MLT 106 Review Study Guide with Complete Solutions

MLT 106 Review Study Guide with Complete Solutions What are ABO antigens described as due to individuals producing A/B antigens that are absent from their RBCs? - Answer️️ -Naturally Occuring What class of antibody are ABO antibodies (predominately) - Answer️️ -IgM What class of antibody is the major isotype for O Serum, containing anti A&B? - Answer️️ -IgG What can ABO antibodies cause if the wrong ABO Group is transfused (Transfusion Reaction)? - Answer️️ -Rapid Intravascular Hemolysis What chromosome is the locus for the ABO Gene located on? - Answer️️ - Chromosome 9 What is Gene O considered since there is no detectable antigen? - Answer️️ -Amorph What does the formation of ABH antigens result from? - Answer️️ -Interactions of the genes on three separate loci, (ABO, Hh, and Se). Interactions of the genes ABO, Hh, and Se don't code for the production of ADH, instead they: - Answer️️ -Produce specific glycosyltransferases that add sugars to a basic precursor substance (a paragloboside or glycan) ABH antigens on the RBC are constructed on what? - Answer️️ -Oligosaccharide chains of a type 2 precursor substance ©SOPHIABENNETT EXAM SOLUTIONS Saturday, September 7, 2024 6:58 PM Page | 2 Where are type 1 precursor chains found? - Answer️️ -Secretions, such as plasma, milk, urine, and tears Where is the H gene located? - Answer️️ -Chromosome 19 What is the Type 2 precursor chain made of? - Answer️️ -Binded to the RBC via Ceramide and Glucose, attached to a galactose, N-acetyl-D-galactosamine sugar, galactose. The amount of H antigen in red cells is based on agglutination, and that is represented by: - Answer️️ -OA2BA2BA1A1B O Blood (also the general) Precursor chain diagram makeup: - Answer️️ -Adds L- fucosultransferase (in order to bind a Fructose to the end of the chain, a galactose). A Blood Precursor chain diagram: - Answer️️ -Adds N-acetylgalactosaminyltransferase to the H antigen afflicted chain, therefore binding a N-acetyl-D-Galactosamine sugar to the end. B Blood Precursor chain diagram: - Answer️️ -Adds D-Galactosytransferase, which binds galactose to the H afflicted chain. AB blood precursor chain: - Answer️️ -Has both N-acetylgalactosaminyltransderase and D-Galactosyltransferase to bind both N-acetyl-D-Galactosami