Musculoskeletal -nsaid High-Scoring Q&A, Thoroughly Verified and Tested

arachidonic acid derivatives - Answer prostaglandins, thromboxanes, & prostacyclin (all via cyclooxygenase), leukotrienes (via lipoxygenase) LTB4 function - Answer neutrophil chemotaxis ("neutrophils arrive B4 others") LTC4, LTD4, LTE4 functions - Answer SM contraction (BRONCHOCONSTRICTION, vasoconstriction) & vascular permeability PGI2 function - Answer inhibits platelet aggregation & promotes vasodilation corticosteroids inhibit - Answer phospholipase A2 (decreased AA) (blocks liberation of arachidonic acid from membrane phosphatidylinositol). Indirectly inhi cox2 by inhi nfKb by upregul iKb acetaminophen mechanism - Answer reversibly inhibits COX primarily in CNS (inactivated peripherally) → antipyretic & analgesic, but not anti-inflammatory acetaminophen toxicity (overdose) - Answer HEPATIC NECROSIS via metabolite NAPQI depletes glutathione → toxic byproducts Renal papillary necrosis acetaminophen antidote - Answer N-acetylcysteine aspirin irreversibly inhibits COX1 (& COX2) via _______ (reaction type) - Answer acetylation aspirin uses: low, intermediate, high - Answer low: inhibit platelet aggegation intermediate: antipyretic, analgesic high: anti-inflammatory aspirin toxicity..........