Peptic Ulcer Disease Exam Questions With 100% Correct Answers

Peptic Ulcer Disease Exam Questions With 100% Correct Answers peptic ulcer disease - answera group of upper GI disorders characterized by varying degrees of erosion of the gut wall •Name two complications of PUD - answerhemorrhage and perforation •Name two locations where peptic ulcers are most common - answerlesser curvature of the stomach and duodenum •When do peptic ulcers develop? - answerwhen there is an imbalance between mucosal defensive factors and aggressive factors. •Name the two major defensive factors against ulceration. - answermucus and bicarbonate •Name the four major aggressive factors for ulceration - answerH. pylori, NSAIDs, gastric acid, and pepsin •Name the two most important agents that can weaken defenses against ulceration - answerH. pylori, NSAIDs •Explain how prostaglandins play an important role in maintaining defenses. - answerstimulate secretion of mucus and bicarbonate; promote vasodilation, which helps maintain submocosal blood flow; and suppress secretion of gastric acid Helicobacter pylori - answera gram negative bacillus that can colonize the stomach and duodenum •Explain how NSAIDs are the underlying cause of many gastric ulcers and some duodenal ulcers. - answerinhibit the biosynthesis of prostaglandins •True or False? Patients with gastric ulcers produce an increased amount of gastric acid. - answerFalse •Name one life-style habit that delays ulcer healing and increases the risk of recurrence. - answersmoking •Name the first and second most common causes of gastric and duodenal ulcers. - answerH. pylori, NSAIDs •Name four goals of drug therapy for PUD. - answer(1) alleviate symptoms, (2) promote healing, (3) prevent complications, and (4) prevent recurrence. •Name the five classes of antiulcer drugs. - answerantibiotics, antisecretory agents, mucosal protectants, antisecretory agents that enhance mucosal defenses, and antacids •Name the three basic ways drugs used for PUD act to promote ulcer healing. Identify classes of drugs that perform each action. - answer(1) eradicate H. pylori (anitbiotics), (2) reduce gastric acidity (antisecretory agents, misoprostol, and antacids), and (3) enhance mucosal defenses (sucralfate and misoprostol) •Name the 2 preferred drug options for prevention of NSAID-Induced Ulcers. - answermisoprostol and the proton pump inhibitors •Name the 2 preferred drug options for treatment of NSAID-Induced Ulcers - answerhistamine2-receptor blockers and proton pump inhibitors •What common diet restrictions have not been shown to accelerate healing of PUD? What is one dietary change that may be beneficial? - answer"ulcer diet"-bland foods together with milk or cream; eating pattern of 5 or 6 small meals a day may be beneficial •What life-style habit should be avoided by patients with PUD? - answersmoking •What group of patients with PUD may continue to take aspirin? Why? - answeruse of aspirin to prevent cardiovascular disease •What restriction should be placed on alcohol consumption by patients with PUD? - answerstop if patient notes a temporal relationship between consumption and exacerbation of symptoms •What invasive procedure is necessary to obtain a biopsy to conduct tests for H. pylori? - answeran endoscopically obtained biopsy sample •Name three types of noninvasive tests used in the United States to test for H. pylori. - answerbreath, serologic and stool tests •Name the five antibiotics used to treat PUD caused by Helicobacter pylori. Which ones can be used alone? - answeramoxicillin, clarithromycin, bismuth, metronidazole, and tetracycline. None. •List the antibiotics used in order of least resistance to most resistance (not including Bismuth). - answertetracycline (1%), amoxicillin (3%), clarithromycin (10%), metronidazole (40%) •Name one common side effect that Amoxicillin and Clarithromycin have in common. Name two additional side effects of Clarithromycin. - answerdiarrhea nausea, and distortion of taste