BIOL 2200: Case Study 2 Questions and Verified Answers | Passed | A+

What kind of hypersensitivity is Anna experiencing and how do you know? : Hypersensitivity Type 1, her total serum IgE was high. Why won't someone experience any allergy symptoms when stung previously? : They aren't sensitized at that point, there is not enough IgE antigen bound. Decsribe the mechanism of a Type 1 reaction after the first sensitization. : (After being re-exposed to the allergen, immediate response-symptoms occur 5-30 minutes after exposure.) The antigen enters the system and binds to the arms of the IgE which is bound to mast cells. Mast cells release granule contents (degranulation) which releases histamine which causes inflammation. (Increases vascular permeability and increases vasodilation.) What is the cause of tightness in the chest and problems breathing? : Release of histamine resulting in bronchoconstriction. 2 What is anaphylaxis? : A potentially life-threatening type of hypersensitivity reaction that can cause a rash, wheezing, low blood pressure and tachycardia. What is anaphylactic shock? : Inflammatory mediators can cause massive systemic vasodilation that effects the respiratory and circulatory system. Life threatening* Why did Ana lose consciousness every time she attempted an upright position? : Her blood pressure is not strong enough, (due to the release of histamine) to pump blood and oxygen to the brain