100% Correct!!
Doxorubicin - ANSWERCardiotoxic
TISSUE VESICANT
Baseline MUGA and total dose (CONCERN at 550 mg/m2)
URINE=RED
IF EXTRAVASATION OCCURS= cool/ice + Totect
Idamycin - ANSWERCardiotoxic (cardiomyopathy)
Bleomycin - ANSWERAVOID oxygen supplementation
Methotrexate - ANSWER*Leukovorin decreases cytotoxicity*
Pemetrexed - ANSWERVitamin B12 & folic acid supplements to decrease toxicity
Fludarabine - ANSWERImmunosuppression
Thioguanine - ANSWERBone Marrow Suppression
Stomatitis/Mucositis
5-FU - ANSWER*Stomatitis
Bone marrow depression
*Diarrhea
Mucositis
Capeticibine - ANSWER***Pro-drug that converts 5FU in liver
Stomatitis & mucositis
Palmar-plantar erythrodysthesias (hand foot syndrome)
Cytarabine or Cytosine Arabinoside - ANSWERCerebellar neurotoxicity
Gemcitabine - ANSWERRadiosensitizer DO NOT GIVE W/ RADIATION, except at very low doses
Carmustine - ANSWER***Solvent is alcohol
Alcohol sensivity is an issue
Mix ONLY in 0.9% NaCl
Carboplatin - ANSWERDose by CALVERT formula
Allergic reaction increased from 1-27% in pts receiving >6-7 courses