Test RBank Rfor RHUETHER Rand RMCCANCES
RUnderstanding RPathophysiology, RCanadian REdition R2nd
REdition Rby RKelly RPower-Kean,Stephanie RZettel,
RMohamed RTOUFIC REl-Hussein, RSue RE.HUETHER,
RKathryn RL. RMCCANCE R| R9780323778848 R| R2024
RChapter R1-42
Chapter R01: RCellular RBiology RHuether R& RMcCance: RUnderstanding
RPathophysiology, R6th REdition
MULTIPLE RCHOICE
1. A Rstudent Ris Robserving Ra Rcell Runder Rthe Rmicroscope. RIt Ris Robserved Rto
Rhave Rsupercoiled RDNA Rwith Rhistones. RWhich Rof Rthe Rfollowing Rwould Ralso
Rbe Robserved Rby Rthe Rstudent? Ra. RA Rsingle Rcircular Rchromosome
b. A Rnucleus
c. Free-floating Rnuclear Rmaterial
d. No Rorganelles
ANS: RB
The Rcell Rdescribed Ris Ra Reukaryotic Rcell, Rso Rit Rhas Rhistones Rand Ra
Rsupercoiled RDNA Rwithin Rits Rnucleus; Rthus, Rthe Rnucleus Rshould Rbe Robserved.
RA Rsingle Rcircular Rchromosome Rcalled Ra Rprokaryote Rcontains Rfree-floating
Rnuclear Rmaterial Rbut Rhas Rno Rorganelles.
REF: Rp. R2
2. A Rnurse Ris Rinstructing Rthe Rstaff Rabout Rcellular Rfunctions. RWhich Rcellular
Rfunction Ris Rthe Rnurse Rdescribing Rwhen Ran Risolated Rcell Rabsorbs Roxygen Rand
Ruses Rit Rto Rtransform Rnutrients Rto Renergy? Ra.
Metabolic Rabsorption
b. Communication
c. Secretion
d. Respiration
ANS: RD
The Rcell’s Rability Rto Rabsorb Roxygen Ris Rreferred Rto Ras Rrespiration Rwhile Rits
Rcommunication Rability Rinvolves Rmaintenance Rof Ra Rsteady Rdynamic Rstate,
Rmetabolic Rabsorption Rprovides Rnutrition, Rand Rsecretion Rallows Rfor Rthe
Rsynthesizing Rof Rnew Rsubstances.
REF: Rp. R2
,3. A Reukaryotic Rcell Ris Rundergoing RDNA Rreplication. RIn Rwhich Rregion Rof Rthe
Rcell Rwould Rmost Rof Rthe Rgenetic Rinformation Rbe Rcontained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. Nucleus RCytoplasm
, ANS: RC
The Rregion Rof Rthe Rcell Rthat Rcontains Rgenetic Rmaterial, Rincluding Ra Rlarge
Ramount Rof Rribonucleic Racid, Rmost Rof Rthe RDNA, Rand RDNA-binding Rproteins,
Ris Rthe Rnucleolus, Rwhich Ris Rlocated Rwithin Rthe Rcell’s Rnucleus. RMitochondria
Ris Rassociated Rwith Rcellular Rrespiration, Rwhile Rribosomes Rare Rinvolved Rwith
Rprotein Rmanufacturing. RCytoplasm Ris Ra Rfluid Rfilling Rthat Ris Ra Rcomponent Rof
Rthe Rcell.
REF: Rp. R2
4. Which Rof Rthe Rfollowing Rcan Rremove Rproteins Rattached Rto Rthe Rcell’s Rbilayer Rby
Rdissolving Rthe Rlayer Ritself?
a. Peripheral Rmembrane Rproteins
b. Integral Rmembrane Rproteins
c. Glycoproteins
d. Cell Radhesion Rmolecules
ANS: RB
Proteins Rdirectly Rattached Rto Rthe Rmembrane Rbilayer Rcan Rbe Rremoved Rby Rthe
Raction Rof Rintegral Rmembrane Rproteins Rthat Rdissolve Rthe Rbilayer. RPeripheral
Rmembrane Rproteins Rreside Rat Rthe Rsurface Rwhile Rcell Radhesion Rmolecules Rare
Ron Rthe Routside Rof Rthe Rmembrane. RGlycoprotein Rmarks Rcells Rand Rdoes Rnot
Rfloat.
REF: Rp. R7
5. Which Rof Rthe Rfollowing Rcan Rbind Rto Rplasma Rmembrane Rreceptors?
a. Oxygen
b. Ribosomes
c. Amphipathic Rlipids
d. Ligands
ANS: RD
Ligands Rare Rthe Ronly Rspecific Rmolecules Rthat Rcan Rbind Rwith Rreceptors Ron Rthe
Rcell Rmembrane.
REF: Rp. R9
6. A Rnurse Ris Rreviewing Ra Rreport Rfrom Ra Rpatient Rwith Rmetastatic Rcancer.
RWhat Ralternation Rin Rthe Rextracellular Rmatrix Rwould Rsupport Rthe Rdiagnosis
Rof Rmetastatic Rcancer?a.
Decreased Rfibronectin
b. Increased Rcollagen
c. Decreased Relastin
d. Increased Rglycoproteins
, ANS: RA
Only Ra Rreduced Ramount Rof Rfibronectin Ris Rfound Rin Rsome Rtypes Rof Rcancerous
Rcells, Rallowing Rthem Rto Rtravel Ror Rmetastasize.
REF: Rp. R10
7. Which Rform Rof Rcell Rcommunication Ris Rused Rto Rrelate Rto Rother Rcells Rin Rdirect
Rphysical Rcontact? Ra.
Cell Rjunction
b. Gap Rjunction
c. Desmosome
d. Tight Rjunction
ANS: RA
Cell Rjunctions Rhold Rcells Rtogether Rand Rpermit Rmolecules Rto Rpass Rfrom Rcell Rto
Rcell.
Gap Rjunctions Rallow Rfor Rcellular Rcommunication Rbetween Rcells. RNeither
Rdesmosomes Rnor Rtight Rjunctions Rare Rassociated Rwith Rcellular Rcommunication.
REF: Rp. R11
8. Pancreatic Rbeta Rcells Rsecrete Rinsulin, Rwhich Rinhibits Rsecretion Rof Rglucagon Rfrom
Rneighboring Ralpha Rcells. RThis Raction Ris Ran Rexample Rof Rwhich Rof Rthe
Rfollowing Rsignaling Rtypes? Ra. RParacrine
b. Autocrine
c. Neurohormonal
d. Hormonal
ANS: RA
Paracrine Rsignaling Rinvolves Rthe Rrelease Rof Rlocal Rchemical Rmediators Rthat Rare
Rquickly Rtaken Rup, Rdestroyed, Ror Rimmobilized, Ras Rin Rthe Rcase Rof Rinsulin
Rand Rthe Rinhibition Rof Rthe Rsecretion Rof Rglucagon. RNone Rof Rthe Rother
Roptions Rinvolve Rsignaling Rthat Ris Rassociated Rwith Ra Rlocal Rchemical Rmediator
Rlike Rinsulin.
REF: Rp. R12
9. In Rcellular Rmetabolism, Reach Renzyme Rhas Ra Rhigh Raffinity Rfor Ra:
a. solute.
b. substrate.
ANS:
RB
RUnderstanding RPathophysiology, RCanadian REdition R2nd
REdition Rby RKelly RPower-Kean,Stephanie RZettel,
RMohamed RTOUFIC REl-Hussein, RSue RE.HUETHER,
RKathryn RL. RMCCANCE R| R9780323778848 R| R2024
RChapter R1-42
Chapter R01: RCellular RBiology RHuether R& RMcCance: RUnderstanding
RPathophysiology, R6th REdition
MULTIPLE RCHOICE
1. A Rstudent Ris Robserving Ra Rcell Runder Rthe Rmicroscope. RIt Ris Robserved Rto
Rhave Rsupercoiled RDNA Rwith Rhistones. RWhich Rof Rthe Rfollowing Rwould Ralso
Rbe Robserved Rby Rthe Rstudent? Ra. RA Rsingle Rcircular Rchromosome
b. A Rnucleus
c. Free-floating Rnuclear Rmaterial
d. No Rorganelles
ANS: RB
The Rcell Rdescribed Ris Ra Reukaryotic Rcell, Rso Rit Rhas Rhistones Rand Ra
Rsupercoiled RDNA Rwithin Rits Rnucleus; Rthus, Rthe Rnucleus Rshould Rbe Robserved.
RA Rsingle Rcircular Rchromosome Rcalled Ra Rprokaryote Rcontains Rfree-floating
Rnuclear Rmaterial Rbut Rhas Rno Rorganelles.
REF: Rp. R2
2. A Rnurse Ris Rinstructing Rthe Rstaff Rabout Rcellular Rfunctions. RWhich Rcellular
Rfunction Ris Rthe Rnurse Rdescribing Rwhen Ran Risolated Rcell Rabsorbs Roxygen Rand
Ruses Rit Rto Rtransform Rnutrients Rto Renergy? Ra.
Metabolic Rabsorption
b. Communication
c. Secretion
d. Respiration
ANS: RD
The Rcell’s Rability Rto Rabsorb Roxygen Ris Rreferred Rto Ras Rrespiration Rwhile Rits
Rcommunication Rability Rinvolves Rmaintenance Rof Ra Rsteady Rdynamic Rstate,
Rmetabolic Rabsorption Rprovides Rnutrition, Rand Rsecretion Rallows Rfor Rthe
Rsynthesizing Rof Rnew Rsubstances.
REF: Rp. R2
,3. A Reukaryotic Rcell Ris Rundergoing RDNA Rreplication. RIn Rwhich Rregion Rof Rthe
Rcell Rwould Rmost Rof Rthe Rgenetic Rinformation Rbe Rcontained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. Nucleus RCytoplasm
, ANS: RC
The Rregion Rof Rthe Rcell Rthat Rcontains Rgenetic Rmaterial, Rincluding Ra Rlarge
Ramount Rof Rribonucleic Racid, Rmost Rof Rthe RDNA, Rand RDNA-binding Rproteins,
Ris Rthe Rnucleolus, Rwhich Ris Rlocated Rwithin Rthe Rcell’s Rnucleus. RMitochondria
Ris Rassociated Rwith Rcellular Rrespiration, Rwhile Rribosomes Rare Rinvolved Rwith
Rprotein Rmanufacturing. RCytoplasm Ris Ra Rfluid Rfilling Rthat Ris Ra Rcomponent Rof
Rthe Rcell.
REF: Rp. R2
4. Which Rof Rthe Rfollowing Rcan Rremove Rproteins Rattached Rto Rthe Rcell’s Rbilayer Rby
Rdissolving Rthe Rlayer Ritself?
a. Peripheral Rmembrane Rproteins
b. Integral Rmembrane Rproteins
c. Glycoproteins
d. Cell Radhesion Rmolecules
ANS: RB
Proteins Rdirectly Rattached Rto Rthe Rmembrane Rbilayer Rcan Rbe Rremoved Rby Rthe
Raction Rof Rintegral Rmembrane Rproteins Rthat Rdissolve Rthe Rbilayer. RPeripheral
Rmembrane Rproteins Rreside Rat Rthe Rsurface Rwhile Rcell Radhesion Rmolecules Rare
Ron Rthe Routside Rof Rthe Rmembrane. RGlycoprotein Rmarks Rcells Rand Rdoes Rnot
Rfloat.
REF: Rp. R7
5. Which Rof Rthe Rfollowing Rcan Rbind Rto Rplasma Rmembrane Rreceptors?
a. Oxygen
b. Ribosomes
c. Amphipathic Rlipids
d. Ligands
ANS: RD
Ligands Rare Rthe Ronly Rspecific Rmolecules Rthat Rcan Rbind Rwith Rreceptors Ron Rthe
Rcell Rmembrane.
REF: Rp. R9
6. A Rnurse Ris Rreviewing Ra Rreport Rfrom Ra Rpatient Rwith Rmetastatic Rcancer.
RWhat Ralternation Rin Rthe Rextracellular Rmatrix Rwould Rsupport Rthe Rdiagnosis
Rof Rmetastatic Rcancer?a.
Decreased Rfibronectin
b. Increased Rcollagen
c. Decreased Relastin
d. Increased Rglycoproteins
, ANS: RA
Only Ra Rreduced Ramount Rof Rfibronectin Ris Rfound Rin Rsome Rtypes Rof Rcancerous
Rcells, Rallowing Rthem Rto Rtravel Ror Rmetastasize.
REF: Rp. R10
7. Which Rform Rof Rcell Rcommunication Ris Rused Rto Rrelate Rto Rother Rcells Rin Rdirect
Rphysical Rcontact? Ra.
Cell Rjunction
b. Gap Rjunction
c. Desmosome
d. Tight Rjunction
ANS: RA
Cell Rjunctions Rhold Rcells Rtogether Rand Rpermit Rmolecules Rto Rpass Rfrom Rcell Rto
Rcell.
Gap Rjunctions Rallow Rfor Rcellular Rcommunication Rbetween Rcells. RNeither
Rdesmosomes Rnor Rtight Rjunctions Rare Rassociated Rwith Rcellular Rcommunication.
REF: Rp. R11
8. Pancreatic Rbeta Rcells Rsecrete Rinsulin, Rwhich Rinhibits Rsecretion Rof Rglucagon Rfrom
Rneighboring Ralpha Rcells. RThis Raction Ris Ran Rexample Rof Rwhich Rof Rthe
Rfollowing Rsignaling Rtypes? Ra. RParacrine
b. Autocrine
c. Neurohormonal
d. Hormonal
ANS: RA
Paracrine Rsignaling Rinvolves Rthe Rrelease Rof Rlocal Rchemical Rmediators Rthat Rare
Rquickly Rtaken Rup, Rdestroyed, Ror Rimmobilized, Ras Rin Rthe Rcase Rof Rinsulin
Rand Rthe Rinhibition Rof Rthe Rsecretion Rof Rglucagon. RNone Rof Rthe Rother
Roptions Rinvolve Rsignaling Rthat Ris Rassociated Rwith Ra Rlocal Rchemical Rmediator
Rlike Rinsulin.
REF: Rp. R12
9. In Rcellular Rmetabolism, Reach Renzyme Rhas Ra Rhigh Raffinity Rfor Ra:
a. solute.
b. substrate.
ANS:
RB
