Stahl's Essential Psychopharmacology Neuroscientific Basis
and Practical Applications 2024 5th Edition Test Bank
Patrick is a 22-year-old male who recently experienced a psychotic-like episode after
trying MDMA ("ecstasy") while at a party. A key binding site for hallucinogens is the:
A. GABA-A receptor
B. Cannabinoid 1 receptor
C. Serotonin 2A receptor
D. Serotonin 2C receptor - C. Serotonin 2A receptor
29-year-old patient is morbidly obese and reports that he is "addicted to food". Hunger
circuitry is connected to reward circuitry via dopaminergic projections from the
hypothalamus to the nucleus accumbens.
A. True
B. False - A. True
Examples of neurotransmitters produced specifically as retrograde neurotransmitters
(i.e., those that communicate from postsynaptic neuron to presynaptic neuron) include:
A. GABA
B. Galanin
C. Histamine
D. Nitric oxide - D. Nitric oxide
An example of volume neurotransmission is:
A. Dopamine in the prefrontal cortex
B. Dopamine in the striatum
C. Norepinephrine in the prefrontal cortex
D. Norepinephrine in the striatum - A. Dopamine in the prefrontal cortex
In a G protein-linked signal transduction cascade, the second messenger can be
synthesized:
A. Intracellularly
B. Extracellularly
C. Either intra- or extracellularly - A. Intracellularly
Transport of monoamines requires energy, which is supplied by a:
A. Calcium pump
B. Potassium pump
C. Sodium pump - C. Sodium Pump
Which of the following is considered the pleasure center of the brain?
A. Cortico-striatal-thalamic-cortical loop
B. Mesolimbic dopamine pathway
,C. Mesocortical dopamine pathway
D. None of the above - B. Mesolimbic dopamine pathway
The reactive reward system signals the immediate prospect of pleasure or pain and
triggers drug-seeking behavior.
A. True
B. False - A. True
What role does the amygdala play in substance abuse?
A. Releases phasic bursts of dopamine to the nucleus accumbens when drugs of abuse
are present
B. Communicates to the ventral tegmental area when cues related to drugs of abuse
are present
C. Site of binding for most drugs of abuse
D. A and B E. A, B, and C - B. Communicates to the ventral tegmental area when cues
related to drugs of abuse are present
A 45-year-old patient has tried unsuccessfully to quit smoking several times over the
past ten years. Nicotine's actions at which receptors are considered primarily
responsible for its reinforcing effects?
A. Alpha 4 beta 2 postsynaptic receptors in the ventral tegmental area B. Alpha 7
postsynaptic receptors in the prefrontal cortex
C. A and B
D. Neither A nor B - A. Alpha 4 beta 2 postsynaptic receptors in the ventral tegmental
area
A 35-year-old cigarette smoker would like to quit but is nervous because she typically
craves a cigarette approximately every 2 hrs. The craving and withdrawal are due to:
A. Desensitization of nicotinic receptors
B. Resensitization of nicotinic receptors C. Desensitization of muscarinic receptors
D. Resensitization of muscarinic receptors - B. Resensitization of nicotinic receptors
A 44-year-old patient has schizophrenia and comorbid alcohol abuse disorder. Alcohol
has what effect on GABA and glutamate in the ventral tegmental area?
A. Increases GABA and decreases glutamate
B. Increases both GABA and glutamate C. Decreases GABA and increases glutamate
D. Decreases both GABA and glutamate - A. Increases GABA and decreases glutamate
A 26-year-old patient with ADHD has recently entered a drug rehabilitation center
following arrest for possession of cocaine. The cocaine use in this patient may be an
attempt at self-medication for ADHD symptoms because it inhibits the dopamine
transporter (but is not itself taken up into the neuron by the transporter). Thus, cocaine
has the same action at the dopamine transporter as:
A. Cocaine has the same actions at the dopamine transporter as amphetamine B.
Cocaine has the same actions at the dopamine transporter as methylphenidate
C. A and B
, D. Neither A nor B - B. Cocaine has the same actions at the dopamine transporter as
methylphenidate
What is constitutive activity?
A. Signal transduction when an agonist is bound to the receptor
B. Signal transduction when an antagonist to the receptor
C. Signal transduction when an inverse agonist is bound to the receptor
D. Signal transduction when no agonist or inverse agonist is bound to the recep - D.
Signal transduction when no agonist or inverse agonist is bound to the receptor
A partial agonist has what effect on neurotransmission?
A. Net agonism when neurotransmission is deficient
B. Net antagonism when neurotransmission is excessive
C. A and B
D. Neither A nor B - C. A and B
Receptor with four transmembrane regions changes conformation as GABA binds.
Which system is this process describing?
A. Presynaptic transporter
B. Ligand-gated ion channel
C. Voltage-sensitive ion channel - B. Ligand-gated ion channel
The known receptor sites for ligand-gated ion channels are:
A. Inside the channel
B. Outside the channel
C. Both inside and outside the channel D. Ligand-gated ion channels do not have
receptor sites - C. Both inside and outside the channel
Receptor will stop responding to an agonist:
A. When the agonist stops binding to it B. When the receptor becomes desensitized
C. When the receptor becomes inactivated
D. A and C
E. A, B, and C - E. A, B, and C
Which of the following is true?
A. Positive allosteric modulation is possible only in the presence of a neurotransmitter,
while negative allosteric modulation is possible only in the absence of a
neurotransmitter
B. Negative allosteric modulation is possible only in the presence of a neurotransmitter,
while positive allosteric modulation is possible only in the absence of a neurotransmitter
C. Both positive and negative allosteric modulations are possible only in the absence of
a neurotransmitter
D. Both positive and negative allosteric modulations are possible only in the presence of
a neurotransmitter - D. Both positive and negative allosteric modulations are possible
only in the presence of a neurotransmitter
and Practical Applications 2024 5th Edition Test Bank
Patrick is a 22-year-old male who recently experienced a psychotic-like episode after
trying MDMA ("ecstasy") while at a party. A key binding site for hallucinogens is the:
A. GABA-A receptor
B. Cannabinoid 1 receptor
C. Serotonin 2A receptor
D. Serotonin 2C receptor - C. Serotonin 2A receptor
29-year-old patient is morbidly obese and reports that he is "addicted to food". Hunger
circuitry is connected to reward circuitry via dopaminergic projections from the
hypothalamus to the nucleus accumbens.
A. True
B. False - A. True
Examples of neurotransmitters produced specifically as retrograde neurotransmitters
(i.e., those that communicate from postsynaptic neuron to presynaptic neuron) include:
A. GABA
B. Galanin
C. Histamine
D. Nitric oxide - D. Nitric oxide
An example of volume neurotransmission is:
A. Dopamine in the prefrontal cortex
B. Dopamine in the striatum
C. Norepinephrine in the prefrontal cortex
D. Norepinephrine in the striatum - A. Dopamine in the prefrontal cortex
In a G protein-linked signal transduction cascade, the second messenger can be
synthesized:
A. Intracellularly
B. Extracellularly
C. Either intra- or extracellularly - A. Intracellularly
Transport of monoamines requires energy, which is supplied by a:
A. Calcium pump
B. Potassium pump
C. Sodium pump - C. Sodium Pump
Which of the following is considered the pleasure center of the brain?
A. Cortico-striatal-thalamic-cortical loop
B. Mesolimbic dopamine pathway
,C. Mesocortical dopamine pathway
D. None of the above - B. Mesolimbic dopamine pathway
The reactive reward system signals the immediate prospect of pleasure or pain and
triggers drug-seeking behavior.
A. True
B. False - A. True
What role does the amygdala play in substance abuse?
A. Releases phasic bursts of dopamine to the nucleus accumbens when drugs of abuse
are present
B. Communicates to the ventral tegmental area when cues related to drugs of abuse
are present
C. Site of binding for most drugs of abuse
D. A and B E. A, B, and C - B. Communicates to the ventral tegmental area when cues
related to drugs of abuse are present
A 45-year-old patient has tried unsuccessfully to quit smoking several times over the
past ten years. Nicotine's actions at which receptors are considered primarily
responsible for its reinforcing effects?
A. Alpha 4 beta 2 postsynaptic receptors in the ventral tegmental area B. Alpha 7
postsynaptic receptors in the prefrontal cortex
C. A and B
D. Neither A nor B - A. Alpha 4 beta 2 postsynaptic receptors in the ventral tegmental
area
A 35-year-old cigarette smoker would like to quit but is nervous because she typically
craves a cigarette approximately every 2 hrs. The craving and withdrawal are due to:
A. Desensitization of nicotinic receptors
B. Resensitization of nicotinic receptors C. Desensitization of muscarinic receptors
D. Resensitization of muscarinic receptors - B. Resensitization of nicotinic receptors
A 44-year-old patient has schizophrenia and comorbid alcohol abuse disorder. Alcohol
has what effect on GABA and glutamate in the ventral tegmental area?
A. Increases GABA and decreases glutamate
B. Increases both GABA and glutamate C. Decreases GABA and increases glutamate
D. Decreases both GABA and glutamate - A. Increases GABA and decreases glutamate
A 26-year-old patient with ADHD has recently entered a drug rehabilitation center
following arrest for possession of cocaine. The cocaine use in this patient may be an
attempt at self-medication for ADHD symptoms because it inhibits the dopamine
transporter (but is not itself taken up into the neuron by the transporter). Thus, cocaine
has the same action at the dopamine transporter as:
A. Cocaine has the same actions at the dopamine transporter as amphetamine B.
Cocaine has the same actions at the dopamine transporter as methylphenidate
C. A and B
, D. Neither A nor B - B. Cocaine has the same actions at the dopamine transporter as
methylphenidate
What is constitutive activity?
A. Signal transduction when an agonist is bound to the receptor
B. Signal transduction when an antagonist to the receptor
C. Signal transduction when an inverse agonist is bound to the receptor
D. Signal transduction when no agonist or inverse agonist is bound to the recep - D.
Signal transduction when no agonist or inverse agonist is bound to the receptor
A partial agonist has what effect on neurotransmission?
A. Net agonism when neurotransmission is deficient
B. Net antagonism when neurotransmission is excessive
C. A and B
D. Neither A nor B - C. A and B
Receptor with four transmembrane regions changes conformation as GABA binds.
Which system is this process describing?
A. Presynaptic transporter
B. Ligand-gated ion channel
C. Voltage-sensitive ion channel - B. Ligand-gated ion channel
The known receptor sites for ligand-gated ion channels are:
A. Inside the channel
B. Outside the channel
C. Both inside and outside the channel D. Ligand-gated ion channels do not have
receptor sites - C. Both inside and outside the channel
Receptor will stop responding to an agonist:
A. When the agonist stops binding to it B. When the receptor becomes desensitized
C. When the receptor becomes inactivated
D. A and C
E. A, B, and C - E. A, B, and C
Which of the following is true?
A. Positive allosteric modulation is possible only in the presence of a neurotransmitter,
while negative allosteric modulation is possible only in the absence of a
neurotransmitter
B. Negative allosteric modulation is possible only in the presence of a neurotransmitter,
while positive allosteric modulation is possible only in the absence of a neurotransmitter
C. Both positive and negative allosteric modulations are possible only in the absence of
a neurotransmitter
D. Both positive and negative allosteric modulations are possible only in the presence of
a neurotransmitter - D. Both positive and negative allosteric modulations are possible
only in the presence of a neurotransmitter
