NUR3196 Exam Three Prototype Drugs Questions
And Accurate Answers
Aspirin Action
Salicylate (acetylsalicylic acid)
- inhibits prostaglandin synthesis
- anti-inflammatory, antiplatelet, antipyretic effects
- toxic serum salicylate level: greater than 300 mcg/mL
- max dose: 4g/day
Aspirin Caution
- dont take w/ other NSAIDs
- avoid last trimester of pregnancy
- don't give to children w/ flu or virus symptoms (Reye syndrome)
Aspirin side effects
- dizziness, lethargy, headache, confusion, agitation, Nausea and GI distress,
diaphoresis, dehydration
Aspirin Adverse Reactions
- tinnitus, hearing loss, hypo/hyperglycemia, reye syndrome
Aspirin Drug Interactions
- increased bleeding with anticoagulants and other NSAIDs
- hypoglycemia with oral antidiabetics
- increased gastric ulcer risk with glucocorticoids
- decreased effects of ACE inhibitors, loop diuretics
Aspirin Lab interactions
- increased PT, bleeding time, INR, uric acid
,- decreased cholesterol, T3 and T4 levels, K
Aspirin food interactions
foods with salicylates
- prunes
- raisins
- licorice
- curry
- paprika
Ibuprofen action
- propionic acid derivative
- most widely used NSAID
- highly protein bound
- inhibits COX-1 and COX-2 by blocking arachidonate binding
- used for pain, osteoarthritis, rheumatoid arthritis
Ibuprofen side/adverse effects
- drowsiness, dizziness, headache, confusion
- blurred vision, hearing loss, tinnitus, edema
- gastric distress & bleeding
- anaphylaxis
Ibuprofen drug interactions
- increased bleeding with warfarin
- increased effects with phenytoin, sulfonamides, warfarin
- decreased effect with aspirin
Celecoxib action
Nonsteroidal anti-inflammatory
, COX-2 inhibitor
Celecoxib use
- pain, osteoarthritis, rheumatoid arthritis
- painful dysmenorrhea
- migraine
celecoxib food interactions
gingko biloba may increase bleeding risk
celecoxib caution
pt's with renal and hepatic dysfunction
celecoxib side/adverse effects
-headache, dizziness, sinusitis
-N/V/D
-GI bleeding
-HTN
-Hearing loss
-Anaphylaxis
Infliximab action
immunomodulator
tumor necrosis factor blocker
infliximab uses
-psoriasis
-rheumatoid arthritis
- ulcerative colitis
-crohn's diseases
-given thru IV only
infliximab caution
pt's with hepatic dysfunction, bone marrow suppression, DM, COPD
And Accurate Answers
Aspirin Action
Salicylate (acetylsalicylic acid)
- inhibits prostaglandin synthesis
- anti-inflammatory, antiplatelet, antipyretic effects
- toxic serum salicylate level: greater than 300 mcg/mL
- max dose: 4g/day
Aspirin Caution
- dont take w/ other NSAIDs
- avoid last trimester of pregnancy
- don't give to children w/ flu or virus symptoms (Reye syndrome)
Aspirin side effects
- dizziness, lethargy, headache, confusion, agitation, Nausea and GI distress,
diaphoresis, dehydration
Aspirin Adverse Reactions
- tinnitus, hearing loss, hypo/hyperglycemia, reye syndrome
Aspirin Drug Interactions
- increased bleeding with anticoagulants and other NSAIDs
- hypoglycemia with oral antidiabetics
- increased gastric ulcer risk with glucocorticoids
- decreased effects of ACE inhibitors, loop diuretics
Aspirin Lab interactions
- increased PT, bleeding time, INR, uric acid
,- decreased cholesterol, T3 and T4 levels, K
Aspirin food interactions
foods with salicylates
- prunes
- raisins
- licorice
- curry
- paprika
Ibuprofen action
- propionic acid derivative
- most widely used NSAID
- highly protein bound
- inhibits COX-1 and COX-2 by blocking arachidonate binding
- used for pain, osteoarthritis, rheumatoid arthritis
Ibuprofen side/adverse effects
- drowsiness, dizziness, headache, confusion
- blurred vision, hearing loss, tinnitus, edema
- gastric distress & bleeding
- anaphylaxis
Ibuprofen drug interactions
- increased bleeding with warfarin
- increased effects with phenytoin, sulfonamides, warfarin
- decreased effect with aspirin
Celecoxib action
Nonsteroidal anti-inflammatory
, COX-2 inhibitor
Celecoxib use
- pain, osteoarthritis, rheumatoid arthritis
- painful dysmenorrhea
- migraine
celecoxib food interactions
gingko biloba may increase bleeding risk
celecoxib caution
pt's with renal and hepatic dysfunction
celecoxib side/adverse effects
-headache, dizziness, sinusitis
-N/V/D
-GI bleeding
-HTN
-Hearing loss
-Anaphylaxis
Infliximab action
immunomodulator
tumor necrosis factor blocker
infliximab uses
-psoriasis
-rheumatoid arthritis
- ulcerative colitis
-crohn's diseases
-given thru IV only
infliximab caution
pt's with hepatic dysfunction, bone marrow suppression, DM, COPD
