JACI PRIMER EXAM 2024-2025 ACTUAL EXAM
120 QUESTIONS AND CORRECT DETAILED
ANSWERS WITH RATIONALES (100% VERIFIED
ANSWERS) |ALREADY GRADED
Terms in this set (120)
,Question 1. A 36-year-old 1. Answer: C
woman is seen in the Explanation: MPO is a serine protease that constitutes
emergency department approximately 5% of the total protein content of a
for new-onset shortness neutrophil. The autoantibodies directed against MPO
of breath with wheezing. are more often seen in patients with Churg-Strauss
After bronchodilation syndrome. The combination of the perinuclear
therapy, the patient no antineutrophil cytoplasmic antibody pattern and MPO
longer wheezes. Other or MPO-antineutrophil cytoplasmic antibody is
than chronic sinusitis, she strongly associated with Churg- Strauss syndrome.
has been well.
Examination shows her to
be comfortable, afebrile,
and normotensive, with a
respiratory rate of 14
breaths/min. No wheezes
are auscultated. Tender
subcutaneous nodules are
discovered on her right
anterior leg. Screening
laboratory tests reveal a
mild anemia and slightly
increased white blood cell
count with increased
eosinophil numbers. ESR is
88 mm, and the hsCRP
level is 46 mg/dL. Chest
radiography shows patchy
opacities without lobar or
segmental distribution.
What laboratory test
would be highly
suggestive that this is
Churg-Strauss syndrome?
A. antinuclear antibody
(ANA)
B. anti-proteinase 3
C. anti-myeloperoxidase
,(anti-MPO)
D. anti-extractible nuclear
antigen (anti-ENA) E. anti-
double-s
Question 1. Allogeneic 1. Answer: B
hematopoietic stem cell Explanation: Parents are haploidentical with their
transplantation is often children. One fourth of siblings can be HLA
used for the treatment of genoidentical to the patient. A matched unrelated
acute leukemia. The most donor would be HLA phenoidentical. The risk of graft-
de- sirable source of versus-host disease increases with differences in
donor cells is from — minor antigens, leading to increased
A. a parent. morbidity/mortality in nonrelated recipients.
B. an HLA-matched
sibling.
C. HLA-matched umbilical
cord blood.
D. an HLA-matched
unrelated donor.
Question 1. An 18-year-old 1. Answer: B
woman presents with a Explanation: From the 4 options, option B is the most
history of recurrent likely answer. HIV infection can be considered as a
respiratory tract infections cause of immunodeficiency at any age. Options A, C,
in the past 3 months. She and D are primary immunodeficiencies that present
has been previously clinically in infancy or early childhood.
healthy. Which of the
following is the most likely
cause of
immunodeficiency in this
patient?
A. severe combined
immunodeficiency
B. HIV infection
C. X-linked
agammaglobulinemia
D. hyper-IgM syndrome
, Question 1. Choose the 1. Answer: D
alternative that best Explanation: The clinical symptoms of recurrent
describes the most sinopulmonary infections and chronic diarrhea point
appropriate initial to an antibody deficiency syndrome, which should be
laboratory test to evaluate initially screened by means of measurement of serum
a patient with re- current immunoglobulin levels. Lymphocyte
bacterial sinopulmonary immunophenotyping and mitogen proliferation assays
infections and chronic are particularly useful in the evaluation of cellular
diarrhea caused by immunodeficiencies, although B-cell
Giardia lamblia. immunophenotyping has utility as a secondary test in
A. lymphocyte evaluating humoral immunodeficiencies. DHR is used
immunophenotyping to evaluate phagocyte defects in oxidative burst,
B. mitogen-induced which are primarily seen in chronic granulomatous
lymphocyte proliferation disorder.
C. oxidative burst by
dihydrorhodamine 123
(DHR)
D. serum immunoglobulin
levels
Question 1. 1. Answer: A
Concentrations of which Explanation: This is important not only because
of the following allergens control of indoor humidity is important in reducing
are most closely related mite exposure but also because the presence of
to indoor humidity? house dust mites is less in arid climates or at higher
A. Dermatophagoides altitudes.
farinae
B. Blatella germanica
C. Alternaria alternata
D. Felis domesticus
120 QUESTIONS AND CORRECT DETAILED
ANSWERS WITH RATIONALES (100% VERIFIED
ANSWERS) |ALREADY GRADED
Terms in this set (120)
,Question 1. A 36-year-old 1. Answer: C
woman is seen in the Explanation: MPO is a serine protease that constitutes
emergency department approximately 5% of the total protein content of a
for new-onset shortness neutrophil. The autoantibodies directed against MPO
of breath with wheezing. are more often seen in patients with Churg-Strauss
After bronchodilation syndrome. The combination of the perinuclear
therapy, the patient no antineutrophil cytoplasmic antibody pattern and MPO
longer wheezes. Other or MPO-antineutrophil cytoplasmic antibody is
than chronic sinusitis, she strongly associated with Churg- Strauss syndrome.
has been well.
Examination shows her to
be comfortable, afebrile,
and normotensive, with a
respiratory rate of 14
breaths/min. No wheezes
are auscultated. Tender
subcutaneous nodules are
discovered on her right
anterior leg. Screening
laboratory tests reveal a
mild anemia and slightly
increased white blood cell
count with increased
eosinophil numbers. ESR is
88 mm, and the hsCRP
level is 46 mg/dL. Chest
radiography shows patchy
opacities without lobar or
segmental distribution.
What laboratory test
would be highly
suggestive that this is
Churg-Strauss syndrome?
A. antinuclear antibody
(ANA)
B. anti-proteinase 3
C. anti-myeloperoxidase
,(anti-MPO)
D. anti-extractible nuclear
antigen (anti-ENA) E. anti-
double-s
Question 1. Allogeneic 1. Answer: B
hematopoietic stem cell Explanation: Parents are haploidentical with their
transplantation is often children. One fourth of siblings can be HLA
used for the treatment of genoidentical to the patient. A matched unrelated
acute leukemia. The most donor would be HLA phenoidentical. The risk of graft-
de- sirable source of versus-host disease increases with differences in
donor cells is from — minor antigens, leading to increased
A. a parent. morbidity/mortality in nonrelated recipients.
B. an HLA-matched
sibling.
C. HLA-matched umbilical
cord blood.
D. an HLA-matched
unrelated donor.
Question 1. An 18-year-old 1. Answer: B
woman presents with a Explanation: From the 4 options, option B is the most
history of recurrent likely answer. HIV infection can be considered as a
respiratory tract infections cause of immunodeficiency at any age. Options A, C,
in the past 3 months. She and D are primary immunodeficiencies that present
has been previously clinically in infancy or early childhood.
healthy. Which of the
following is the most likely
cause of
immunodeficiency in this
patient?
A. severe combined
immunodeficiency
B. HIV infection
C. X-linked
agammaglobulinemia
D. hyper-IgM syndrome
, Question 1. Choose the 1. Answer: D
alternative that best Explanation: The clinical symptoms of recurrent
describes the most sinopulmonary infections and chronic diarrhea point
appropriate initial to an antibody deficiency syndrome, which should be
laboratory test to evaluate initially screened by means of measurement of serum
a patient with re- current immunoglobulin levels. Lymphocyte
bacterial sinopulmonary immunophenotyping and mitogen proliferation assays
infections and chronic are particularly useful in the evaluation of cellular
diarrhea caused by immunodeficiencies, although B-cell
Giardia lamblia. immunophenotyping has utility as a secondary test in
A. lymphocyte evaluating humoral immunodeficiencies. DHR is used
immunophenotyping to evaluate phagocyte defects in oxidative burst,
B. mitogen-induced which are primarily seen in chronic granulomatous
lymphocyte proliferation disorder.
C. oxidative burst by
dihydrorhodamine 123
(DHR)
D. serum immunoglobulin
levels
Question 1. 1. Answer: A
Concentrations of which Explanation: This is important not only because
of the following allergens control of indoor humidity is important in reducing
are most closely related mite exposure but also because the presence of
to indoor humidity? house dust mites is less in arid climates or at higher
A. Dermatophagoides altitudes.
farinae
B. Blatella germanica
C. Alternaria alternata
D. Felis domesticus
