USMLE STEP 1 EXAM QUESTIONS AND
VERIFIED ANSWERS
anti-basement membrane antibodies - diagnosis? Correct Answer
Goodpasture's syndrome
anti-CENTROMERE ABs - diagnosis? Correct Answer
scleroderma (CREST)
anti-dsDNA antibodies (ANA antibodies) - diagnosis?
- what hypersensitivity type? Correct Answer SLE - type III
hypersensitivity
anti-epithelial cell antibodies - diagnosis? Correct Answer
pemphigus vulgaris
antigliadin antibodies - diagnosis? Correct Answer celiac disease
antihistone antibodies - diagnosis? Correct Answer drug-induced
SLE
anti-IgG antibodies - diagnosis? Correct Answer rheumatoid
arthritis
antimitochondrial antibodies - diagnosis? Correct Answer primary
biliary cirrhosis
antineutrophil antibodies - diagnosis? Correct Answer vasculitis
antiplatelet antibodies - diagnosis? Correct Answer ITP -
idiopathic thrombocytopenic purpura
Arnold-Chiari malformation Correct Answer cerebellar tonsillar
herniation
,Aschoff bodies - diagnosis? Correct Answer rheumatic fever
atrophy of the mammillary bodies - diagnosis? Correct Answer
Wernicke's encephalopathy
Auer rods - diagnosis? Correct Answer AML - acute
myelogenous leukemia (especially promyelocytic type)
defective dystrophin, less severe than Duchenne's Correct
Answer Becker's muscular dystrophy
LMN CN 7 palsy Correct Answer Bell's palsy
Bence Jones proteins - possible 2 dxs?
- in each case, what are the proteins? Correct Answer multiple
myeloma - kappa or lambda light chains
Waldenstrom's macroglobulinemia - IgM
IgA nephropathy - diagnosis? Correct Answer Berger's disease
Bernard-Soulier disease - what is the defect? Correct Answer
defect in platelet adhesion
Birbeck granules on EM - diagnosis? Correct Answer
histiocytosis X (eosinophilic granuloma)
blue-domed cysts - diagnosis? Correct Answer fibrocystic change
of the breast
boot-shaped heart on x-ray - possible diagnoses? Correct Answer
tetralogy of Fallot or RVH
Bouchard's nodes - diagnosis?
- where are they located?
,- why do they occur? Correct Answer osteoarthritis - on PIP
secondary to osteophytes
boutonniere deformity - diagnosis? Correct Answer rheumatoid
arthritis
"brown tumor" of bone - possible diagnoses?
- what causes the brown color? Correct Answer
hyperparathyroidism or osteitis fibrosa cystica (von
Recklinghausen's disease)
- color is due to hemorrhage in cysts
X-linked agammaglobulinemia Correct Answer Bruton's disease
posthepatic venous thrombosis - diagnosis? Correct Answer
Budd-Chiari syndrome
Buerger's disease - what size arteries? Correct Answer small or
medium-artery vasculitis
Burkitt's lymphoma - translocation?
- what virus?
- appearance on histology? Correct Answer 8:14 translocation
EBV
starry sky appearance
Burton's lines - diagnosis? Correct Answer lead poisoning
what types of ANCA are associated with Wegener's
granulomatosis & microscopic polyangiitis? Correct Answer
Wegener's - c-ANCA
MPA - p-ANCA
cafe-au-lait spots on skin - diagnosis? Correct Answer
neurofibromatosis
, Call-Exner bodies - diagnosis? Correct Answer granulosa-theca
cell ovarian tumor "call granny exner"
cardiomegaly with apical atrophy - diagnosis? Correct Answer
Chagas' disease
trypanosome infection - diagnosis? Correct Answer Chagas'
disease
painful chancroid - cause? Correct Answer Haemophilus ducreyi
Charcot's triad of multiple sclerosis Correct Answer nystagmus,
intention tremor, scanning speech
Charcot's triad of cholangitis Correct Answer jaundice, RUQ pain,
fever
Charcot-Leyden crystals - diagnosis?
- what are they? Correct Answer bronchial asthma - eosinophil
membranes
defect in Chediak-Higashi? Correct Answer phagocyte deficiency
what are Cheyne-Stokes respirations, and in what circumstance
do they occur? Correct Answer central apnea in CHF and
increased intracranial pressure
what does chronic atrophic gastritis predispose to? Correct
Answer gastric carcinoma
DES exposure in utero predisposes to what? Correct Answer
clear cell aDENocarcinoma of the vagina
VERIFIED ANSWERS
anti-basement membrane antibodies - diagnosis? Correct Answer
Goodpasture's syndrome
anti-CENTROMERE ABs - diagnosis? Correct Answer
scleroderma (CREST)
anti-dsDNA antibodies (ANA antibodies) - diagnosis?
- what hypersensitivity type? Correct Answer SLE - type III
hypersensitivity
anti-epithelial cell antibodies - diagnosis? Correct Answer
pemphigus vulgaris
antigliadin antibodies - diagnosis? Correct Answer celiac disease
antihistone antibodies - diagnosis? Correct Answer drug-induced
SLE
anti-IgG antibodies - diagnosis? Correct Answer rheumatoid
arthritis
antimitochondrial antibodies - diagnosis? Correct Answer primary
biliary cirrhosis
antineutrophil antibodies - diagnosis? Correct Answer vasculitis
antiplatelet antibodies - diagnosis? Correct Answer ITP -
idiopathic thrombocytopenic purpura
Arnold-Chiari malformation Correct Answer cerebellar tonsillar
herniation
,Aschoff bodies - diagnosis? Correct Answer rheumatic fever
atrophy of the mammillary bodies - diagnosis? Correct Answer
Wernicke's encephalopathy
Auer rods - diagnosis? Correct Answer AML - acute
myelogenous leukemia (especially promyelocytic type)
defective dystrophin, less severe than Duchenne's Correct
Answer Becker's muscular dystrophy
LMN CN 7 palsy Correct Answer Bell's palsy
Bence Jones proteins - possible 2 dxs?
- in each case, what are the proteins? Correct Answer multiple
myeloma - kappa or lambda light chains
Waldenstrom's macroglobulinemia - IgM
IgA nephropathy - diagnosis? Correct Answer Berger's disease
Bernard-Soulier disease - what is the defect? Correct Answer
defect in platelet adhesion
Birbeck granules on EM - diagnosis? Correct Answer
histiocytosis X (eosinophilic granuloma)
blue-domed cysts - diagnosis? Correct Answer fibrocystic change
of the breast
boot-shaped heart on x-ray - possible diagnoses? Correct Answer
tetralogy of Fallot or RVH
Bouchard's nodes - diagnosis?
- where are they located?
,- why do they occur? Correct Answer osteoarthritis - on PIP
secondary to osteophytes
boutonniere deformity - diagnosis? Correct Answer rheumatoid
arthritis
"brown tumor" of bone - possible diagnoses?
- what causes the brown color? Correct Answer
hyperparathyroidism or osteitis fibrosa cystica (von
Recklinghausen's disease)
- color is due to hemorrhage in cysts
X-linked agammaglobulinemia Correct Answer Bruton's disease
posthepatic venous thrombosis - diagnosis? Correct Answer
Budd-Chiari syndrome
Buerger's disease - what size arteries? Correct Answer small or
medium-artery vasculitis
Burkitt's lymphoma - translocation?
- what virus?
- appearance on histology? Correct Answer 8:14 translocation
EBV
starry sky appearance
Burton's lines - diagnosis? Correct Answer lead poisoning
what types of ANCA are associated with Wegener's
granulomatosis & microscopic polyangiitis? Correct Answer
Wegener's - c-ANCA
MPA - p-ANCA
cafe-au-lait spots on skin - diagnosis? Correct Answer
neurofibromatosis
, Call-Exner bodies - diagnosis? Correct Answer granulosa-theca
cell ovarian tumor "call granny exner"
cardiomegaly with apical atrophy - diagnosis? Correct Answer
Chagas' disease
trypanosome infection - diagnosis? Correct Answer Chagas'
disease
painful chancroid - cause? Correct Answer Haemophilus ducreyi
Charcot's triad of multiple sclerosis Correct Answer nystagmus,
intention tremor, scanning speech
Charcot's triad of cholangitis Correct Answer jaundice, RUQ pain,
fever
Charcot-Leyden crystals - diagnosis?
- what are they? Correct Answer bronchial asthma - eosinophil
membranes
defect in Chediak-Higashi? Correct Answer phagocyte deficiency
what are Cheyne-Stokes respirations, and in what circumstance
do they occur? Correct Answer central apnea in CHF and
increased intracranial pressure
what does chronic atrophic gastritis predispose to? Correct
Answer gastric carcinoma
DES exposure in utero predisposes to what? Correct Answer
clear cell aDENocarcinoma of the vagina
