ONS Chemotherapy Immunotherapy Exam With Complete And Verified Questions And Answers 2024

ONS Chemotherapy Immunotherapy Exam With Complete And Verified Questions And Answers 2024 3 major phases of cell division: - correct answer.Interphase Mitotic phase Cytokinesis 3 steps of interphase: - correct answer.First growth phase (G1) Synthesis phase (S phase) Second growth phase (G2) 4 phases of mitosis: - correct answer.Prophase Metaphase Anaphase Telophase Innate immunity: - correct answer.Non-specific response, either: 1. Barrier (skin, mucous membranes, flora of skin/gut) 2. Cellular components (phagocytes, natural killer cells, granulocytes, macrophages) Adaptive immunity: - correct answer.Follows innate immunity if unsuccessful. Memory immunity, including: 1. Humoral immunity (production of antibodies or immunoglobulins) 2. Cell mediated immunity (dependent upon T cells) 3. Regulatory T -cells (prevent autoimmune reactions and limit inflammatory responses) Define mutations - correct answer.Variations in the nucleotide sequence of a gene 3 main goals of treatment: - correct answer.Cure Control Palliation Define neoadjuvant therapy - correct answer.Treatment is given prior to surgery to shrink the tumor Define adjuvant therapy - correct answer.Additional cancer treatment given after the primary treatment to lower the risk that the cancer reoccur Define conditioning/preparative therapy - correct answer.Treatments used to prepare a patient for stem cell transplantation 2 types of conditioning therapies: - correct answer.Myeloablative Nonmyeloablative Define dose density - correct answer.Drug dose per unit of time Define dose intensity - correct answer.Amount of drug delivered over time How is relative dose intensity (RDI) calculated? - correct answer.By comparing the dose that the patient ACTUALLY received to the planned dose of the standard regimen How do alkylating agents work? - correct answer.By causing a break in the DNA helix strand, interfering with DNA replication and causing cell death 3 subcategories of alkylating agents: - correct answer.1. Nitrogen mustards 2. Platinum-based agents (do not possess an alkyl group but still termed alkylating agents as they work similarly) 3. Nitrosoureas Most common subcategory of alkylating agents: - correct answer.Nitrogen mustards Common alkylating agents: - correct answer.Cyclophosphamide (Cytoxan) Ifosfamide (Ifex) Bendamustine (Treanda) Common platinum-based agents: - correct answer.Cisplatin (Platinol) Carboplatin (Paraplatin) What is unique about nitrosoureas agents? - correct answer.Able to cross the blood-brain barrier; can be effective in treating some brain tumors Common nitrosoureas agents: - correct answer.Carmustine (BiCNU) Lomustine (CeeNu) Streptozocin (Zanosar) Hypersensitivity can occur with late doses of: - correct answer.Carboplatin These agents are typically categorized as highly emetogenic: - correct answer.1. Alkylating agents 2. Nitrosoureas Pre-administration labs for alkylating agents and nitrosoureas: - correct answer.BUN Creatinine CBC w/ diff What is the medication Mesna used for? - correct answer.Bladder protectant with administration of cyclophosphamide or ifosfamide Instruct pts receiving ________ to avoid exposure to cold air and consuming cold fluids for 3-4 days following treatment - correct answer.Oxaliplatin How do antimetabolites function? - correct answer.By blocking DNA and RNA growth by interfering with enzymes needed for normal cell metabolism Antimetabolites work in the ___ phase. - correct answer.S What types of cells are best affected by antimetabolites? - correct answer.Cells with high division rates Common side effects of antimetabolites: - correct answer.Myelosuppression GI toxicities Photosensitivity Hand-foot syndrome Common antimetabolite drugs: - correct answer.Azacitidine Capecitabine 5-FU Cytarabine Decitabine Methotrexate The institute for Safe Medication Practices recommends what route of administration for vincristine? - correct answer.IV piggyback via gravity Anthracycline antitumor abx work by: - correct answer.Interfering with enzymes necessary for DNA to replicate in ALL phases of the cell cycle The two major classifications of antitumor antibiotics are: - correct answer.Anthracyclines Non-anthracyclines Common anthracycline antitumor abx: - correct answer.Daunorubicin Doxorubicin Epirubicin Idarubicin