Module Quizzes NUR3196 Questions and Answers

The patient requires a drug that is known to be completely metabolized by the first-pass effect. What change will be needed when this drug is administered? - The drug must be given more frequently - The drug must be given in higher doses. - The drug must be given in a lipid-soluble form. - The drug must be given by a non-oral route, such as parenterally. Answer The drug must be given by a non-oral route, such as parenterally. Rationale: Some oral drugs are rendered inactive by hepatic metabolic reactions, during the process known as the first-pass effect. An alternative route, such as parenteral, may need to be used. A patient who has acute kidney injury (AKI) may have a diminished capacity to excrete medications. The nurse must assess the patient more frequently for what development? - Increased risk of allergy - Decreased therapeutic drug effects - Increased risk for drug toxicity - Increased absorption of the drug from the intestines Answer Increased risk for drug toxicity Rationale: The kidneys are the primary site of excretion. Renal failure increases the duration of the drug's action because of decreased excretion. The patient must be assessed for drug toxicity. What is the rationale for the administration of a loading dose of a drug? - It decreases the number of doses that must be given. - It results in lower dosages being required to achieve therapeutic effects. - It decreases the risk of drug toxicity. - It more rapidly builds pla