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Chemotherapy Certification Exam 100% Correct!!

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Doxorubicin - ANSWERCardiotoxic TISSUE VESICANT Baseline MUGA and total dose (CONCERN at 550 mg/m2) URINE=RED IF EXTRAVASATION OCCURS= cool/ice + Totect Idamycin - ANSWERCardiotoxic (cardiomyopathy) Bleomycin - ANSWERAVOID oxygen supplementation Methotrexate - ANSWER*Leukovorin decreases cytotoxicity* Pemetrexed - ANSWERVitamin B12 & folic acid supplements to decrease toxicity Fludarabine - ANSWERImmunosuppression Thioguanine - ANSWERBone Marrow Suppression Stomatitis/Mucositis 5-FU - ANSWER*Stomatitis

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Chemotherapy Certification Exam
100% Correct!!

Doxorubicin - ANSWERCardiotoxic

TISSUE VESICANT

Baseline MUGA and total dose (CONCERN at 550 mg/m2)

URINE=RED

IF EXTRAVASATION OCCURS= cool/ice + Totect

Idamycin - ANSWERCardiotoxic (cardiomyopathy)

Bleomycin - ANSWERAVOID oxygen supplementation

Methotrexate - ANSWER*Leukovorin decreases cytotoxicity*

Pemetrexed - ANSWERVitamin B12 & folic acid supplements to decrease toxicity

Fludarabine - ANSWERImmunosuppression

Thioguanine - ANSWERBone Marrow Suppression

Stomatitis/Mucositis

5-FU - ANSWER*Stomatitis

Bone marrow depression

*Diarrhea

Mucositis

Capeticibine - ANSWER***Pro-drug that converts 5FU in liver

Stomatitis & mucositis

Palmar-plantar erythrodysthesias (hand foot syndrome)

Cytarabine or Cytosine Arabinoside - ANSWERCerebellar neurotoxicity

Gemcitabine - ANSWERRadiosensitizer DO NOT GIVE W/ RADIATION, except at very low doses

Carmustine - ANSWER***Solvent is alcohol

Alcohol sensivity is an issue

Mix ONLY in 0.9% NaCl

Carboplatin - ANSWERDose by CALVERT formula

Allergic reaction increased from 1-27% in pts receiving >6-7 courses

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