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GMS 6530/GMS6530 University Of Florida -GMS 6530 Coagulation Questions With Complete Solutions

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GMS 6530/GMS6530 University Of Florida -GMS 6530 Coagulation Questions With Complete Solutions

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GMS 6530 Coagulation Questions With Complete Solutions

Haemostasis Correct Answers 1) vasoconstriction ...... ......




2) platelet phase - plug formation
3) plasmatic phase - fibrin clot formation
4) fibrinolytic phase - plasmin degradation of fibrin

Platelet aggregation Correct Answers - tissue damage (exposed
...... ......




collagen) > platelet recruitment to collage (via vWF) > platelet
degranulation (activation) > ADP + 5-HT + TxA2 >
GPIIv/LLLa receptor activation > platelet aggration

Thrombin Correct Answers - last enzyme in common pathway
...... ......




- converts soluble fibrinogen to insoluble fibrin mesh trapping
blood cells and forming clot

Vitamin K depenent factors Correct Answers - II ...... ......




- VII
- IX
-X

tPA Correct Answers - tissue plasminogen activtor
...... ......




- activates plasminogen to plasmin

Plasmin Correct Answers - chops up fibrin and fibrinogen
...... .... ..




aPTT Correct Answers - activated partial thromboplastin time
...... ......




- measure of intrinsic pathway
- norm. 25-35 sec

PT Correct Answers - prothrombin time
...... ......

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