Parathyroid Pharmacology Questions And Answers Study Guide With Complete Solution!!

PARATHYROID PHARMACOLOGY QUESTIONS AND ANSWERS
STUDY GUIDE WITH COMPLETE SOLUTION!!
Where is PTH made and secreted?
Answers :Chief Cells in parathyroid gland
what stimulates PTH synthesis and secretion?


Answers :low plasma Ca2+


and high plasma phosphorus
Where does PTH bind?


Answers :Plasma membrane PTH receptors (GPCRs) in kidney and bone
What does PTH do in the kidney?


Answers :Increase reabsorption of Ca2+


decrease reabsorption of phosphate


stimulate 1-hydroxylation of vitamin D to form active 1,25-dihydroxyvitamin D
Net effect of PTH on kidney


Answers :Increase plasma Ca2, decrease plasma phosphate
Effect of PTH in bone

, Answers :Acts directly on osteoblast and osteoclast precurosrs to stimulate
cytokines that increase production and activiy of osteoclasts ( M-CSF and RANK
ligand)


leads to increased bone remodeling
Continuous PTH stimulation


Answers :favors bone resorption= increase plasma ca2+
Pulsatile PTH


Answers :favors bone formation


maybe increase osteoblast number via increased production and decreased
osteoblast apoptosis
two forms of vitamin D


Answers :Vitamin D2 (ergocalciferol)


Vitamin D3 (Cholecalciferol)


biologicaly equivalent


undergo 2 step hydroxylation to form active 1,25-dihydroxyvitamin D, first in liver
(25-hydroxylation), then in kidney (1-hydroxylation)
where is vitamin D2 obtained?


Answers :diet