Stahl's Chapter 3 Exam#2 questions with complete solution

Stahl's Chapter 3 Exam#2 questions with complete solution What are the 2 major classes of ion channels? - Correct Answers Ligand-gated ion channel and Voltage-sensitive or voltage gated ion channels What ions are regulated by ion channels? - Correct Answers Calcium, Sodium and potassium A neurotransmitter, drug, or hormone that binds to a receptor is called a - Correct Answers Ligand (mostly neurotransmitter) A ligand-gated ion channel functions as 2 things - Correct Answers a receptor and an ion channel (hence they can be called ligand-gatedion channels, ionotropic receptors, and ion channel linked receptors) What is the function of an ion channel? - Correct Answers Because of there structure of long strands that assemble into subunits they have multiple binding sites, where allosteric binding sites/modulators increase or decrease the opening of the channel. Why are many ligand-gated channels called 5 protein sunbunits? - Correct Answers Pentameric and each channel has 4 transmembrane regions 4 transmembrane regions make 1 subunit and 5 subunits make? - Correct Answers A pentameric(5 parts) ion channel These 5 subunits come together to make a - Correct Answers fully functional unit with binding sites inside and outside Acetylcholine is a neurotransmitter of a pentameric ligand-gated ion channel and the recptor type is - Correct Answers Nicotinic receptors GABA in pentameric with - Correct Answers GABA A receptors Glycine is a pentameric with - Correct Answers Strychnine-sensitive glycine recptors Serotonin is a pentameric with - Correct Answers 5HT3 receptors Four copies (of the 3 subunits) come together to make - Correct Answers Tetrameric ligand-gated ion channel (4 parts) Glutamate is a Tetrameric with - Correct Answers NMDA, AMPA and KAINATE subunits GABA is a - Correct Answers full agonist, benzo's and "z" drugs Zolpidem Acetylcholine - Correct Answers is a partial agonist glutamate and serotonin - Correct Answers antagonist Agonists - Correct Answers maximum opening and more frequently in short bursts of time partial agonist - Correct Answers not open as fully or as frequently as agonist Antagonist - Correct Answers back to resting state; constitutive state inverse agonist - Correct Answers goes beyond baseline,