Test Bank for Basic and Clinical Pharmacology, 14th Edition by
Bertram G. Katzung, 9781259641152, Covering Chapters 1-66
| Includes Rationales
Pharmacology - ANSWER: study of f the history, source, physical and chemical properties,
compounding, biochemical and physiological effect, mechanisms of action, absorption, distribution,
biotransformation and excretion, and therapeutic and other uses of drugs
Drug - ANSWER: any chemical agent that when taken into a living organism may modify one or more
of its functions
Toxicology - ANSWER: study of poisonous substances and their effects upon body parts
Pharmacokinetics - ANSWER: where drugs go, how long they stay, what chemical changes occur, how
they are removed; effect of body on a drug
Absorption - ANSWER: the movement of a drug from the site of administration to bloodstream; intake
of a drug into the system
Distribution - ANSWER: the transfer of a drug from one location to another within the body; where
the drug goes following absorption
Elimination - ANSWER: the removal of materials from the body; removal of a drug
Pharmacodynamics - ANSWER: what the drug does to the body; mechanism of action
systemic effects - ANSWER: generalized distribution of the chemical throughout the body by the
bloodstream to internal organs
Effect - ANSWER: the change in the organism caused by the chemical
Law of Mass Action - ANSWER: the rate of a chemical reaction is proportional to the product of the
activities or concentrations of the reactants
Response - ANSWER: is a function of the drug-receptor complex
ED50 - ANSWER: median effective dose; therapeutic effect; the dose required to achieve 50% of
desired response in 50% of the population
TD50 - ANSWER: median toxic dose; toxic effect; the dose required to get 50% of population reporting
this specific toxic effect
LD50 - ANSWER: median lethal dose; lethal effect; dose required to achieve 50% mortality from
toxicity
EC50 - ANSWER: half maximum effective concentration; concentration of a drug at which 50% of its
maximum response is observed
LC50 - ANSWER: half lethal concentration; concentration of a drug at which 50% mortality
Quantal dose response curve - ANSWER: A graph of the fraction of a population that shows a specified
response at progressively increasing doses
Bertram G. Katzung, 9781259641152, Covering Chapters 1-66
| Includes Rationales
Pharmacology - ANSWER: study of f the history, source, physical and chemical properties,
compounding, biochemical and physiological effect, mechanisms of action, absorption, distribution,
biotransformation and excretion, and therapeutic and other uses of drugs
Drug - ANSWER: any chemical agent that when taken into a living organism may modify one or more
of its functions
Toxicology - ANSWER: study of poisonous substances and their effects upon body parts
Pharmacokinetics - ANSWER: where drugs go, how long they stay, what chemical changes occur, how
they are removed; effect of body on a drug
Absorption - ANSWER: the movement of a drug from the site of administration to bloodstream; intake
of a drug into the system
Distribution - ANSWER: the transfer of a drug from one location to another within the body; where
the drug goes following absorption
Elimination - ANSWER: the removal of materials from the body; removal of a drug
Pharmacodynamics - ANSWER: what the drug does to the body; mechanism of action
systemic effects - ANSWER: generalized distribution of the chemical throughout the body by the
bloodstream to internal organs
Effect - ANSWER: the change in the organism caused by the chemical
Law of Mass Action - ANSWER: the rate of a chemical reaction is proportional to the product of the
activities or concentrations of the reactants
Response - ANSWER: is a function of the drug-receptor complex
ED50 - ANSWER: median effective dose; therapeutic effect; the dose required to achieve 50% of
desired response in 50% of the population
TD50 - ANSWER: median toxic dose; toxic effect; the dose required to get 50% of population reporting
this specific toxic effect
LD50 - ANSWER: median lethal dose; lethal effect; dose required to achieve 50% mortality from
toxicity
EC50 - ANSWER: half maximum effective concentration; concentration of a drug at which 50% of its
maximum response is observed
LC50 - ANSWER: half lethal concentration; concentration of a drug at which 50% mortality
Quantal dose response curve - ANSWER: A graph of the fraction of a population that shows a specified
response at progressively increasing doses
