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Antimicrobial Drug Characteristics
Activation of membrane proteins pumping drugs out of cells - ✔✔Activation of drug pumps

Alteration of target site preventing drug efficacy - ✔✔Change in drug binding site

Altered drug transport receptor preventing drug entry - ✔✔Decreased permeability

Analog of cytosine, treats cutaneous and systemic mycoses - ✔✔Flucytosine

Antimalarial drug - ✔✔Chloroquine

Antimalarial drug - ✔✔Mefloquine

Antimalarial drug - ✔✔Primaquine

Antimalarial drug - ✔✔Quinine

Antimicrobial compounds synthesized entirely in the lab - ✔✔Synthetic Drugs

Attach to ribosomal 50s subunit, low toxicity, broad-spectrum - ✔✔Macrolides

Balanced for satisfactory compromise in effectiveness - ✔✔Antimicrobial Drug Characteristics

Bind to DNA gyrase and topoisomerase IV, broad-spectrum - ✔✔Fluoroquinolones

Bind to fungal membranes, disrupt selective permeability - ✔✔Macrolide polyenes

Block protein synthesis by binding ribosomes, broad-spectrum - ✔✔Tetracycline Antibiotics

Blocks mRNA-ribosome interaction, treats MRSA and VRE - ✔✔Oxazolidinones

Blocks peptide bond formation, synthesized chemically - ✔✔Chloramphenicol

Broad-spectrum antibiotics, resistant to penicillinases - ✔✔Cephalosporins

Broad-spectrum antifungals like ketoconazole, clotrimazole - ✔✔Synthetic azoles

Broad-spectrum drug for aerobic and anaerobic infections - ✔✔Carbapenems

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Eric M. Scholar Associate Professor of Pharmacology University of Nebraska College of Medicine, William B. Pratt Professor of Pharmacology University of Michigan Medical School The Antimicrobial Drugs
Publisher: 2000 ISBN: 9780199759712 Edition: Unknown

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