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MCB4271 - Exam 1 MoAs Study Guide

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MCB4271 - Exam 1 MoAs Study Guide
beta-lactam ring - Answer

PBPs use ____ as a substrate for peptidoglycan synthesis - Answer D-Ala-D-Ala

5 classes of beta lactam antibiotics and where are they derived from? - Answer
Pencillins - mold

Cephalosporins - mold

Carbapenems - bacteria

Monobactams - bacteria

Clavams - bacteria

Penicillin G - Answer delivered intravenously, disc 1928

*narrow spectrum*

Penicillin V - Answer delivered orally, disc 1948

*narrow spectrum*

Ampicillin - Answer disc 1961

*broad spectrum*

Amoxicillin - Answer disc 1972

*broad spectrum*

Methicillin - Answer disc 1960

*narrow spectrum*

Cephalosporin - Answer derived from mold

more effective than Penicillins (less likely to be attacked by penicillinases i.e. more
resistant)

Carbapenems - Answer bacteria

*broad spectrum, effective against 98% of bacteria, reserved for high risk infection*

Monobactams - Answer single 4 member beta-lactam ring

*target Gram -*

Clavams - Answer not potent, mimic B-lactam Ab, trick and saturate B-lactamases

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