Antimicrobial Drug Characteristics
Activation of membrane proteins pumping drugs out of cells - ✔✔Activation of drug pumps
Alteration of target site preventing drug efficacy - ✔✔Change in drug binding site
Altered drug transport receptor preventing drug entry - ✔✔Decreased permeability
Analog of cytosine, treats cutaneous and systemic mycoses - ✔✔Flucytosine
Antimalarial drug - ✔✔Chloroquine
Antimalarial drug - ✔✔Mefloquine
Antimalarial drug - ✔✔Primaquine
Antimalarial drug - ✔✔Quinine
Antimicrobial compounds synthesized entirely in the lab - ✔✔Synthetic Drugs
Attach to ribosomal 50s subunit, low toxicity, broad-spectrum - ✔✔Macrolides
Balanced for satisfactory compromise in effectiveness - ✔✔Antimicrobial Drug Characteristics
Bind to DNA gyrase and topoisomerase IV, broad-spectrum - ✔✔Fluoroquinolones
Bind to fungal membranes, disrupt selective permeability - ✔✔Macrolide polyenes
Block protein synthesis by binding ribosomes, broad-spectrum - ✔✔Tetracycline Antibiotics
Blocks mRNA-ribosome interaction, treats MRSA and VRE - ✔✔Oxazolidinones
Blocks peptide bond formation, synthesized chemically - ✔✔Chloramphenicol
Broad-spectrum antibiotics, resistant to penicillinases - ✔✔Cephalosporins
Broad-spectrum antifungals like ketoconazole, clotrimazole - ✔✔Synthetic azoles
Broad-spectrum drug for aerobic and anaerobic infections - ✔✔Carbapenems
Activation of membrane proteins pumping drugs out of cells - ✔✔Activation of drug pumps
Alteration of target site preventing drug efficacy - ✔✔Change in drug binding site
Altered drug transport receptor preventing drug entry - ✔✔Decreased permeability
Analog of cytosine, treats cutaneous and systemic mycoses - ✔✔Flucytosine
Antimalarial drug - ✔✔Chloroquine
Antimalarial drug - ✔✔Mefloquine
Antimalarial drug - ✔✔Primaquine
Antimalarial drug - ✔✔Quinine
Antimicrobial compounds synthesized entirely in the lab - ✔✔Synthetic Drugs
Attach to ribosomal 50s subunit, low toxicity, broad-spectrum - ✔✔Macrolides
Balanced for satisfactory compromise in effectiveness - ✔✔Antimicrobial Drug Characteristics
Bind to DNA gyrase and topoisomerase IV, broad-spectrum - ✔✔Fluoroquinolones
Bind to fungal membranes, disrupt selective permeability - ✔✔Macrolide polyenes
Block protein synthesis by binding ribosomes, broad-spectrum - ✔✔Tetracycline Antibiotics
Blocks mRNA-ribosome interaction, treats MRSA and VRE - ✔✔Oxazolidinones
Blocks peptide bond formation, synthesized chemically - ✔✔Chloramphenicol
Broad-spectrum antibiotics, resistant to penicillinases - ✔✔Cephalosporins
Broad-spectrum antifungals like ketoconazole, clotrimazole - ✔✔Synthetic azoles
Broad-spectrum drug for aerobic and anaerobic infections - ✔✔Carbapenems
