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Penicillin structureBeta-lactam ring Are penicillins bactericidal or bacteriostatic?bactericidal Penicillin benefitsSafest of all antibiotics because it has no direct effect on the host. Beta-lactam antibiotics1. Cephalosporins 2. Aztreonam 3. Cerbapeniems Beta-lactam antibiotics mechanism of actionDisrupt bacterial cell wall PCN mechanism of action1. Weaken the cell wall and cause bacteria cell to take up excessive amounts of water and rupture 2. It inhibits transpeptidase (enzyme critical to cell wall synthesis). 3. Activation of autolysins (bacterial enzymes that cleave bonds in cell wall). Penicillin binding proteins (PBPs)Molecular targets of penicillin
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