UNE BIOCHEM FINAL TEST QUESTIONS WITH COMPLETE SOLUTIONS, Rated A+

Under fasting conditions (ratio of insulin to glucagon 1), elevated glucagon will activate which of the following enzymes? - Hormone sensitive lipase The process of ketogenesis refers to the conversion of acetyl CoA to which of the following compounds? - D-3-hydroxybutyrate or B-hydroxybutyrate During the fasted state, lipolysis is facilitated by the action of hormone sensitive lipase. This enzyme requires which of the following post - translational modification for activation? - Phosphorylation A 10-year old boy is brought to the emergency department by his father. He reports his son has recently been very thirsty and needing to make frequent trips to the bathroom. Physical examination revealed a thin boy, in the 30th percentile for height and weight. A rapid dipstick test revealed glucose in his urine. Evaluation of the boy's blood would reveal decreased levels of which of the following compounds or hormones? - Insulin Which of the following is not a product of B-oxidation? - NADPH A 22-year old woman engaging in a political protest goes on a hunger strike on a prominent corner in a city park. She refuses all offers of food except for water through the first 2 weeks. Under these conditions there is a decreased reliance on which of the following pathways for fuel? - Gluconeogenesis An 11-year old girl is brought to the emergency department by her father. He reports she has recently been very thirsty and needing to make frequent trips to the bathroom. At her soccer game today, she complained of lightheadedness and the symptoms did not resolve even after drinking a power beverage. A rapid dipstick test revealed glucose in her urine and further diagnostics were consistent with a diagnosis of type 1 diabetes. Evaluation of this girl's liver would reveal an increased rate of which of the following processes? - Ketogenesis A well, 2-year old girl presents to the clinic with symptoms of a viral illness. Her parents report she has had bouts of vomiting and diarrhea over the last 24 hours. This morning they could barely wake her up from her crib and she was very weak. Laboratory tests show low blood glucose (hypoglycemia) and elevated liver enzymes. There are no ketones present in her urine. The child is hospitalized and glucose is administered by I.V. Additional laboratory analysis showed elevated medium-chain fatty acyl carnitines in blood and 6-8 carbon dicarboxylic acids in the urine. Which of the following abnormalities is the most likely diagnosis for this child? - Defect of medium-chain acyl-dehydrogenase. NADPH is essential for fatty acid synthesis can be generated by which of the following enzymes? - Glucose 6-phosphate dehydrogenase Malic enzyme (1) An increase in the ratio of insulin to glucagon will increase the activity of which of the following enzymes? - Acetyl-CoA PFK2 Glycogen synthase (4)