ONS Chemotherapy Immunotherapy Certificate Exam Questions With Verified Answers

ONS Chemotherapy Immunotherapy Certificate Exam Questions With Verified Answers Define neoadjuvant therapy - answerTreatment is given prior to surgery to shrink the tumor Define adjuvant therapy - answerAdditional cancer treatment given after the primary treatment to lower the risk that the cancer reoccur 3 subcategories of alkylating agents: - answer1. Nitrogen mustards 2. Platinum-based agents (do not possess an alkyl group but still termed alkylating agents as they work similarly) 3. Nitrosoureas Common alkylating agents: - answerCyclophosphamide (Cytoxan) Ifosfamide (Ifex) Bendamustine (Treanda) Common platinum-based agents: - answerCisplatin (Platinol) Carboplatin (Paraplatin) What is unique about nitrosoureas agents? - answerAble to cross the blood-brain barrier; can be effective in treating some brain tumors Common nitrosoureas agents: - answerCarmustine (BiCNU) Lomustine (CeeNu) Streptozocin (Zanosar) Hypersensitivity can occur with late doses of: - answerCarboplatin These agents are typically categorized as highly emetogenic: - answer1. Alkylating agents 2. Nitrosoureas ©BRAINBARTER 2024/2025 Pre-administration labs for alkylating agents and nitrosoureas: - answerBUN Creatinine CBC w/ diff What is the medication Mesna used for? - answerBladder protectant with administration of cyclophosphamide or ifosfamide Instruct pts receiving ________ to avoid exposure to cold air and consuming cold fluids for 3-4 days following treatment - answerOxaliplatin How do antimetabolites function? - answerBy blocking DNA and RNA growth by interfering with enzymes needed for normal cell metabolism Antimetabolites work in the ___ phase. - answerS Common side effects of antimetabolites: - answerMyelosuppression GI toxicities Photosensitivity Hand-foot syndrome Common antimetabolite drugs: - answerAzacitidine Capecitabine 5-FU Cytarabine Decitabine Methotrexate The institute for Safe Medication Practices recommends what route of administration for vincristine? - answerIV piggyback via gravity Anthracycline antitumor abx work by: - answerInterfering with enzymes necessary for DNA to replicate in ALL phases of the cell cycle The two major classifications of antitumor antibiotics are: - answerAnthracyclines Non-anthracyclines Common anthracycline antitumor abx: - answerDaunorubicin Doxorubicin ©BRAINBARTER 2024/2025 Epirubicin Idarubicin The antitumor abx ___________ is not an anthracycline, but has anthracycline-type properties. - answerMitoxantrone Common non-anthracycline antitumor abx: - answerActinomycin D Mitomycin C Bleomycin Monitoring necessary with doxorubicin: - answerVesicant -- extravasation Cardiac function Lifetime dose tracking (cardiotoxicity) Lifetime dose of doxorubicin should not exceed: - answer550 mg/m^2 What cardiac protectant medication can be administered prior to doxorubicin? - answerDexrazoxane Significant side effects of doxorubicin are: - answerCardiotoxicity N/V Mucositis Diarrhea Severe myelosuppression Hepatic impairment Secondary cancers Monitoring necessary with bleomycin: - answerPulmonary toxicity Hypersensitivity reactions (esp. in lymphoma patients) Cutaneous reactions Lifetime dose tracking (pulmonary toxicity) Pulmonary fibrosis is possible when the lifetime dose of bleomycin exceeds: - answer400 units What 6 patient characteristics make CINV more likely? - answer1. Younger than 50 years 2. Hx of low alcohol intake