ABSITE Review UPDATED Exam
Questions and CORRECT Answers
Initial treatment of 50 year-old female with metastatic breast CA to ribs & spine with ↑Ca²⁺ -
CORRECT ANSWER- Bisphosphonates
[Fluid + Lasix + mithramycine/bisphos/calcitonin/ aldaronic acid]
Contraindications to SLNBx - CORRECT ANSWER- 1. Clinically suspicious axillary LN
2. T3/T4
3. Large biopsy cavity
4. Prior axillary surgery
5. Recent mammoplasty/breast implant
6. Likely intraductal papilloma
Young woman with bloody nipple discharge & normal mammogram → - CORRECT
ANSWER- Likely intraductal papilloma → ductal excision
Treatment of breast pain - CORRECT ANSWER- Bromocriptine (inhibits prolactin secretion)
Which is a contraindication to segmental mastectomy or BCT, multicentric disease or
pectoralis involvement? - CORRECT ANSWER- Multicentric disease
ER is a marker for _____ - CORRECT ANSWER- Tumor differentiation
LCIS @ margin of breast excision, NEXT STEP - CORRECT ANSWER- No further Rx
Tamoxifen & close follow-up
Management of phyllodes tumor (2 cm) - CORRECT ANSWER- WLE without nodal
dissection
, Management of post-menopausal, ER+, T1N1 (stage IIa) breast CA - CORRECT ANSWER-
Chemotherapy + Tamoxifen
Management of melanoma <0.75mm - CORRECT ANSWER- WLE with 1-cm margins
Management of 1.2mm superficial melanoma without palpable node(s) - CORRECT
ANSWER- WLE with 2-cm margins + SLNBx for all lesions >1.0mm
Management of anal SCCa - CORRECT ANSWER- ChemoXRT (Nigro protocol)
Malignancy most likely to have ascites and carinomatosis - CORRECT ANSWER- Ovarian
Cancer-related cachexia is related to ____ - CORRECT ANSWER- TNFα
Cancer least likely to metastasize to bone - CORRECT ANSWER- Prostate > Breast > Lung
> Kidney > THYROID
Inguinal LN biopsy positive for melanoma with no identifiable primary ... NEXT STEP -
CORRECT ANSWER- CT abdomen/pelvis
Inhibitory factor of tumor growth - CORRECT ANSWER- TGFβ
Mechanism of angiogenesis - CORRECT ANSWER- Proliferation/migration
Management of 0.8mm melanoma - CORRECT ANSWER- WLE with 1-cm margins
Which is a more specific tumor marker, β-hCG vs. CA-125? - CORRECT ANSWER- β-hCG
Radiation insensitivity in large tumors are 2° to _____ - CORRECT ANSWER- Hypoxia
Submucosal spread of tumor is most common in ______ CA - CORRECT ANSWER-
Esophageal
Questions and CORRECT Answers
Initial treatment of 50 year-old female with metastatic breast CA to ribs & spine with ↑Ca²⁺ -
CORRECT ANSWER- Bisphosphonates
[Fluid + Lasix + mithramycine/bisphos/calcitonin/ aldaronic acid]
Contraindications to SLNBx - CORRECT ANSWER- 1. Clinically suspicious axillary LN
2. T3/T4
3. Large biopsy cavity
4. Prior axillary surgery
5. Recent mammoplasty/breast implant
6. Likely intraductal papilloma
Young woman with bloody nipple discharge & normal mammogram → - CORRECT
ANSWER- Likely intraductal papilloma → ductal excision
Treatment of breast pain - CORRECT ANSWER- Bromocriptine (inhibits prolactin secretion)
Which is a contraindication to segmental mastectomy or BCT, multicentric disease or
pectoralis involvement? - CORRECT ANSWER- Multicentric disease
ER is a marker for _____ - CORRECT ANSWER- Tumor differentiation
LCIS @ margin of breast excision, NEXT STEP - CORRECT ANSWER- No further Rx
Tamoxifen & close follow-up
Management of phyllodes tumor (2 cm) - CORRECT ANSWER- WLE without nodal
dissection
, Management of post-menopausal, ER+, T1N1 (stage IIa) breast CA - CORRECT ANSWER-
Chemotherapy + Tamoxifen
Management of melanoma <0.75mm - CORRECT ANSWER- WLE with 1-cm margins
Management of 1.2mm superficial melanoma without palpable node(s) - CORRECT
ANSWER- WLE with 2-cm margins + SLNBx for all lesions >1.0mm
Management of anal SCCa - CORRECT ANSWER- ChemoXRT (Nigro protocol)
Malignancy most likely to have ascites and carinomatosis - CORRECT ANSWER- Ovarian
Cancer-related cachexia is related to ____ - CORRECT ANSWER- TNFα
Cancer least likely to metastasize to bone - CORRECT ANSWER- Prostate > Breast > Lung
> Kidney > THYROID
Inguinal LN biopsy positive for melanoma with no identifiable primary ... NEXT STEP -
CORRECT ANSWER- CT abdomen/pelvis
Inhibitory factor of tumor growth - CORRECT ANSWER- TGFβ
Mechanism of angiogenesis - CORRECT ANSWER- Proliferation/migration
Management of 0.8mm melanoma - CORRECT ANSWER- WLE with 1-cm margins
Which is a more specific tumor marker, β-hCG vs. CA-125? - CORRECT ANSWER- β-hCG
Radiation insensitivity in large tumors are 2° to _____ - CORRECT ANSWER- Hypoxia
Submucosal spread of tumor is most common in ______ CA - CORRECT ANSWER-
Esophageal
