-Fya, anti-s, anti-S, anti-M, anti-N
These antibodies never cause HDN. - ANSWER anti-Le^a, anti-Le^b, anti-I, anti-IH,
anti-P1
T or F. Lewis antibodies can cause HDFN. - ANSWER F, anti-Le a or b can never cause
HDFN
HDFN - Pathogenesis
T or F. Exposure to fetal RBCs an alloimmunization occur.early in pregnacny - ANSWER
F, .late in pregnancy and at delivery
HDFN - Pathogenesis
T or F, fetus/newborn of the first pregnancy are often affected by HDFN - ANSWER F,
they are rarely affected
HDFN - Pathogenesis
1. Fetal ___________ leak into the maternal ____________________ inducing a immune
response from the mother's _______ cells - ANSWER RBCs + circulation + B
HDFN - Pathogenesis
2. Maternal ___________ cross the _______________ into the fetal ___________________ -
ANSWER Abs + placenta + circulation
HDFN - Pathogenesis
3. Maternal Abs in the fetal circulation bind to stimulating __________ - ANSWER Ag
HDFN - Pathogenesis
In 1939, _________________ and _____________________ postulated the immunization of a
mother to paternal antigen carried on fetus/newborn's RBCs - ANSWER Levine + Stetson
Maternal antibodies can be stimulated by these 3 things.
1. prior ______________________
2. prior/current _____________________
3. occcassionally during the ___________ of ____________ trimester of pregnancy -
ANSWER 1. pregnancy
2. transfusion
3. second + third
____________________________________ is an immune response to foreign / non-self
antigens from another human. Foreign RBCs containing these antigens can stimulate
production of corresponding Abs. Can you provide an example? - ANSWER
Alloimmunization / Ex: fetal RBCs leak (hemorrhage) into maternal circulation
T or F. Alloimmunization in HDFN is due to anti-D only. - ANSWER F, it may be due to
anti-D and even anti-K
HDFN due to anti-k causes supression of _______________________ ______________________
(f.e.) as well as _____________________ (h) - ANSWER fetal erythropoiesis + hemolysis
T or F, both IgM and IgG are capable of causing HDFN. - ANSWER F, only IgG has the
potential to cause HDFN; most cause mild to moderate disease
Common Antibodies in causing HDN? - ANSWER anti-D, anti-D+C, anti-D+E, anti-C,
anti-E, anti-c, anti-e, anti-K
, Rare Antibodies in causing HDN? - ANSWER anti-Fya, anti-s, anti-S, anti-M, anti-N
These antibodies never cause HDN. - ANSWER anti-Le^a, anti-Le^b, anti-I, anti-IH,
anti-P1
T or F. Lewis antibodies can cause HDFN. - ANSWER F, anti-Le a or b can never cause
HDFN
HDFN - Pathogenesis
T or F. Exposure to fetal RBCs an alloimmunization occur.early in pregnacny - ANSWER
F, .late in pregnancy and at delivery
HDFN - Pathogenesis
T or F, fetus/newborn of the first pregnancy are often affected by HDFN - ANSWER F,
they are rarely affected
HDFN - Pathogenesis
1. Fetal ___________ leak into the maternal ____________________ inducing a immune
response from the mother's _______ cells - ANSWER RBCs + circulation + B
HDFN - Pathogenesis
2. Maternal ___________ cross the _______________ into the fetal ___________________ -
ANSWER Abs + placenta + circulation
HDFN - Pathogenesis
3. Maternal Abs in the fetal circulation bind to stimulating __________ - ANSWER Ag
HDFN - Pathogenesis
