,Practical Transfusion Medicine
k k
,Practical Transfusion Medicine k k
FIFTH EDITION k
Edited By k
Michael F. Murphy, MD, FRCP, FRCPath, FFPath
k k k k k k
Professor of Blood Transfusion Medicine
k k k k
University of Oxford
k k k
Consultant Haematologist k
NHS Blood and Transplant and Department of Haematology, Oxford University Hospitals
k k k k k k k k k k
Oxford,UK
k k
David J. Roberts, MB, ChB, D.Phil, FRCPath
k k k k k k
Professor of Haematology k k
University of Oxford
k k k
Consultant Haematologist
k k
NHS Blood and Transplant and Department of Haematology, Oxford University Hospitals
k k k k k k k k k k
Oxford,UK
k k
Mark H. Yazer, MD
k k k
kProfessor of Pathology k k
University of Pittsburgh
k k k
Adjunct Professor of Clinical Immunology
k k k k
University of Southern Denmark
k k k k
Odense, Denmark k
Medical Director
k k
RBC Serology Reference Laboratory, ITXM Centralized Transfusion
k k k k k k
kServiceAssociateMedicalDirector
k k k
ITXM Centralized Transfusion Service
k k k
Pittsburgh, USA
k k
, This edition first published 2017
k k k k
© 2001, 2005, 2009, 2013 by John Wiley & Sons Ltd
k k k k k k k k k k
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any
k k k k k k k k k k k k k k k k k k k
form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law.
k k k k k k k k k k k k k k k k
Advice on how to obtain permission to reuse material from this title is available at www.wiley.com/go/permissions.
k k k k k k k k k k k k k k k k
The right of Michael F. Murphy, David J. Roberts, and Mark H. Yazer to be identified as the author(s) of this has
k k k k k k k k k k k k k k k k k k k k k
been asserted in accordance with law.
k k k k k k
Registered Offices k
John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA
k k k k k k k k k k k
John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK
k k k k k k k k k k k k k k
Editorial Office k
9600 Garsington Road, Oxford, OX4 2DQ, UK
k k k k k k
For details of our global editorial offices, customer services, and more information about Wiley
k k k k k k k k k k k k k
kproducts visit us at www.wiley.com. k k k k
Wiley also publishes its books in a variety of electronic formats and by print‐on‐demand. Some content that appears in
k k k k k k k k k k k k k k k k k k
standard print versions of this book may not be available in other formats.
k k k k k k k k k k k k k
Limit of Liability/Disclaimer of Warranty
k k k k
The contents of this work are intended to further general scientific research, understanding, and discussion only
k k k k k k k k k k k k k k k
kand arenot intended and should not be relied upon as recommending or promoting scientific method, diagnosis, or
k k k k k k k k k k k k k k k k k
ktreatment byphysicians for any particular patient. The publisher and the authors make no representations or
k k k k k k k k k k k k k k k
kwarranties with respect to the accuracy and completeness of the contents of this work and specifically disclaim all
k k k k k k k k k k k k k k k k k
kwarranties, including without k k
limitation any implied warranties of fitness for a particular purpose. In view of ongoing research, equipment
k k k k k k k k k k k k k k k
kmodifications, changes in governmental regulations, and the constant flow of information relating to the use of
k k k k k k k k k k k k k k k
kmedicines, equipment, and devices, the reader is urged to review and evaluate the information provided in the
k k k k k k k k k k k k k k k k
kpackage insert or instructions for each medicine, equipment, or device for, among other things, any changes in the
k k k k k k k k k k k k k k k k k
kinstructions or indication of usage and for added warnings and precautions. Readers should consult with a specialist
k k k k k k k k k k k k k k k k
kwhere appropriate. The fact that an organization or website is referred to in this work as a citation and/or potential
k k k k k k k k k k k k k k k k k k k
ksource of further information does not mean that the authors or the publisher endorses the information the
k k k k k k k k k k k k k k k k
korganization or website may provide or recommendations it may make. Further, readers should be aware that
k k k k k k k k k k k k k k k
kwebsites listed in this work may have changed or disappeared between when this works was written and when it is
k k k k k k k k k k k k k k k k k k k
kread. No warranty may be created or extended by any promotional statements for thiswork. Neither the publisher nor
k k k k k k k k k k k k k k k k k k
kthe authors shall be liable for any damages arising herefrom.
k k k k k k k k k
Library of Congress Cataloging‐in‐Publication Data
k k k k
Names: Murphy, Michael F. (Michael Furber), editor. | Roberts, David J. (David John)
k k k k k k k k k k k k
(Consultant hematologist), editor. | Yazer, Mark H., editor.
k k k k k k k k
Title: Practical transfusion medicine / edited by Michael F. Murphy, David J. Roberts, Mark H.
k k k k k k k k k k k k k k
kYazer. Description: Fifth edition. | Hoboken, NJ : John Wiley & Sons Inc., 2017. |
k k k k k k k k k k k k k k
Preceded by Practical transfusion medicine / edited by Michael F.
k k k k k k k k k
Murphy,Derwood H. Pamphilon, Nancy M. Heddle. 4th ed. 2013. |
k k k k k k k k k k k
Includes bibliographical references and index. k k k k
Identifiers: LCCN 2016053360 | ISBN 9781119129417 (cloth) | ISBN 9781119129448 (Adobe pdf)
k k k k k k k k k k k
|ISBN 9781119129424 (epub)
k k k k
Subjects: | MESH: Blood Transfusion | Blood Grouping and Crossmatching
k k k k k k k k k
|Hematopoietic Stem Cell Transplantation | Blood Preservation |
k k k k k k k k k
Cross Infection–prevention & control k k k
Classification: LCC RM171 | NLM WB 356 | DDC 615.3/9– k k k k k k k k k
dc23LC record available at https://lccn.loc.gov/2016053360
k k k k k
Set in 10/12pt Warnock by SPi Global, Pondicherry, India
k k k k k k k k
10 k k k 9 k k k k 8 k k k k 7 k k k k 6 k k k k 5 k k k k 4 k k k k 3 k k k k 2 k k k k 1
k k
,Practical Transfusion Medicine k k
FIFTH EDITION k
Edited By k
Michael F. Murphy, MD, FRCP, FRCPath, FFPath
k k k k k k
Professor of Blood Transfusion Medicine
k k k k
University of Oxford
k k k
Consultant Haematologist k
NHS Blood and Transplant and Department of Haematology, Oxford University Hospitals
k k k k k k k k k k
Oxford,UK
k k
David J. Roberts, MB, ChB, D.Phil, FRCPath
k k k k k k
Professor of Haematology k k
University of Oxford
k k k
Consultant Haematologist
k k
NHS Blood and Transplant and Department of Haematology, Oxford University Hospitals
k k k k k k k k k k
Oxford,UK
k k
Mark H. Yazer, MD
k k k
kProfessor of Pathology k k
University of Pittsburgh
k k k
Adjunct Professor of Clinical Immunology
k k k k
University of Southern Denmark
k k k k
Odense, Denmark k
Medical Director
k k
RBC Serology Reference Laboratory, ITXM Centralized Transfusion
k k k k k k
kServiceAssociateMedicalDirector
k k k
ITXM Centralized Transfusion Service
k k k
Pittsburgh, USA
k k
, This edition first published 2017
k k k k
© 2001, 2005, 2009, 2013 by John Wiley & Sons Ltd
k k k k k k k k k k
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any
k k k k k k k k k k k k k k k k k k k
form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law.
k k k k k k k k k k k k k k k k
Advice on how to obtain permission to reuse material from this title is available at www.wiley.com/go/permissions.
k k k k k k k k k k k k k k k k
The right of Michael F. Murphy, David J. Roberts, and Mark H. Yazer to be identified as the author(s) of this has
k k k k k k k k k k k k k k k k k k k k k
been asserted in accordance with law.
k k k k k k
Registered Offices k
John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA
k k k k k k k k k k k
John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK
k k k k k k k k k k k k k k
Editorial Office k
9600 Garsington Road, Oxford, OX4 2DQ, UK
k k k k k k
For details of our global editorial offices, customer services, and more information about Wiley
k k k k k k k k k k k k k
kproducts visit us at www.wiley.com. k k k k
Wiley also publishes its books in a variety of electronic formats and by print‐on‐demand. Some content that appears in
k k k k k k k k k k k k k k k k k k
standard print versions of this book may not be available in other formats.
k k k k k k k k k k k k k
Limit of Liability/Disclaimer of Warranty
k k k k
The contents of this work are intended to further general scientific research, understanding, and discussion only
k k k k k k k k k k k k k k k
kand arenot intended and should not be relied upon as recommending or promoting scientific method, diagnosis, or
k k k k k k k k k k k k k k k k k
ktreatment byphysicians for any particular patient. The publisher and the authors make no representations or
k k k k k k k k k k k k k k k
kwarranties with respect to the accuracy and completeness of the contents of this work and specifically disclaim all
k k k k k k k k k k k k k k k k k
kwarranties, including without k k
limitation any implied warranties of fitness for a particular purpose. In view of ongoing research, equipment
k k k k k k k k k k k k k k k
kmodifications, changes in governmental regulations, and the constant flow of information relating to the use of
k k k k k k k k k k k k k k k
kmedicines, equipment, and devices, the reader is urged to review and evaluate the information provided in the
k k k k k k k k k k k k k k k k
kpackage insert or instructions for each medicine, equipment, or device for, among other things, any changes in the
k k k k k k k k k k k k k k k k k
kinstructions or indication of usage and for added warnings and precautions. Readers should consult with a specialist
k k k k k k k k k k k k k k k k
kwhere appropriate. The fact that an organization or website is referred to in this work as a citation and/or potential
k k k k k k k k k k k k k k k k k k k
ksource of further information does not mean that the authors or the publisher endorses the information the
k k k k k k k k k k k k k k k k
korganization or website may provide or recommendations it may make. Further, readers should be aware that
k k k k k k k k k k k k k k k
kwebsites listed in this work may have changed or disappeared between when this works was written and when it is
k k k k k k k k k k k k k k k k k k k
kread. No warranty may be created or extended by any promotional statements for thiswork. Neither the publisher nor
k k k k k k k k k k k k k k k k k k
kthe authors shall be liable for any damages arising herefrom.
k k k k k k k k k
Library of Congress Cataloging‐in‐Publication Data
k k k k
Names: Murphy, Michael F. (Michael Furber), editor. | Roberts, David J. (David John)
k k k k k k k k k k k k
(Consultant hematologist), editor. | Yazer, Mark H., editor.
k k k k k k k k
Title: Practical transfusion medicine / edited by Michael F. Murphy, David J. Roberts, Mark H.
k k k k k k k k k k k k k k
kYazer. Description: Fifth edition. | Hoboken, NJ : John Wiley & Sons Inc., 2017. |
k k k k k k k k k k k k k k
Preceded by Practical transfusion medicine / edited by Michael F.
k k k k k k k k k
Murphy,Derwood H. Pamphilon, Nancy M. Heddle. 4th ed. 2013. |
k k k k k k k k k k k
Includes bibliographical references and index. k k k k
Identifiers: LCCN 2016053360 | ISBN 9781119129417 (cloth) | ISBN 9781119129448 (Adobe pdf)
k k k k k k k k k k k
|ISBN 9781119129424 (epub)
k k k k
Subjects: | MESH: Blood Transfusion | Blood Grouping and Crossmatching
k k k k k k k k k
|Hematopoietic Stem Cell Transplantation | Blood Preservation |
k k k k k k k k k
Cross Infection–prevention & control k k k
Classification: LCC RM171 | NLM WB 356 | DDC 615.3/9– k k k k k k k k k
dc23LC record available at https://lccn.loc.gov/2016053360
k k k k k
Set in 10/12pt Warnock by SPi Global, Pondicherry, India
k k k k k k k k
10 k k k 9 k k k k 8 k k k k 7 k k k k 6 k k k k 5 k k k k 4 k k k k 3 k k k k 2 k k k k 1