BCPP Review part 1
ADRs of ketamine - correct answer ✔✔ADRs include GI, Sedation, BP increase, Dissociation, Urinary
frequency/incontinence, Cognitive/motor impairment
ADRs of trazodone - correct answer ✔✔ADRs include GI, Sedation, Dry mouth, Orthostatic hypotension,
Headache, Priapism
ADRs of mirtazapine - correct answer ✔✔ADRs include Sedation, Dry mouth, Appetite increase,
Increased TGs
ADRs of bupropion - correct answer ✔✔ADRs include GI, Dry mouth, Headache, Insomnia, Anxiety,
Hypertension, Tachyarrhythmias
MOA of vortioxetine - correct answer ✔✔5HT reuptake inhibition, 5HT3 antagonism, 5HT1A agonism,
5HT1B partial agonism
MOA of trazodone - correct answer ✔✔5HT and NE reuptake inhibition (weak), Alpha-1 blocker (weak),
5HT2A antagonism, Histamine 1 antagonism
MOA of vilazodone - correct answer ✔✔5HT reuptake inhibition, 5HT1A partial agonist
MOA of mirtazapine - correct answer ✔✔Alpha 2 agonism, 5HT2 and 5HT3 antagonist, Histamine 1
antagonist
ADR of antidepressants in children - correct answer ✔✔Anxiety, irritability, akathisia, behavior changes,
SI
Preferred antidepressants to AVOID in pregnancy - correct answer ✔✔paroxetine, venlafaxine, doxepin
, Preferred antidepressants in lactation - correct answer ✔✔paroxetine, sertraline
Preferred antidepressants in children - correct answer ✔✔fluoxetine, escitalopram
Natural products: ADR of St John's Wort - correct answer ✔✔GI, Sexual dysfunction, HA, anxiety, fatigue,
heart complications w/ anaesthesia
Natural products: DDI of St John's Wort - correct answer ✔✔Induces multiple CYP450s and Pgp
Natural products: ADR of SAMe - correct answer ✔✔GI, flatulence, HA, insomnia, anxiety
Natural products: MOA of L-methylfolate - correct answer ✔✔Cofactor in monoamine synthesis
Natural products: MOA of St John's Wort - correct answer ✔✔MAO inhibition (weak), Monoamine
transporter inhibition
Natural products: MOA of SAMe - correct answer ✔✔Methyl donor in DA and 5HT synthesis
Landmark Trial: STAR*D Citalopram - correct answer ✔✔Remission rate 27.5%, Average 6-7 weeks, 40%
required 8-12 weeks to achieve remission
Landmark Trial: STAR*D Bupropion, sertraline, or venlafaxine after SSRI failure - correct answer
✔✔Remission rates similar between arms (18 to 25%), no difference in tolerability or time to response
Landmark Trial: STAR*D augmentation bupropion or buspirone - correct answer ✔✔Similar remission
rates (~30%), difference in tolerability
Landmark Trial: STAR*D lithium and T3 comparison - correct answer ✔✔Similar remission rates (16 to
25%), difference in tolerability
ADRs of ketamine - correct answer ✔✔ADRs include GI, Sedation, BP increase, Dissociation, Urinary
frequency/incontinence, Cognitive/motor impairment
ADRs of trazodone - correct answer ✔✔ADRs include GI, Sedation, Dry mouth, Orthostatic hypotension,
Headache, Priapism
ADRs of mirtazapine - correct answer ✔✔ADRs include Sedation, Dry mouth, Appetite increase,
Increased TGs
ADRs of bupropion - correct answer ✔✔ADRs include GI, Dry mouth, Headache, Insomnia, Anxiety,
Hypertension, Tachyarrhythmias
MOA of vortioxetine - correct answer ✔✔5HT reuptake inhibition, 5HT3 antagonism, 5HT1A agonism,
5HT1B partial agonism
MOA of trazodone - correct answer ✔✔5HT and NE reuptake inhibition (weak), Alpha-1 blocker (weak),
5HT2A antagonism, Histamine 1 antagonism
MOA of vilazodone - correct answer ✔✔5HT reuptake inhibition, 5HT1A partial agonist
MOA of mirtazapine - correct answer ✔✔Alpha 2 agonism, 5HT2 and 5HT3 antagonist, Histamine 1
antagonist
ADR of antidepressants in children - correct answer ✔✔Anxiety, irritability, akathisia, behavior changes,
SI
Preferred antidepressants to AVOID in pregnancy - correct answer ✔✔paroxetine, venlafaxine, doxepin
, Preferred antidepressants in lactation - correct answer ✔✔paroxetine, sertraline
Preferred antidepressants in children - correct answer ✔✔fluoxetine, escitalopram
Natural products: ADR of St John's Wort - correct answer ✔✔GI, Sexual dysfunction, HA, anxiety, fatigue,
heart complications w/ anaesthesia
Natural products: DDI of St John's Wort - correct answer ✔✔Induces multiple CYP450s and Pgp
Natural products: ADR of SAMe - correct answer ✔✔GI, flatulence, HA, insomnia, anxiety
Natural products: MOA of L-methylfolate - correct answer ✔✔Cofactor in monoamine synthesis
Natural products: MOA of St John's Wort - correct answer ✔✔MAO inhibition (weak), Monoamine
transporter inhibition
Natural products: MOA of SAMe - correct answer ✔✔Methyl donor in DA and 5HT synthesis
Landmark Trial: STAR*D Citalopram - correct answer ✔✔Remission rate 27.5%, Average 6-7 weeks, 40%
required 8-12 weeks to achieve remission
Landmark Trial: STAR*D Bupropion, sertraline, or venlafaxine after SSRI failure - correct answer
✔✔Remission rates similar between arms (18 to 25%), no difference in tolerability or time to response
Landmark Trial: STAR*D augmentation bupropion or buspirone - correct answer ✔✔Similar remission
rates (~30%), difference in tolerability
Landmark Trial: STAR*D lithium and T3 comparison - correct answer ✔✔Similar remission rates (16 to
25%), difference in tolerability
