Test bank for Janeways Immunobiology 9th Edition by
Kenneth Murphy; Casey Weaver | 9780815345053 | Chapter
1-16 | All Chapters with Answers and Rationals
Lectin - ANSWER: Carbohydrate-binding antimicrobial peptide. Includes RegIIIgamma and human
RegIIIalpha
Humoral fluid - ANSWER: Complement and other defensive proteins circulating in bodily fluid
5 categories of disease-causing agents - ANSWER: Bacteria, virus, fungi, helminth, protozoa
Composition of Gram positive bacterial cell wall - ANSWER: Peptidoglycan, Lipoteichoic acid, Teichoic
acid.
Composition of Gram negative bacterial cell wall - ANSWER: Smaller peptidoglycan, Lipoprotein,
Lipopolysaccharide
Zoonotic Infection - ANSWER: Disease originally endemic in non-human animals.
Cystic Fibrosis - ANSWER: Loss of function of epithelial chloride channel, causing dehydrated mucus.
Bacterial colonies typically form as epithelial cilia fail to move mucus out of body.
Function of lysozyme - ANSWER: Cleaves carbohydrate bonds in peptidoglycan layer of bacterial cell
walls.
Where are lysozyme and secretory phospholipase A2 found? - ANSWER: Tears, saliva, paneth cells of
small intestine.
Secretory phospholipase A2 - ANSWER: Basic enzyme that can enter bacterial cell wall to hydrolyze
phospholipids in plasma membrane.
Defensin structure - ANSWER: Amphipathic polypeptide.
Function of defensin proteins - ANSWER: Insert into hydrophobic region of membrane bilayer,
forming a pore upon contact with other inserted defensins.
Paneth cell locatied - ANSWER: Small intestinal crypts
Zymogen - ANSWER: Inactive enzyme precursor requiring hydrolysis of pro-region
Neutrophil primary granules - ANSWER: Lysosome-like vesicle containing antimicrobial agents.
Induced to fuse with phagosome. Contains neutrophil elastase
Neutrophil secondary granules - ANSWER: Store propeptide cathelicidins; activated upon fusion
w/primary granule.
Cathelicidins - ANSWER: Antimicrobial protein produced by neutrophil and macrophages, secreted by
keratinocytes and epithelia of lung and intestine.
Histatins - ANSWER: Produced in parotid, sublingual and submandibular glands. Are antifungal
peptides that promote rapid wound healing.
Complement proteins are produced mostly in the ________________ - ANSWER: Liver
, 3 pathways of complement activation - ANSWER: Classical, alternative, lectin
Binds to antigen:antibody complex and pathogenic surface - ANSWER: C1q
binds to carbohydrate structures (ex. mannose) - ANSWER: MBL/Ficolins
Properdin (factor P)
Activating enzymes - ANSWER: C1r
C1s
C2a
Bb
D
MASP-1, 2, 3
Surface-binding proteins and opsonins - ANSWER: C3b
C4b
Inflammatory mediators - ANSWER: C3a
C4a
C5a
Membrane-attack proteins - ANSWER: C5b
C6
C7
C8
C9
Complement receptors - ANSWER: CR1
CR2
CR3
CR4
CRIg
C3 convertase of lectin pathway - ANSWER: C4b2a
C3 convertase of classical pathway - ANSWER: C4b2a
C3 convertase of alternative pathway - ANSWER: C3bBb
Fluid phase C3 convertase - ANSWER: C3(H2O)Bb
Protein that stabilizes alternative and fluid phase convertase - ANSWER: Properdin (Factor P)
Surfactant protein SP-A and SP-D - ANSWER: Secreted in lung epithelia. Opsonize pathogens, but do
not interact with MASP and so do not activate complement
The pathogen sensor of the classical pathway - ANSWER: C1 complex
C1 activated by - ANSWER: Surface-bound antibody, direct pathogen surface.
C1 pathogen sensor subunit - ANSWER: C1q
C1 serine protease subunits - ANSWER: C1r and C1s (initially inactive)
Proteoglycan - ANSWER: Component of animal ECM in connective tissue
Peptidoglycan - ANSWER: Component of bacterial cell wall
Kenneth Murphy; Casey Weaver | 9780815345053 | Chapter
1-16 | All Chapters with Answers and Rationals
Lectin - ANSWER: Carbohydrate-binding antimicrobial peptide. Includes RegIIIgamma and human
RegIIIalpha
Humoral fluid - ANSWER: Complement and other defensive proteins circulating in bodily fluid
5 categories of disease-causing agents - ANSWER: Bacteria, virus, fungi, helminth, protozoa
Composition of Gram positive bacterial cell wall - ANSWER: Peptidoglycan, Lipoteichoic acid, Teichoic
acid.
Composition of Gram negative bacterial cell wall - ANSWER: Smaller peptidoglycan, Lipoprotein,
Lipopolysaccharide
Zoonotic Infection - ANSWER: Disease originally endemic in non-human animals.
Cystic Fibrosis - ANSWER: Loss of function of epithelial chloride channel, causing dehydrated mucus.
Bacterial colonies typically form as epithelial cilia fail to move mucus out of body.
Function of lysozyme - ANSWER: Cleaves carbohydrate bonds in peptidoglycan layer of bacterial cell
walls.
Where are lysozyme and secretory phospholipase A2 found? - ANSWER: Tears, saliva, paneth cells of
small intestine.
Secretory phospholipase A2 - ANSWER: Basic enzyme that can enter bacterial cell wall to hydrolyze
phospholipids in plasma membrane.
Defensin structure - ANSWER: Amphipathic polypeptide.
Function of defensin proteins - ANSWER: Insert into hydrophobic region of membrane bilayer,
forming a pore upon contact with other inserted defensins.
Paneth cell locatied - ANSWER: Small intestinal crypts
Zymogen - ANSWER: Inactive enzyme precursor requiring hydrolysis of pro-region
Neutrophil primary granules - ANSWER: Lysosome-like vesicle containing antimicrobial agents.
Induced to fuse with phagosome. Contains neutrophil elastase
Neutrophil secondary granules - ANSWER: Store propeptide cathelicidins; activated upon fusion
w/primary granule.
Cathelicidins - ANSWER: Antimicrobial protein produced by neutrophil and macrophages, secreted by
keratinocytes and epithelia of lung and intestine.
Histatins - ANSWER: Produced in parotid, sublingual and submandibular glands. Are antifungal
peptides that promote rapid wound healing.
Complement proteins are produced mostly in the ________________ - ANSWER: Liver
, 3 pathways of complement activation - ANSWER: Classical, alternative, lectin
Binds to antigen:antibody complex and pathogenic surface - ANSWER: C1q
binds to carbohydrate structures (ex. mannose) - ANSWER: MBL/Ficolins
Properdin (factor P)
Activating enzymes - ANSWER: C1r
C1s
C2a
Bb
D
MASP-1, 2, 3
Surface-binding proteins and opsonins - ANSWER: C3b
C4b
Inflammatory mediators - ANSWER: C3a
C4a
C5a
Membrane-attack proteins - ANSWER: C5b
C6
C7
C8
C9
Complement receptors - ANSWER: CR1
CR2
CR3
CR4
CRIg
C3 convertase of lectin pathway - ANSWER: C4b2a
C3 convertase of classical pathway - ANSWER: C4b2a
C3 convertase of alternative pathway - ANSWER: C3bBb
Fluid phase C3 convertase - ANSWER: C3(H2O)Bb
Protein that stabilizes alternative and fluid phase convertase - ANSWER: Properdin (Factor P)
Surfactant protein SP-A and SP-D - ANSWER: Secreted in lung epithelia. Opsonize pathogens, but do
not interact with MASP and so do not activate complement
The pathogen sensor of the classical pathway - ANSWER: C1 complex
C1 activated by - ANSWER: Surface-bound antibody, direct pathogen surface.
C1 pathogen sensor subunit - ANSWER: C1q
C1 serine protease subunits - ANSWER: C1r and C1s (initially inactive)
Proteoglycan - ANSWER: Component of animal ECM in connective tissue
Peptidoglycan - ANSWER: Component of bacterial cell wall
