PHM Quizzes 1 and 2 Questions With Complete Solutions
An inhibitor of the enzyme dopamine-ß-hydroxylase will reduce
brain levels of which of the following neurotransmitters?
A) Dopamine
B) Norepinephrine
C) Serotonin
D) acetylcholine Correct Answers B) Norepinephrine
Drugs which inhibit acetylcholinesterase would enhance
neurotransmission in which of the following brain regions?
A) Septohippocampal neurons
B) ventral tegmental area neurons
C) Dorsal raphe neurons
D) Locus ceruleus neurons Correct Answers A)
Septohippocampal neurons
GTP-γ-S is a drug that irreversibly activates G-proteins. One
effect of treating neurons with this drug would be:
A) Increased levels of intracellular cyclic 3',5' AMP
B) Increased synthesis of norepinephrine
C) Increased microtubule trafficking of synaptic vesicle proteins
D) Upregulation of receptor Correct Answers A) Increased
levels of intracellular cyclic 3',5' AMP
Knockout of the gene that encodes the enzyme, monoamine
oxidase would result in enhanced neurotransmission at which
kind of synapse?
A) 5-HT synapses
B) Acetylcholine synapses
C) Glutamate synapses
, D) gamma-ammino-butyric acid (GABA) Correct Answers A)
5-HT synapses
Loss of sensitivity to the effects of drug due to changes in the
distribution or metabolism of that drug is called:
Learned tolerance
Cross tolerance
Pharmacokinetic tolerance
Pharmacodynamic tolerance Correct Answers Pharmokinetic
Tolerance
Many factors contribute to drug addiction and continued drug
use. Which of the following is not one of these factors?
A) 1st order elimination kinetics
B) Drug tolerance
C) Drug dependence
D) Drug withdrawal Correct Answers A) 1st order elimination
kinetics
One consequence of "knockout" or deletion of the gene that
encodes the enzyme phenylethanolamine-N-methyl-transferase
would be:
- Depletion of dopamine stores in nerve terminals in the nucleus
accumbens
- Depletion of the norepinephrine content in the locus ceruleus
- Depletion of epinephrine from the adrenal medulla
- Depletion of acetylcholine from the nucleus basalis Correct
Answers - Depletion of epinephrine from the adrenal medulla
An inhibitor of the enzyme dopamine-ß-hydroxylase will reduce
brain levels of which of the following neurotransmitters?
A) Dopamine
B) Norepinephrine
C) Serotonin
D) acetylcholine Correct Answers B) Norepinephrine
Drugs which inhibit acetylcholinesterase would enhance
neurotransmission in which of the following brain regions?
A) Septohippocampal neurons
B) ventral tegmental area neurons
C) Dorsal raphe neurons
D) Locus ceruleus neurons Correct Answers A)
Septohippocampal neurons
GTP-γ-S is a drug that irreversibly activates G-proteins. One
effect of treating neurons with this drug would be:
A) Increased levels of intracellular cyclic 3',5' AMP
B) Increased synthesis of norepinephrine
C) Increased microtubule trafficking of synaptic vesicle proteins
D) Upregulation of receptor Correct Answers A) Increased
levels of intracellular cyclic 3',5' AMP
Knockout of the gene that encodes the enzyme, monoamine
oxidase would result in enhanced neurotransmission at which
kind of synapse?
A) 5-HT synapses
B) Acetylcholine synapses
C) Glutamate synapses
, D) gamma-ammino-butyric acid (GABA) Correct Answers A)
5-HT synapses
Loss of sensitivity to the effects of drug due to changes in the
distribution or metabolism of that drug is called:
Learned tolerance
Cross tolerance
Pharmacokinetic tolerance
Pharmacodynamic tolerance Correct Answers Pharmokinetic
Tolerance
Many factors contribute to drug addiction and continued drug
use. Which of the following is not one of these factors?
A) 1st order elimination kinetics
B) Drug tolerance
C) Drug dependence
D) Drug withdrawal Correct Answers A) 1st order elimination
kinetics
One consequence of "knockout" or deletion of the gene that
encodes the enzyme phenylethanolamine-N-methyl-transferase
would be:
- Depletion of dopamine stores in nerve terminals in the nucleus
accumbens
- Depletion of the norepinephrine content in the locus ceruleus
- Depletion of epinephrine from the adrenal medulla
- Depletion of acetylcholine from the nucleus basalis Correct
Answers - Depletion of epinephrine from the adrenal medulla
