Test Bank For Pharmacology: An Introduction 7th Edition By
Henry Hitner , Barbara Nagle 9781259718564 ALL Chapters .
Identify the main function of macrophages - ANSWER: Macrophages are scavenger cells that engulf
and digest infectious organisms and foreign substances
Identify the role of helper T-cell lymphocytes in regulating the activity of the immune system -
ANSWER: The function of helper T-cells is to recognize the foreign antigens presented to them by
macrophages and other antigen-presenting cells
Which of the following diseases is an immune-based disease that is treated by suppressing the
immune response? - ANSWER: Multiple sclerosis
Myasthenia gravis
Systemic lupus erythematosus
Which of the following is the main immunosuppressive effect of the corticosteroids? - ANSWER: The
corticosteroids cause lymphocytes in the blood to be redistributed into the bone marrow
Identify the statement that best explains how azathioprine (Imuran) works to treat lupus
erythematosus - ANSWER: Azathioprine {prevents} the production of adenine and guanine, which
leads to the suppression of existing lymphocytes and suppresses the formation of new B-cells and T-
cells
Identify the clinical indications for the use of mycophenolate mofetil (CellCept) - ANSWER:
Mycophenolate mofetil is used in renal organ transplantation to prevent rejection.
The use of infliximab (Remicade) leads to an infusion reaction that - ANSWER: can include fever, chills,
hives, hypotension, and chest pain
The common adverse effects of the use of interferons are - ANSWER: flu-like symptoms such as chills,
fever, and muscle aches and pains
Select the statement that accurately describes the difference between immunomodulation and
immunosuppression - ANSWER: All of these are correct
Identify the statement that accurately explains the symptoms that a patient being administered
filgrastim (Neupogen) should report to the physician - ANSWER: The patient should immediately
report to the physician any fever, chills, GI disturbances, and muscle and bone pain
Identify the true statement about macrophages - ANSWER: Macrophages are classified as antigen-
presenting cells
Select the false statement related to the adverse effects of azathioprine and the other cytotoxic drugs
- ANSWER: None of these are false
Select the statement that is correct about tacrolimus (Prograf) and cyclosporine (Sandimmune) -
ANSWER: Tacrolimus and cyclosporine inhibit the T-cell lymphocyte activity
Select the true statement about the difference between the actions of interleukin-2 (Proleukin) and
that of colony stimulating factors (CSF) - ANSWER: Interleukin-2 stimulates B-cell production of
antibodies and killer T-cell activity, whereas {CSFs stimulate the bone marrow} to increase the
production of macrophages and granulocytes
Select the true statement about the mechanism of action of a natural killer cell - ANSWER: The natural
killer cell releases perforins that form a hole in the enemy cell membrane
Granzymes from the natural killer cell enter the perforin hole and degrade the enemy cell enzymes
, The enemy cell dies by apoptosis, and the macrophage engulfs and digests the dying cell
Select the false statement about the effect of lymphopenia on the immune response following
administration of immunosuppressive drugs like the corticosteroids - ANSWER: Corticosteroids
increase the amount of lymphoid tissue and cells in the lymph nodes and spleen
Select the false statement about memory cells and their role in the immune response process in the
body - ANSWER: Memory cells are lymphocytes that inhibit the activity of the immune system when
the immune response is no longer needed
Memory cells remain in the body for many years and can quickly become reactivated to produce an
immune response against an organism that previously infected the body - ANSWER: None of these are
false
Select the true statement related to the alkylating drug cyclosporine (Sandimmune) - ANSWER:
Cyclosporine inhibits the production of interleukin-2
Select the true statement about infliximab (Remicade) - ANSWER: Infliximab is a monoclonal antibody
that binds to and inhibits the activity of tumor necrosis factor (TNF-alpha)
Samuel, who has been diagnosed with lupus erythematosus, is prescribed a cytotoxic drug. His doctor
explains that the drug is converted in the body to mercaptopurine, which exerts a cytotoxic effect. It
inhibits the synthesis of purine nucleotides that are required for DNA synthesis. Which of the
following drugs has Samuel been prescribed? - ANSWER: Azathioprine
Ethan is scheduled for an organ transplant. He is administered a drug to prevent organ rejection. The
drug works by suppressing T-cell function. Which of the following drugs has Ethan been administered?
- ANSWER: Sandimmune
Logan is diagnosed with rheumatoid arthritis. He is prescribed a drug that is to be taken orally. Logan
is informed by his doctor that the drug has a half-life of 15 days. He also explains that he may
experience diarrhea. Which of the following drugs has Logan been prescribed? - ANSWER: Arava
Gabriel is diagnosed with hairy cell leukemia. He is prescribed an immunomodulating agent that is
administered through intramuscular injections. Which of the following drugs has Gabriel been
prescribed? - ANSWER: Intron A
Fatima is suffering from multiple sclerosis. She is being administered a drug through subcutaneous
injections three times a week. Which of the following drugs is Fatima being administered? - ANSWER:
Avonex
_____ is an immunomodulating agent that is administered through slow IV infusion to treat renal cell
cancer - ANSWER: Proleukin
_____ is an immunomodulating agent that is used to treat Kaposi's sarcoma - ANSWER: Roferon-A
_____ is administered using intralesional injections and is used to treat the human papillomavirus
(HPV) infection - ANSWER: Alferon N
_____ is administered using subcutaneous injections to treat chronic hepatitis C - ANSWER: Infergen
_____ is administered using subcutaneous injections three times a week to treat chronic
granulomatous disease - ANSWER: Actimmune
_____ is administered using subcutaneous injections to treat chronic myelogenous leukemia -
ANSWER: Roferon-A
Henry Hitner , Barbara Nagle 9781259718564 ALL Chapters .
Identify the main function of macrophages - ANSWER: Macrophages are scavenger cells that engulf
and digest infectious organisms and foreign substances
Identify the role of helper T-cell lymphocytes in regulating the activity of the immune system -
ANSWER: The function of helper T-cells is to recognize the foreign antigens presented to them by
macrophages and other antigen-presenting cells
Which of the following diseases is an immune-based disease that is treated by suppressing the
immune response? - ANSWER: Multiple sclerosis
Myasthenia gravis
Systemic lupus erythematosus
Which of the following is the main immunosuppressive effect of the corticosteroids? - ANSWER: The
corticosteroids cause lymphocytes in the blood to be redistributed into the bone marrow
Identify the statement that best explains how azathioprine (Imuran) works to treat lupus
erythematosus - ANSWER: Azathioprine {prevents} the production of adenine and guanine, which
leads to the suppression of existing lymphocytes and suppresses the formation of new B-cells and T-
cells
Identify the clinical indications for the use of mycophenolate mofetil (CellCept) - ANSWER:
Mycophenolate mofetil is used in renal organ transplantation to prevent rejection.
The use of infliximab (Remicade) leads to an infusion reaction that - ANSWER: can include fever, chills,
hives, hypotension, and chest pain
The common adverse effects of the use of interferons are - ANSWER: flu-like symptoms such as chills,
fever, and muscle aches and pains
Select the statement that accurately describes the difference between immunomodulation and
immunosuppression - ANSWER: All of these are correct
Identify the statement that accurately explains the symptoms that a patient being administered
filgrastim (Neupogen) should report to the physician - ANSWER: The patient should immediately
report to the physician any fever, chills, GI disturbances, and muscle and bone pain
Identify the true statement about macrophages - ANSWER: Macrophages are classified as antigen-
presenting cells
Select the false statement related to the adverse effects of azathioprine and the other cytotoxic drugs
- ANSWER: None of these are false
Select the statement that is correct about tacrolimus (Prograf) and cyclosporine (Sandimmune) -
ANSWER: Tacrolimus and cyclosporine inhibit the T-cell lymphocyte activity
Select the true statement about the difference between the actions of interleukin-2 (Proleukin) and
that of colony stimulating factors (CSF) - ANSWER: Interleukin-2 stimulates B-cell production of
antibodies and killer T-cell activity, whereas {CSFs stimulate the bone marrow} to increase the
production of macrophages and granulocytes
Select the true statement about the mechanism of action of a natural killer cell - ANSWER: The natural
killer cell releases perforins that form a hole in the enemy cell membrane
Granzymes from the natural killer cell enter the perforin hole and degrade the enemy cell enzymes
, The enemy cell dies by apoptosis, and the macrophage engulfs and digests the dying cell
Select the false statement about the effect of lymphopenia on the immune response following
administration of immunosuppressive drugs like the corticosteroids - ANSWER: Corticosteroids
increase the amount of lymphoid tissue and cells in the lymph nodes and spleen
Select the false statement about memory cells and their role in the immune response process in the
body - ANSWER: Memory cells are lymphocytes that inhibit the activity of the immune system when
the immune response is no longer needed
Memory cells remain in the body for many years and can quickly become reactivated to produce an
immune response against an organism that previously infected the body - ANSWER: None of these are
false
Select the true statement related to the alkylating drug cyclosporine (Sandimmune) - ANSWER:
Cyclosporine inhibits the production of interleukin-2
Select the true statement about infliximab (Remicade) - ANSWER: Infliximab is a monoclonal antibody
that binds to and inhibits the activity of tumor necrosis factor (TNF-alpha)
Samuel, who has been diagnosed with lupus erythematosus, is prescribed a cytotoxic drug. His doctor
explains that the drug is converted in the body to mercaptopurine, which exerts a cytotoxic effect. It
inhibits the synthesis of purine nucleotides that are required for DNA synthesis. Which of the
following drugs has Samuel been prescribed? - ANSWER: Azathioprine
Ethan is scheduled for an organ transplant. He is administered a drug to prevent organ rejection. The
drug works by suppressing T-cell function. Which of the following drugs has Ethan been administered?
- ANSWER: Sandimmune
Logan is diagnosed with rheumatoid arthritis. He is prescribed a drug that is to be taken orally. Logan
is informed by his doctor that the drug has a half-life of 15 days. He also explains that he may
experience diarrhea. Which of the following drugs has Logan been prescribed? - ANSWER: Arava
Gabriel is diagnosed with hairy cell leukemia. He is prescribed an immunomodulating agent that is
administered through intramuscular injections. Which of the following drugs has Gabriel been
prescribed? - ANSWER: Intron A
Fatima is suffering from multiple sclerosis. She is being administered a drug through subcutaneous
injections three times a week. Which of the following drugs is Fatima being administered? - ANSWER:
Avonex
_____ is an immunomodulating agent that is administered through slow IV infusion to treat renal cell
cancer - ANSWER: Proleukin
_____ is an immunomodulating agent that is used to treat Kaposi's sarcoma - ANSWER: Roferon-A
_____ is administered using intralesional injections and is used to treat the human papillomavirus
(HPV) infection - ANSWER: Alferon N
_____ is administered using subcutaneous injections to treat chronic hepatitis C - ANSWER: Infergen
_____ is administered using subcutaneous injections three times a week to treat chronic
granulomatous disease - ANSWER: Actimmune
_____ is administered using subcutaneous injections to treat chronic myelogenous leukemia -
ANSWER: Roferon-A
