APHON OVERVIEW EXAM | QUESTIONS
& ANSWERS (VERIFIED) | LATEST
UPDATE | GRADED A+
biotherapy
Correct Answer: modality of tx: agents that resemble body's own defense and
surveillance systems. can augment/modulate/restore host's immune response, direct
antitumor activity, other biological effects. side effects typically hypersensitivity rx
immune surveillance
Correct Answer: tumor cells express abnormal tumor antigens on surface that can
be recognized/destroyed by immune system
natural killer cells
Correct Answer: lymphocyte that recognizes/kills malignant cells
cytotoxic t cells
Correct Answer: recognize tumor-assosiated antigens and kills cells
interferons
Correct Answer: multiple moa's & produced w/ recombinant dna.
1
,protein capable of protecting other cells from viral infections by interfering w/ viral
replication.
family of glycoproteins include: antiviral, antiproliferative, potent immunomodulatory
effects
cytokines
Correct Answer: products of immune cells to enhance cytotoxic activity of cells and
increase immune response
alpha-interferon
Correct Answer: leukocyte-derived. tx: hairy cell leukemia, melanoma, chronic
myeloid leukemia, follicular lymphoma, multiple myeloma, cutaneous t-cell lymphoma
beta-interferon
Correct Answer: fibroblast-derived. tx MS
gamma-interferon
Correct Answer: t-lymphocyte derived. tx chronic granulomatus disease
interleukin-2
Correct Answer: produced by t-helper cells & stimulate growth/maturation of t-cell
subsets, cytotoxic t-cells, production of lymphokines & cytokines.
act as chemical signals b/w wbc's (revs up immune system)
2
,retinoids
Correct Answer: immunomodulators that facilitate differentiation & suppress
proliferation of cancer cells
all-trans retinoic acid (atra)
Correct Answer: tx: aml, aml m3 subtype, apl
increase maturation of promyelocytic blasts and rapid resolution of coagulopathy r/t tx.
isotretinoin (accutane)
Correct Answer: retinoid tx neuroblastoma.
have antitumor activity unknown moa. TERATOGENIC. male/female pt must register
iPledge (fetal exposure). can also affect hearing & vision
antibodies
Correct Answer: proteins produced by b-lymphocytes. part of humoral immunity of
adaptive system. includes immunoglobulins (igG, igA, igM, igE, igD)
murine
Correct Answer: mouse-derived MoAbs. pt develops human antimouse antibodies
creating high risk of hypersensitivity rx
end in -momab
3
, Monoclonal antibodies
Correct Answer: very specific. directed against single antigenic determinant on cell
surface causing antibody-dependent cellular toxicity, direct cell death, elimination of
antigen/target cell that expresses the antigen
low toxicity
-ximab
Correct Answer: moab combo of human & mouse antibodies
-zumab
Correct Answer: moab humanized, small part of mouse antibody fused w/ human
antibody
-umab
Correct Answer: fully humanized moabs
chimeric moab
Correct Answer: murine variable & human constant coupled using recombinant dna
purpose of moabs
Correct Answer: attach low-dose radioisotopes to image residual disease. target
chemo, radiation, biotherapy to tumor
purge autologous bone marrow of cancer cells before transplant
4
& ANSWERS (VERIFIED) | LATEST
UPDATE | GRADED A+
biotherapy
Correct Answer: modality of tx: agents that resemble body's own defense and
surveillance systems. can augment/modulate/restore host's immune response, direct
antitumor activity, other biological effects. side effects typically hypersensitivity rx
immune surveillance
Correct Answer: tumor cells express abnormal tumor antigens on surface that can
be recognized/destroyed by immune system
natural killer cells
Correct Answer: lymphocyte that recognizes/kills malignant cells
cytotoxic t cells
Correct Answer: recognize tumor-assosiated antigens and kills cells
interferons
Correct Answer: multiple moa's & produced w/ recombinant dna.
1
,protein capable of protecting other cells from viral infections by interfering w/ viral
replication.
family of glycoproteins include: antiviral, antiproliferative, potent immunomodulatory
effects
cytokines
Correct Answer: products of immune cells to enhance cytotoxic activity of cells and
increase immune response
alpha-interferon
Correct Answer: leukocyte-derived. tx: hairy cell leukemia, melanoma, chronic
myeloid leukemia, follicular lymphoma, multiple myeloma, cutaneous t-cell lymphoma
beta-interferon
Correct Answer: fibroblast-derived. tx MS
gamma-interferon
Correct Answer: t-lymphocyte derived. tx chronic granulomatus disease
interleukin-2
Correct Answer: produced by t-helper cells & stimulate growth/maturation of t-cell
subsets, cytotoxic t-cells, production of lymphokines & cytokines.
act as chemical signals b/w wbc's (revs up immune system)
2
,retinoids
Correct Answer: immunomodulators that facilitate differentiation & suppress
proliferation of cancer cells
all-trans retinoic acid (atra)
Correct Answer: tx: aml, aml m3 subtype, apl
increase maturation of promyelocytic blasts and rapid resolution of coagulopathy r/t tx.
isotretinoin (accutane)
Correct Answer: retinoid tx neuroblastoma.
have antitumor activity unknown moa. TERATOGENIC. male/female pt must register
iPledge (fetal exposure). can also affect hearing & vision
antibodies
Correct Answer: proteins produced by b-lymphocytes. part of humoral immunity of
adaptive system. includes immunoglobulins (igG, igA, igM, igE, igD)
murine
Correct Answer: mouse-derived MoAbs. pt develops human antimouse antibodies
creating high risk of hypersensitivity rx
end in -momab
3
, Monoclonal antibodies
Correct Answer: very specific. directed against single antigenic determinant on cell
surface causing antibody-dependent cellular toxicity, direct cell death, elimination of
antigen/target cell that expresses the antigen
low toxicity
-ximab
Correct Answer: moab combo of human & mouse antibodies
-zumab
Correct Answer: moab humanized, small part of mouse antibody fused w/ human
antibody
-umab
Correct Answer: fully humanized moabs
chimeric moab
Correct Answer: murine variable & human constant coupled using recombinant dna
purpose of moabs
Correct Answer: attach low-dose radioisotopes to image residual disease. target
chemo, radiation, biotherapy to tumor
purge autologous bone marrow of cancer cells before transplant
4
