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  • University Of Sri Jayewardenepura
  • Med (PHARMACOLOGY)
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Class notes

Pain relief with paracetamol and NSAIDs

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4 pages
2023/2024 Written for academic year
Institution
University Of Sri Jayewardenepura
Course
Med (PHARMACOLOGY)
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This document was made based on the lecture on pain relief.Although there are many pain reliving drugs. this contain comprehensive summery of above drugs with relevant indications and contraindications,side effects etc.Special attention has been paid to made note as short as possible at the same time to make it very informative.I used it in almost all my exams and got good results.Hope it will help you too.

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Paracetamol and NSAIDS
Has antipyretic action


Inhibits enzyme cyclooxygenase No significant anti- In Rheumatoid Arthritis
Effects
that catalyses synthesis of inflammatory effect. PCM alone not enough
Mechanism of prostaglandins and thromboxane +add NSAIDs
action from arachidonic acid
mild analgesic


No effect on platelet function, or clotting factors


Orally well absorbed
not uricosuric.


Pharmacokinetics Absorption does not cause gastric irritation.



Conjugation with glucuronic acid Non
Metabolism -



Paracetamol
toxic
Paracetamol
Glutathione metabolite
(acetaminophen) P450 NABQI
About
Toxic intermediate
5%-10%
metabolite

Toxic
In an overdose, the capacity for Once glutathione
metabolites
conjugation is exceeded with a higher stores are
accumulate
amount undergoing oxidation forming an depleted
,liver
excessive amount of NABQI damage

Excretion - urine


- 4 g daily for an adult Given 4-6 hrly
Dosage Maximum daily
dose 60 mg/kg for a child. In children given
weight based doses

ØChronic alcoholics
Caution ØChronic malnutrition
ØHepatic impairment

Document information

Uploaded on
August 17, 2024
Number of pages
4
Written in
2023/2024
Type
Class notes
Professor(s)
Nilangika sandakumari
Contains
Pharmacology of pain relief
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Subjects

  • nsaids
  • paracetamol
  • pharmacology
  • 2023
  • 2024
  • revision
  • spaced repetition
  • easy revision
  • mcq
  • seq
  • mind mapping

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