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Rh System Blood Group System SBB Solutions A+ Graded

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Antigen Expression - Correct Answer Erythroid specific No soluble form The D antigen is encoded by... - Correct Answer RHD gene The C,c E, and e are encoded by... - Correct Answer RHCE gene RHD and RHCE are found - Correct Answer Chromosome 1 Rh complex - Correct Answer RHD RHCE Rh associated glycoprotein (RhAG) LW glycoprotein CD47 Integrin-associated protein Glycophorin B Fy5 RHCE protein and position - Correct Answer C= serine at position 103 c= proline at position 103 E= proline at position 226 e= alanine at position 226 Weak D - Correct Answer Qualitiative - inherited gene that encodes less than normal of D antigen sites Position effect - weakening of the D antigen by a C gene in trans to the D gene Partial D- lack part of the D antigen complex Del- adsorb and elute anti-D to detect D antigen (Asians) Rhnull - Correct Answer -Regulator effect-mutation in the RHAG gene that results in complete absence of Rh complex. Transmit normal RHD and RHCE genes to offspring -Amorph type- normal RHAG gene. Mutation in each RHCE gene along with common deletion of RHD -RHmod-reduced activity of Rh antigens. Mutation in RHAG gene -Sensitized persons can make anti-Rh29 (total Rh) -Absence of LW and Fy5 antigens -stomatocytosis -Shorten RBC survival -Altered glycophorin B

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