Clinical Pharmacology Test Bank with Questions and Answers

Drug substance that alters physiologic function regardless of benefit or harm Pharmaco-therapeutics use of specific drugs to prevent, treat or diagnose disease Toxicology study of harmful effects of chemicals Pharmacokinetics -absorption -metabolism -distribution -excretion Pharmacodynamics mechanism of action Pharmacogenomics study of how genes affect patient's response to drugs Chemical name refers to specific structure of compound Generic name derived from chemical name (commonly used), ex. Ibuprofen Generic equivalent contains essentially identical amounts of active ingredients whose efficacy is supported by blood level data evaluated by the FDA Trade name assigned by pharmaceutical company, same generic drug can have different trade names (Motrin, Advil) Therapeutic equivalent drug product contains different chemical ingredients that have the same pharmacological/therapeutic effect (Motrin, Aleve) Branded generic prescription products that are either novel dosage forms of off-patent products produced by a manufacturer that is not the originator of the molecule, or a molecular copy of an off patent product with a trade name Examples of branded generic -extended-release oxycodone (OxyContin) -levothyroxine (Levothyroid) -digoxin (Digitek) -OCPs (Errin, Jolivette, Cryselle