NUR3196 Exam 4 Drugs With Complete Solutions
Ibuprofen (Advil, Motrin) Therapeutic class Answer analgesic, anti-inflammatory drug,
antipyretic
Ibuprofen (Advil, Motrin) Pharmacologic class Answer NSAID
Ibuprofen (Advil, Motrin) Actions and Uses Answer inhibits prostaglandin synthesis; can
be used for pain associated w/ musculoskeletal disorders, headache, dental pain, and
dysmenorrhea
Ibuprofen (Advil, Motrin) Administration give on empty stomach give with food if nausea,
vomiting or GI pain occurs, pts w/ asthma or aspirin allergy more likely to have
hypersensitive reaction
Ibuprofen (Advil, Motrin) Pregnancy category Answer C, D after 30 weeks
Ibuprofen (Advil, Motrin) Onset Answer 30-60 min
Ibuprofen (Advil, Motrin) Duration Answer 4-6 h
Ibuprofen (Advil, Motrin) Adverse Effects - Answer - nausea, heart burn, epigastric pain,
dizziness, peripheral edema, aplastic anemia, leukopenia, anaphylaxis, GI ulcers/CKD in
long term use
Ibuprofen (Advil, Motrin) Contraindications - Answer active peptic ulcers, CKD, hepatic
impairment, nasal polyps, angioedema, bronchospasms due to NSAIDs; use caution w/
HF, serious HTN, hx of stroke/MI
,Ibuprofen (Advil, Motrin) Black box- increased risk of serious thrombotic events, MI,
stroke; may increase w/ duration of use
Ibuprofen (Advil, Motrin) Drug to drug interactions- avoid anticoagulants/coag modifiers
related to ibuprofen impaction platelet function, aspirin use can decrease action, effects
of antihypertensives (diuretics, beta blockers, ACE inhibitors) decreased w/ ibuprofen,
diuretics, use w/ NSAIDs/ alcohol/corticosteroids can cause serious GI events
Ibuprofen (Advil, Motrin) Lab test interactions Answer increase bleeding time/AST/ALT,
decrease hemoglobin/hematocrit
Ibuprofen (Advil, Motrin) Treatment of overdose Answer alkaline drug can increase
urinary excretion
Prednisone Therapeutic class Answer anti-inflammatory drug
Prednisone Pharmacologic class Answer corticosteroid
Prednisone Actions and Uses Answer -A synthetic corticosteroid
-Actions are the result of being metabolized to an active form, which is also available as
drug called prednisolone
-When used for inflammation, duration of therapy is limited 4-10 days
-For long-term therapy, alternate-day dosing is used
-Occasionally used to terminate acute bronchospasm in patients with asthma
-Used as antineoplastic agent for patients with certain cancers (Hodgkin's disease,
acute leukemia, lymphomas)
corticosteroids - Answer - Effective in treating severe inflammation
- naturally released from adrenal cortex
- Suppress histamine and prostaglandins
,- Can inhibit immune system to reduce inflammation
Prednisone Administration- give IM injections deep to avoid atrophy or abscesses, do
not use if pt has signs of systemic infection, when used for > 10 days, dose must be
slowly tapered
Tablet and oral solution forms
Prednisone Pregnancy category- C
Prednisone Onset-1-2 h
Prednisone Duration - 24-36 h
Prednisone Side Effects - Answer long term use can cause cushing's syndrome
(hyperglycemia, fat redistribution, muscle weakness, bruising, bones that fracture
easily) and peptic ulcers
Prednisone Contraindications - Answer use w/ caution for peptic ulcers, ulerative colitis,
diverticulitis; do not use w/ active viral/bacterial/protozoan infection
Prednisone Drug to drug interactions - Answer azole antifungals increases effects,
increases effects of statins, increases hyperglycemia so insulin/oral hypoglycemic
drugs may need to be adjusted, decreases the effectiveness of vaccines
Prednisone Lab test interactions - Answer may inhibit antibody response to toxoids and
vaccines, may increase blood glucose, may decrease serum
calcium/potassium/thyroxine
Acetaminophen has no anti-inflammatory action and is not an NSAID therefore it is not
effective in treating arthritis or pain caused by tissue swelling following injury
, Acetaminophen (Tylenol) Therapeutic class antipyretic, analgesic
Acetaminophen (Tylenol) Pharmacologic class Centrally acting COX inhibitor
Acetaminophen (Tylenol) Actions and Uses - Answer - acts directly at the level of the
hypothalamus and by dilating peripheral blood vessels, which enables sweating and
dissipation of heat
- treatment of children's fever; for moderate pain when aspirin is contraindicated; can
be used with opioids for severe pain
- without effect on platelet aggregation/cardiotoxicity
- no GI bleeding/ulcers
Acetaminophen, ibuprofen, and aspirin are equally effective for - Answer the relief of
pain and the reduction of fever
Acetaminophen (Tylenol) Administration - Answer - liquids of different strengths (use
correct one for children)
- do not admin to pt who drinks alcohol regularly due to hepatotoxcity
- found in many OTC medications (do not double dose)
Acetaminophen (Tylenol) Pregnancy category - Answer B
Acetaminophen (Tylenol) Onset - Answer 30-60 min
Acetaminophen (Tylenol) Peak - Answer 0.5-2 h
Acetaminophen (Tylenol) Duration - Answer 4-6 h
Acetaminophen (Tylenol) Adverse Effects - Answer - due to high doses/long term use
Ibuprofen (Advil, Motrin) Therapeutic class Answer analgesic, anti-inflammatory drug,
antipyretic
Ibuprofen (Advil, Motrin) Pharmacologic class Answer NSAID
Ibuprofen (Advil, Motrin) Actions and Uses Answer inhibits prostaglandin synthesis; can
be used for pain associated w/ musculoskeletal disorders, headache, dental pain, and
dysmenorrhea
Ibuprofen (Advil, Motrin) Administration give on empty stomach give with food if nausea,
vomiting or GI pain occurs, pts w/ asthma or aspirin allergy more likely to have
hypersensitive reaction
Ibuprofen (Advil, Motrin) Pregnancy category Answer C, D after 30 weeks
Ibuprofen (Advil, Motrin) Onset Answer 30-60 min
Ibuprofen (Advil, Motrin) Duration Answer 4-6 h
Ibuprofen (Advil, Motrin) Adverse Effects - Answer - nausea, heart burn, epigastric pain,
dizziness, peripheral edema, aplastic anemia, leukopenia, anaphylaxis, GI ulcers/CKD in
long term use
Ibuprofen (Advil, Motrin) Contraindications - Answer active peptic ulcers, CKD, hepatic
impairment, nasal polyps, angioedema, bronchospasms due to NSAIDs; use caution w/
HF, serious HTN, hx of stroke/MI
,Ibuprofen (Advil, Motrin) Black box- increased risk of serious thrombotic events, MI,
stroke; may increase w/ duration of use
Ibuprofen (Advil, Motrin) Drug to drug interactions- avoid anticoagulants/coag modifiers
related to ibuprofen impaction platelet function, aspirin use can decrease action, effects
of antihypertensives (diuretics, beta blockers, ACE inhibitors) decreased w/ ibuprofen,
diuretics, use w/ NSAIDs/ alcohol/corticosteroids can cause serious GI events
Ibuprofen (Advil, Motrin) Lab test interactions Answer increase bleeding time/AST/ALT,
decrease hemoglobin/hematocrit
Ibuprofen (Advil, Motrin) Treatment of overdose Answer alkaline drug can increase
urinary excretion
Prednisone Therapeutic class Answer anti-inflammatory drug
Prednisone Pharmacologic class Answer corticosteroid
Prednisone Actions and Uses Answer -A synthetic corticosteroid
-Actions are the result of being metabolized to an active form, which is also available as
drug called prednisolone
-When used for inflammation, duration of therapy is limited 4-10 days
-For long-term therapy, alternate-day dosing is used
-Occasionally used to terminate acute bronchospasm in patients with asthma
-Used as antineoplastic agent for patients with certain cancers (Hodgkin's disease,
acute leukemia, lymphomas)
corticosteroids - Answer - Effective in treating severe inflammation
- naturally released from adrenal cortex
- Suppress histamine and prostaglandins
,- Can inhibit immune system to reduce inflammation
Prednisone Administration- give IM injections deep to avoid atrophy or abscesses, do
not use if pt has signs of systemic infection, when used for > 10 days, dose must be
slowly tapered
Tablet and oral solution forms
Prednisone Pregnancy category- C
Prednisone Onset-1-2 h
Prednisone Duration - 24-36 h
Prednisone Side Effects - Answer long term use can cause cushing's syndrome
(hyperglycemia, fat redistribution, muscle weakness, bruising, bones that fracture
easily) and peptic ulcers
Prednisone Contraindications - Answer use w/ caution for peptic ulcers, ulerative colitis,
diverticulitis; do not use w/ active viral/bacterial/protozoan infection
Prednisone Drug to drug interactions - Answer azole antifungals increases effects,
increases effects of statins, increases hyperglycemia so insulin/oral hypoglycemic
drugs may need to be adjusted, decreases the effectiveness of vaccines
Prednisone Lab test interactions - Answer may inhibit antibody response to toxoids and
vaccines, may increase blood glucose, may decrease serum
calcium/potassium/thyroxine
Acetaminophen has no anti-inflammatory action and is not an NSAID therefore it is not
effective in treating arthritis or pain caused by tissue swelling following injury
, Acetaminophen (Tylenol) Therapeutic class antipyretic, analgesic
Acetaminophen (Tylenol) Pharmacologic class Centrally acting COX inhibitor
Acetaminophen (Tylenol) Actions and Uses - Answer - acts directly at the level of the
hypothalamus and by dilating peripheral blood vessels, which enables sweating and
dissipation of heat
- treatment of children's fever; for moderate pain when aspirin is contraindicated; can
be used with opioids for severe pain
- without effect on platelet aggregation/cardiotoxicity
- no GI bleeding/ulcers
Acetaminophen, ibuprofen, and aspirin are equally effective for - Answer the relief of
pain and the reduction of fever
Acetaminophen (Tylenol) Administration - Answer - liquids of different strengths (use
correct one for children)
- do not admin to pt who drinks alcohol regularly due to hepatotoxcity
- found in many OTC medications (do not double dose)
Acetaminophen (Tylenol) Pregnancy category - Answer B
Acetaminophen (Tylenol) Onset - Answer 30-60 min
Acetaminophen (Tylenol) Peak - Answer 0.5-2 h
Acetaminophen (Tylenol) Duration - Answer 4-6 h
Acetaminophen (Tylenol) Adverse Effects - Answer - due to high doses/long term use
