NR 546 Week 5 Antidepressant and Mood Stabilizer Medication Table latest update 2024 GRADED A+

Indication, starting dose, target symptoms, and affected neurotransmitters Half-life (T1/2) CYP450 enzyme Notes/Notable side effects/Precautions SSRIs Citalopram (Celexa) Selective serotonin reuptake inhibitor Commonly prescribed for depression, PMDD, OCD, panic disorder, GAD, PTSD, social anxiety disorder Starting dose: 20mg/day Blocks serotonin and serotonin reuptake pump, desensitizes serotonin receptors, presumably increases serotonergic neurotransmission Parent drug 23-45 hour half-life. Weak inhibitor of CYP450 2D6. Metabolized by CYP450 3A4 and 2C19 Notable side effects: sexual dysfunction, decreased appetite, N/V/D, constipation, dry mouth, dose-dependent insomnia, agitation, tremors, headache, dizziness, sweating, bruising and rare bleeding. Precautions: rare seizures, rare mania, rare activation of suicidal ideation, sedation. Caution with patients with seizure disorders, bipolar disorder, monitor for SI in children and adolescents Notes: mild antihistamine properties may contribute to sedation and fatigue in some. Risks versus benefits in pregnancy and breast feeding. Escitalopram (Lexapro) Selective serotonin reuptake inhibitor Commonly prescribed for MDD, GAD, panic disorder, OCD, PTSD, social anxiety disorder, and PMDD Starting dose: 10mg/day Blocks serotonin and serotonin reuptake pump, desensitize