BISC 2070 Final Siebenlist
Entry of acetyl-CoA into the citric acid cycle is increased when:
a) the ratio of [ATP]/[ADP] is low
b) [AMP] is low
c) the ratio of [NAD]/[NADH] is high
d) [ADP] is low
e) a & c - correct answer-e) a & c
How many nucleotides are in 2 turns of the DNA double helix?
a) five
b) ten
c) fifteen
d) twenty
e) thirty - correct answer-d) twenty
The ATP generated during the TCA Cycle is formed by a process known as
a) reductive phosphorylation
b) oxidative phosphorylation
c) substrate level phosphorylation
d) cis-phosphorylation
e) trans-phosphorylation - correct answer-c) substrate level phosphorylation
Which vitamin is a required coenzyme for the hydroxylation of proline and lysine amino acids
in collagen?
a) Vitamin A
b) Vitamin B
c) Vitamin K
d) Vitamin C
e) Vitamin E - correct answer-d) Vitamin C
Which DNA base pair is held together by two hydrogen bonds?
a) thymine and guanine
b) cytosine and guanine
c) adenine and guanine
d) cytosine and thymine
e) adenine and thymine - correct answer-e) adenine and thymine
Uracil is one example of a heterocyclic base that is a
a) purine
,b) cofactor
c) phosphodiester
d) pyrimidine
e) 5-carbon sugar - correct answer-d) pyrimidine
What two products are formed during the reaction between a fatty acid and an alcohol?
a) ester and hydrogen
b) ester and water
c) ether and water
d) ether and hydrogen
e) hydrogen and alkane - correct answer-b) ester and water
The functional group of the cytochromes is:
a) CoQ
b) FMN
c) heme
d) iron-sulfur clusters
e) lymph - correct answer-c) heme
______ is a homopolysaccharide that provides a source of dietary fiber
a) starch
b) cellulose
c) dermatin
d) sucorse
e) glucose - correct answer-b) cellulose
All of the following will denature a protein EXCEPT:
a) Hg
b) urea
c) pH 1
d) 4° C
e) benzene - correct answer-d) 4° C
It is possible to convert the Ala that is a part of Ala-tRNA Ala to Ser by a catalytic
hydroxylation. If the resulting Ser-tRNA Ala were added to a reaction mixture containing all
of the other components necessary for translation, where in the newly synthesized protein
would the Ser from Ser-tRNA Ala be incorporated?
a) wherever Ala normally occurs
b) wherever Ser normally occurs
c) wherever either Ala or Ser normally occurs
d) wherever the dipeptide Ala-Ser normally occurs
e) nowhere; this is the equivalent of a nonsense mutation - correct answer-a) wherever Ala
normally occurs
,Which one of the following is an INCORRECT statement?
a) vitamin A is necessary for normal skin integrity
b) vitamin D is necessary to maintain normal calcium levels
c) vitamin E is an anti-oxidant
d) vitamin K is necessary for normal clotting
e) all of the above statements are true - correct answer-e) all of the above statements are
true
The animal fatty acid synthase is a single multifunctional protein able to carry out the six
reactions of the pathway. Which of the following is an advantage of this arrangement over
the production of seven different enzymes?
a) the Km for the first enzyme in the pathway will be lower
b) the ACP can be covalently attached
c) it is easier to run the reactions in either the forward (biosynthesis) or reverse (B-oxidation)
direction, enhancing cellular regulation
d) dilution of intermediates in the pathway is minimized
e) none of the above - correct answer-d) dilution of intermediates in the pathway is
minimized
All of the following statements are true EXCEPT:
a) triacyglycerols are used as an energy source
b) most of the energy stored in the body is in the form of lipids
c) glycogen is a polysaccharide used for storing energy
e) lipids are stored in fat cells called adipocytes
e) lipids release ten times more energy than carbohydrates when oxidized - correct
answer-b) most of the energy stored in the body is in the form of lipids
Okasaki Fragments are
a) small pieces of DNA synthesized during replication
b) small pieces of DNA synthesized during transcription
c) small pieces of DNA synthesized during translation
d) small pieces of RNA synthesized during transcription
e) small pieces of protein synthesized during translation - correct answer-a) small pieces of
DNA synthesized during replication
The fundamental repeating unit of of organization in a eukaryotic chromosome is:
a) the centrosome
b) the nucleosome
c) the lysosome
e) the microsome
e) none of the above - correct answer-b) the nucleosome
, Hexokinase catalyzes the transfer of phosphate from ATP to D-glucose, but not to L-glucose.
This is an example of _______
a) group specificity
b) linkage specificity
c) stereospecificity
d) absolute specificity
e) noncompetitive specificity - correct answer-c) stereospecificity
Complexes I, III, and IV of the electron transport chain
a) pumps Ca2+ to generate a Ca2+ gradient
b) pumps electrons to generate an electron gradient
c) pumps protons to generate a proton gradient
d) transfers electrons from FAD to O2
e) transfers electrons from NAD+ to O2 - correct answer-c) pumps protons to generate a
proton gradient
All of the following events occur during the elongation phase of translation EXCEPT
a) tRNA containing the next amino acid binds to the codon in the A site
b) peptidyl transferase forms a peptide bond
c) ribosome translocates one codon toward the 5' end of the mRNA
d) GTP is hydrolyzed to GDP and PO4
e) tRNA containing the growing peptide chain is in the P site - correct answer-c) ribosome
translocated one codon toward the 5' end of the mRNA
GTP hydrolysis to GDP and PO4 -3 is essential for all of the following EXCEPT
a) the formation of the initiation complex
b) elongation step of translation
c) the translocation step of translation
d) the termination of translation
e) it is essential for all of the above - correct answer-e) it is essential for all of the above
In nearly all DNA, the molar quantity of adenine equals that of
a) thymine
b) cytosine
c) guanine
d) uracil
e) none of the above - correct answer-a) thymine
Lactase catalyzes the cleavage of lactose to galactose and glucose. It belongs to which
class of enzymes?
a) lyase
b) hydrolase
c) oxioreductase
Entry of acetyl-CoA into the citric acid cycle is increased when:
a) the ratio of [ATP]/[ADP] is low
b) [AMP] is low
c) the ratio of [NAD]/[NADH] is high
d) [ADP] is low
e) a & c - correct answer-e) a & c
How many nucleotides are in 2 turns of the DNA double helix?
a) five
b) ten
c) fifteen
d) twenty
e) thirty - correct answer-d) twenty
The ATP generated during the TCA Cycle is formed by a process known as
a) reductive phosphorylation
b) oxidative phosphorylation
c) substrate level phosphorylation
d) cis-phosphorylation
e) trans-phosphorylation - correct answer-c) substrate level phosphorylation
Which vitamin is a required coenzyme for the hydroxylation of proline and lysine amino acids
in collagen?
a) Vitamin A
b) Vitamin B
c) Vitamin K
d) Vitamin C
e) Vitamin E - correct answer-d) Vitamin C
Which DNA base pair is held together by two hydrogen bonds?
a) thymine and guanine
b) cytosine and guanine
c) adenine and guanine
d) cytosine and thymine
e) adenine and thymine - correct answer-e) adenine and thymine
Uracil is one example of a heterocyclic base that is a
a) purine
,b) cofactor
c) phosphodiester
d) pyrimidine
e) 5-carbon sugar - correct answer-d) pyrimidine
What two products are formed during the reaction between a fatty acid and an alcohol?
a) ester and hydrogen
b) ester and water
c) ether and water
d) ether and hydrogen
e) hydrogen and alkane - correct answer-b) ester and water
The functional group of the cytochromes is:
a) CoQ
b) FMN
c) heme
d) iron-sulfur clusters
e) lymph - correct answer-c) heme
______ is a homopolysaccharide that provides a source of dietary fiber
a) starch
b) cellulose
c) dermatin
d) sucorse
e) glucose - correct answer-b) cellulose
All of the following will denature a protein EXCEPT:
a) Hg
b) urea
c) pH 1
d) 4° C
e) benzene - correct answer-d) 4° C
It is possible to convert the Ala that is a part of Ala-tRNA Ala to Ser by a catalytic
hydroxylation. If the resulting Ser-tRNA Ala were added to a reaction mixture containing all
of the other components necessary for translation, where in the newly synthesized protein
would the Ser from Ser-tRNA Ala be incorporated?
a) wherever Ala normally occurs
b) wherever Ser normally occurs
c) wherever either Ala or Ser normally occurs
d) wherever the dipeptide Ala-Ser normally occurs
e) nowhere; this is the equivalent of a nonsense mutation - correct answer-a) wherever Ala
normally occurs
,Which one of the following is an INCORRECT statement?
a) vitamin A is necessary for normal skin integrity
b) vitamin D is necessary to maintain normal calcium levels
c) vitamin E is an anti-oxidant
d) vitamin K is necessary for normal clotting
e) all of the above statements are true - correct answer-e) all of the above statements are
true
The animal fatty acid synthase is a single multifunctional protein able to carry out the six
reactions of the pathway. Which of the following is an advantage of this arrangement over
the production of seven different enzymes?
a) the Km for the first enzyme in the pathway will be lower
b) the ACP can be covalently attached
c) it is easier to run the reactions in either the forward (biosynthesis) or reverse (B-oxidation)
direction, enhancing cellular regulation
d) dilution of intermediates in the pathway is minimized
e) none of the above - correct answer-d) dilution of intermediates in the pathway is
minimized
All of the following statements are true EXCEPT:
a) triacyglycerols are used as an energy source
b) most of the energy stored in the body is in the form of lipids
c) glycogen is a polysaccharide used for storing energy
e) lipids are stored in fat cells called adipocytes
e) lipids release ten times more energy than carbohydrates when oxidized - correct
answer-b) most of the energy stored in the body is in the form of lipids
Okasaki Fragments are
a) small pieces of DNA synthesized during replication
b) small pieces of DNA synthesized during transcription
c) small pieces of DNA synthesized during translation
d) small pieces of RNA synthesized during transcription
e) small pieces of protein synthesized during translation - correct answer-a) small pieces of
DNA synthesized during replication
The fundamental repeating unit of of organization in a eukaryotic chromosome is:
a) the centrosome
b) the nucleosome
c) the lysosome
e) the microsome
e) none of the above - correct answer-b) the nucleosome
, Hexokinase catalyzes the transfer of phosphate from ATP to D-glucose, but not to L-glucose.
This is an example of _______
a) group specificity
b) linkage specificity
c) stereospecificity
d) absolute specificity
e) noncompetitive specificity - correct answer-c) stereospecificity
Complexes I, III, and IV of the electron transport chain
a) pumps Ca2+ to generate a Ca2+ gradient
b) pumps electrons to generate an electron gradient
c) pumps protons to generate a proton gradient
d) transfers electrons from FAD to O2
e) transfers electrons from NAD+ to O2 - correct answer-c) pumps protons to generate a
proton gradient
All of the following events occur during the elongation phase of translation EXCEPT
a) tRNA containing the next amino acid binds to the codon in the A site
b) peptidyl transferase forms a peptide bond
c) ribosome translocates one codon toward the 5' end of the mRNA
d) GTP is hydrolyzed to GDP and PO4
e) tRNA containing the growing peptide chain is in the P site - correct answer-c) ribosome
translocated one codon toward the 5' end of the mRNA
GTP hydrolysis to GDP and PO4 -3 is essential for all of the following EXCEPT
a) the formation of the initiation complex
b) elongation step of translation
c) the translocation step of translation
d) the termination of translation
e) it is essential for all of the above - correct answer-e) it is essential for all of the above
In nearly all DNA, the molar quantity of adenine equals that of
a) thymine
b) cytosine
c) guanine
d) uracil
e) none of the above - correct answer-a) thymine
Lactase catalyzes the cleavage of lactose to galactose and glucose. It belongs to which
class of enzymes?
a) lyase
b) hydrolase
c) oxioreductase
