Immunology Final Exam Questions with 100% Correct Answers | Latest Version 2024 | Verified

Which of the following is NOT TRUE about NK cells? a. Possess cytoplasmic granules containing perforin and granzymes. b. NK cells are involved in the early response to infection with certain viruses and intracellular bacteria and can kill tumor cells. c. NK cells are lymphoid cells. d. Similar to T and B cells, activated NK cells proliferate and differentiate into separate effector cells in order to function. e. Make up 10-15% of human peripheral blood cells. - d. Similar to T and B cells, activated NK cells proliferate and differentiate into separate effector cells in order to function. Which of the following is NOT TRUE about NK cells and various cytokines? a. NK cells produced TNF can mediate cytotoxicity. b. NK cell produced IFN-gamma enhances Th2 cell development. c. Resting NK cells don't usually acquire significant cytolytic competence until they are primed through exposure to cytokines. d. NK activity is stimulated IFN-alpha, IFN-beta, & IL-12. e. NK cells produce IFN-gamma upon activation which can influence the innate immunity by activation of macrophages. - b. NK cell produced IFN-gamma enhances Th2 cell development. Which of the following statement is NOT TRUE about NK cells and their receptors? a. NK cells recognize abnormal cells based on "missing self" model. b. NK cells display both inhibitory & activating receptors on their surface and recognize abnormal cells based on the "opposing signals" model. c. NK cells recognize the presence of MHC class I on the surface of target cells and this recognition provides them an activating signal to kill MHC class I positive target cells. d. The opposing functions of activating & inhibitory receptors can be attributed to differences in their intracellular domains.e. Intensity of NK cell response is determined by how many inhibitory versus activating receptors are engaged and affinity of those receptors to their ligands. - c. NK cells recognize the presence of MHC class I on the surface of target cells and this re