N5315 Advanced Pathophysiology-
Hypersensitivities Latest Update Questions
with Correct Answers
A person with Type A blood has what antibodies? - Answer -B
A person with Type A blood has what antigen? - Answer -A antigen
A person with Type AB blood has what antibodies? - Answer -None
A person with Type AB blood has what antigens? - Answer -AB
A person with Type B blood has what antibodies? - Answer -A
A person with Type B blood has what antigen? - Answer -B antigen
A person with Type O blood has what antibodies? - Answer -AB
A person with Type O blood has what antigen? - Answer -None
How do we prevent Rh incompatibility reactions? - Answer -Administer Rh immune globulin
(Rhogam) within 72 hours of the initial birth
How is Type III hypersensitivity different from Type II hypersensitivity? - Answer -Type III is not
specific to a cell or tissue. The antigen antibody complexes are spread via circulation throughout the
body and generate a more diffuse reaction.
How is Type III hypersensitivity similar to Type II hypersensitivity? - Answer -They are both IgG and
IgM mediated responses.
How long do Type I hypersensitivity reactions occur after exposure to the allergen? - Answer -
Minutes to hours from time of exposure
How many types of hypersensitivities are there? - Answer -4 types; Types 1-4
What antigen does a person who is Rh negative have? - Answer -None
What antigen does a person who is Rh positive have? - Answer -Rh antigen
What are clinical manifestations of Systemic Lupus Erythematosus? - Answer -They include
butterfly rash (localized to cheeks), photosensitivity, nonerosive arthritis of at least 2 peripheral joints,
serositis, proteinuria, seizures, anemia, leukopenia, and thrombocytopenia. Symptoms and intensity may
vary, with no way of predicting either.
What are examples of Type IV hypersensitivity? - Answer -Contact dermatitis, reactive tuberculin
skin test, and solid organ transplant rejection
, What are most Type I hypersensitivity reactions attributed to? - Answer -Allergies to food,
medication, pollen, etc.
What are some autoimmune examples of Type II hypersensitivities? - Answer -Graves' disease,
Myasthenia Gravis, and Guillain-Barre' Syndrome
What are some examples of Type I hypersensitivities? - Answer -Environmental allergies, asthma
exacerbation, food allergies, drug allergies, animal allergies, and insect venom allergies
Angioedema which causes swelling of lips, eyes, and larynx. (Anaphylaxis is most severe reaction. Is
treated with epinephrine).
Atopic Disorders include hay fever, asthma, eczema, and urticarial. They have strong genetic disposition.
What are some examples of Type II hypersensitivities? - Answer -ABO incompatibilty and Rh
incompatibility
What are some examples of Type III hypersensitivities? - Answer -Systemic Lupus Erythematosus
and Rheumatoid Arthritis
What are the 4 blood types? - Answer -A, B, AB, O
What are the clinical manifestations of Rheumatoid Arthritis? - Answer -The include widespread,
symmetrical joint swelling, erythemic joints which are warm to touch, loss of function in the joints,
morning stiffness that improves with movement, weight loss, weakness, and anorexia.
What are the clinical manifestations of Type I hypersensitivities? - Answer -(dependent on route
the allergen entered the body); include urticarial, rhinitis, conjunctivitis, and asthma
What blood type is considered a universal donor? - Answer -O negative
What blood type is considered a universal recipient? - Answer -AB positive
What do antibodies do in Type II hypersensitivities? - Answer -They react with the target cell's
receptors and prevent the cell from interacting with normal ligands, replaces the ligand, destroys the
receptor or inappropriately stimulates the receptor.
What do IgG and complement attract? - Answer -Neutrophils to the tissues
What do NK cells do in Type II hypersensitivities? - Answer -They recognize the target cell antigen
and release a toxic substance to destroy the target cell
What do the neutrophils do in Type II hypersensitivities? - Answer -Neutrophils perform
phagocytosis and release granules which cause tissue damage
What does alloimmunity imply? - Answer -Implies the formation of antibodies to foreign antigens
(exogenous antigens)
Hypersensitivities Latest Update Questions
with Correct Answers
A person with Type A blood has what antibodies? - Answer -B
A person with Type A blood has what antigen? - Answer -A antigen
A person with Type AB blood has what antibodies? - Answer -None
A person with Type AB blood has what antigens? - Answer -AB
A person with Type B blood has what antibodies? - Answer -A
A person with Type B blood has what antigen? - Answer -B antigen
A person with Type O blood has what antibodies? - Answer -AB
A person with Type O blood has what antigen? - Answer -None
How do we prevent Rh incompatibility reactions? - Answer -Administer Rh immune globulin
(Rhogam) within 72 hours of the initial birth
How is Type III hypersensitivity different from Type II hypersensitivity? - Answer -Type III is not
specific to a cell or tissue. The antigen antibody complexes are spread via circulation throughout the
body and generate a more diffuse reaction.
How is Type III hypersensitivity similar to Type II hypersensitivity? - Answer -They are both IgG and
IgM mediated responses.
How long do Type I hypersensitivity reactions occur after exposure to the allergen? - Answer -
Minutes to hours from time of exposure
How many types of hypersensitivities are there? - Answer -4 types; Types 1-4
What antigen does a person who is Rh negative have? - Answer -None
What antigen does a person who is Rh positive have? - Answer -Rh antigen
What are clinical manifestations of Systemic Lupus Erythematosus? - Answer -They include
butterfly rash (localized to cheeks), photosensitivity, nonerosive arthritis of at least 2 peripheral joints,
serositis, proteinuria, seizures, anemia, leukopenia, and thrombocytopenia. Symptoms and intensity may
vary, with no way of predicting either.
What are examples of Type IV hypersensitivity? - Answer -Contact dermatitis, reactive tuberculin
skin test, and solid organ transplant rejection
, What are most Type I hypersensitivity reactions attributed to? - Answer -Allergies to food,
medication, pollen, etc.
What are some autoimmune examples of Type II hypersensitivities? - Answer -Graves' disease,
Myasthenia Gravis, and Guillain-Barre' Syndrome
What are some examples of Type I hypersensitivities? - Answer -Environmental allergies, asthma
exacerbation, food allergies, drug allergies, animal allergies, and insect venom allergies
Angioedema which causes swelling of lips, eyes, and larynx. (Anaphylaxis is most severe reaction. Is
treated with epinephrine).
Atopic Disorders include hay fever, asthma, eczema, and urticarial. They have strong genetic disposition.
What are some examples of Type II hypersensitivities? - Answer -ABO incompatibilty and Rh
incompatibility
What are some examples of Type III hypersensitivities? - Answer -Systemic Lupus Erythematosus
and Rheumatoid Arthritis
What are the 4 blood types? - Answer -A, B, AB, O
What are the clinical manifestations of Rheumatoid Arthritis? - Answer -The include widespread,
symmetrical joint swelling, erythemic joints which are warm to touch, loss of function in the joints,
morning stiffness that improves with movement, weight loss, weakness, and anorexia.
What are the clinical manifestations of Type I hypersensitivities? - Answer -(dependent on route
the allergen entered the body); include urticarial, rhinitis, conjunctivitis, and asthma
What blood type is considered a universal donor? - Answer -O negative
What blood type is considered a universal recipient? - Answer -AB positive
What do antibodies do in Type II hypersensitivities? - Answer -They react with the target cell's
receptors and prevent the cell from interacting with normal ligands, replaces the ligand, destroys the
receptor or inappropriately stimulates the receptor.
What do IgG and complement attract? - Answer -Neutrophils to the tissues
What do NK cells do in Type II hypersensitivities? - Answer -They recognize the target cell antigen
and release a toxic substance to destroy the target cell
What do the neutrophils do in Type II hypersensitivities? - Answer -Neutrophils perform
phagocytosis and release granules which cause tissue damage
What does alloimmunity imply? - Answer -Implies the formation of antibodies to foreign antigens
(exogenous antigens)
