BSMCON Pathopharm I test with
Complete Solutions |Latest Update
Questions 2024-2025
What are clinical considerations for bile acid sequestrants/resins? - ANSWER -take before meals
-take other medications 2 hours before or 4 hours after taking bile sequestrants (will block
absorption)
-increase bulk and fluid in diet for constipation prevention
-mix with 60 mL- 180 mL of water, juices, or pulpy fruits
-drink IMMEDIATELY to avoid GI irritation
What is the mechanism of action for ezetimibe? - ANSWER -inhibits cholesterol absorption in
the small intestine
-blocks absorption of both dietary (exogenous) and bile-secreted (endogenous) cholesterol,
"food and family"
-oral
-often given with statins
-slight increased risk of liver damage, myopathy with statins
What is the mechanism of action for fibric acid agents? - ANSWER -active lipoprotein lipase
which increases the breakdown and elimination of triglyceride rich particles from the plasma
-prototypes: gemfibrozil; fenofibrate
What are the adverse effects of fibric acid agents? - ANSWER -dyspepsia
-diarrhea
-nausea
-cramping
,What are the drug interaction for fibric acid agents? - ANSWER -do NOT give gemfibrozil
with statins (increased risk of myopathy)
-can give fenofibrate with statins if needed for high triglycerides
-increased warfarin effects- monitor INR
-increased effects of hypoglycemic medications (monitor glucose levels)
Your patient was started on cholestyramine for high LDL three months ago. She states that
her bad cholesterol has improved but her hypothyroidism has worsened (increased TSH).
What question(s) should you ask this patient in relation to cholestyramine and its use?
A) Do you have a history of renal impairment?
B) Have you ever had your liver function tests completed recently?
C) At what time are you taking your medication?
D) Do you have any muscle pain? - ANSWER Correct: C.
All of the following are appropriate patient teaching points regarding statins, except:
A) "Statins are teratogenic, so talk to your doctor well in advance of trying to concieve and use
contraception."
B) "Let your doctor know if you experience any muscle pain."
, C) Most statins should be taken at night before bed."
D) "Statins do not have anydrug interactions with food" - ANSWER Correct: D
What are some major injurious agents to endothelium? - ANSWER -hypertension
-hyperglycemia
-hypercholesterolemia
What is Arteriosclerosis? - ANSWER a chronic disease of the arterial system; thickening and
hardening of vessel walls- calcification
What are outcomes of atherosclerosis? - ANSWER -coronary artery disease
-cerebrovascular disease
-heart attack
-stroke
-peripheral vascular disease
-aneurysms
-embolism
What is atherosclerosis treatment? - ANSWER -stabilize plaque and prevent thrombus
-LIPID LOWERING WITH STATINS!
other methods:
-ASA
-ACEI/ARB
-fish oil
Complete Solutions |Latest Update
Questions 2024-2025
What are clinical considerations for bile acid sequestrants/resins? - ANSWER -take before meals
-take other medications 2 hours before or 4 hours after taking bile sequestrants (will block
absorption)
-increase bulk and fluid in diet for constipation prevention
-mix with 60 mL- 180 mL of water, juices, or pulpy fruits
-drink IMMEDIATELY to avoid GI irritation
What is the mechanism of action for ezetimibe? - ANSWER -inhibits cholesterol absorption in
the small intestine
-blocks absorption of both dietary (exogenous) and bile-secreted (endogenous) cholesterol,
"food and family"
-oral
-often given with statins
-slight increased risk of liver damage, myopathy with statins
What is the mechanism of action for fibric acid agents? - ANSWER -active lipoprotein lipase
which increases the breakdown and elimination of triglyceride rich particles from the plasma
-prototypes: gemfibrozil; fenofibrate
What are the adverse effects of fibric acid agents? - ANSWER -dyspepsia
-diarrhea
-nausea
-cramping
,What are the drug interaction for fibric acid agents? - ANSWER -do NOT give gemfibrozil
with statins (increased risk of myopathy)
-can give fenofibrate with statins if needed for high triglycerides
-increased warfarin effects- monitor INR
-increased effects of hypoglycemic medications (monitor glucose levels)
Your patient was started on cholestyramine for high LDL three months ago. She states that
her bad cholesterol has improved but her hypothyroidism has worsened (increased TSH).
What question(s) should you ask this patient in relation to cholestyramine and its use?
A) Do you have a history of renal impairment?
B) Have you ever had your liver function tests completed recently?
C) At what time are you taking your medication?
D) Do you have any muscle pain? - ANSWER Correct: C.
All of the following are appropriate patient teaching points regarding statins, except:
A) "Statins are teratogenic, so talk to your doctor well in advance of trying to concieve and use
contraception."
B) "Let your doctor know if you experience any muscle pain."
, C) Most statins should be taken at night before bed."
D) "Statins do not have anydrug interactions with food" - ANSWER Correct: D
What are some major injurious agents to endothelium? - ANSWER -hypertension
-hyperglycemia
-hypercholesterolemia
What is Arteriosclerosis? - ANSWER a chronic disease of the arterial system; thickening and
hardening of vessel walls- calcification
What are outcomes of atherosclerosis? - ANSWER -coronary artery disease
-cerebrovascular disease
-heart attack
-stroke
-peripheral vascular disease
-aneurysms
-embolism
What is atherosclerosis treatment? - ANSWER -stabilize plaque and prevent thrombus
-LIPID LOWERING WITH STATINS!
other methods:
-ASA
-ACEI/ARB
-fish oil
