Test Bank for Rau’s Respiratory Care Pharmacology 9th Edition By Gardenhire | Chapter 1-23 | Complete Updated Guide.

Test Bank for Rau’s Respiratory Care Pharmacology 9th Edition By Gardenhire | Chapter 1-23 | Complete Updated Guide. Test Bank for Rau’s Respiratory Care Pharmacology, 9th Edition, Gardenhire, ISBN-10: 0323299687, ISBN-13: 9780323299688 Table of Contents Unit I: Basic Concepts and Principles in Pharmacology 1. Introduction to Respiratory Care Pharmacology 2. Principles of Drug Action 3. Administration of Aerosolized Agents 4. Calculating Drug Doses 5. The Central and Peripheral Nervous Systems Unit II: Drugs Used to Treat the Respiratory System 6. Adrenergic (Sympathomimetic) Bronchodilators 7. Anticholinergic (Parasympatholytic) Bronchodilators 8. Xanthines 9. Mucus-Controlling Drug Therapy 10. Surfactant Agents 11. Corticosteriods in Respiratory Care 12. Nonsteroidal Antiasthma Agents 13. Aerosolized Antiinfective Agents 14. Antimicrobial Agents 15. Cold and Cough Agents 16. Selected Agents of Pulmonary Value 17. Neonatal and Pediatric Aerosolized Drug Therapy Unit III: Critical Care, Cardiovascular, and Polysomnography Agents 18. Skeletal Muscle Relaxants (Neuromuscular Blocking Agents) 19. Diuretic Agents 20. Drugs Affecting the Central Nervous System 21. Vasopressors, Inotropes, and Antiarrythmic Agents 22. Drugs Affecting Circulation: Antihypertensives, Antianginals, Antithrombotics 23. Sleep and Sleep Pharmacology Chapter 01: Introduction to Respiratory Care Pharmacology Gardenhire: Rau’s Respiratory Care Pharmacology, 9th Edition MULTIPLE CHOICE 1. What is the name of the receptor sites that are located in the peripheral vasculature, the heart, bronchial muscle, and bronchial blood vessels? a. Beta 2 receptors c. Alpha receptors b. Gamma receptors d. Beta 1 receptors ANS: C Alpha receptors are located in the peripheral vasculature, the heart, bronchial muscle, and bronchial blood vessels. PTS: 1 2. Which receptor site results in tachycardia, an increased potential for arrhythmias, and an increased cardiac output? a. Beta 1 receptor c. Alpha receptor b. Beta 2 receptor d. Delta receptor ANS: A Stimulation of the beta-1 receptors results in tachycardia, an increased potential for arrhythmias, and an increased cardiac output. In administering drugs to the pulmonary system, stimulation of the beta-1 sites is not desired. However, most respiratory pharmacologic agents have some beta-1 stimulatory effect. PTS: 1 3. Stimulation of the beta 2 receptors causes a. peripheral vasoconstriction and mild bronchoconstriction in the lungs. b. tachycardia, an increased potential for arrhythmias, and an increased cardiac output. c. bronchodilation. d. peripheral vasodilation, bradycardia, and decreased cardiac output. ANS: C Stimulation of the beta-2 receptors in the lungs causes bronchodilation. PTS: 1 4. Acetylcholine stimulates a. the Vagus nerve. b. the adrenergic receptors. c. the sympathetic nervous system. d. the cholinergic receptors. ANS: D Acetylcholine stimulates the cholinergic receptors. PTS: 1 5. What immunoglobulin antibody sensitizes the mast cell? a. Leukotrienes c. Histamine b. IgE d. Prostaglandins ANS: B The IgE (reagin) antibodies sensitize the mast cell. Repeated exposure to the antigen causes the degranulation of the mast cell. PTS: 1 6. Which of the following is caused by histamine release from the mast cells? I. Bronchodilation II. Increased bronchial gland secretion III. Increased amount of mucus present in the airways a. I and II only c. III only b. II and III only d. I, II, III ANS: B Histamine is also a potent bronchoconstrictor. In addition to its bronchoconstrictive activity, histamine II) increases bronchial gland secretion, causing III) an increase in the amount of mucus present in the airways. Histamine may also have an effect on vascular permeability similar to the effect ofSRS-A. PTS: 1 7. A sympathomimetic drug would cause a. bronchodilation. c. Histamine release. b. bronchoconstriction. d. Vagus nerve stimulation. ANS: A A sympathomimetic drug would cause bronchodilation. Sympathomimetic agents are the drugs most commonly used to reverse bronchospasm. PTS: 1 8. Stimulation of the sympathetic nervous system causes a. vascular permeability. c. bronchodilation. b. decreased blood pressure. d. bronchoconstriction. ANS: C Sympathetic nervous system stimulation causes bronchodilation. PTS: 1 9. Which of the following would NOT cause a bronchospasm or bronchoconstriction? a. Leukotrienes c. Histamine b. Beta 1 receptors d. Prostaglandins ANS: B Beta-1 receptors would not cause a bronchospasm or bronchoconstriction. Leukotrienes are one of many chemical mediators released by the mast cells. Leukotrienes cause a direct, strong bronchoconstriction. Histamine is also a potent bronchoconstrictor. Prostaglandins cause a strong bronchospasm, especially in asthmatic patients. PTS: 1 10. Place the following intracellular events of the Beta 2 receptor stimulation in order. I. Phosphodiesterase breaks down cyclic 3’, 5’-AMP into 5’-AMP II. Adenylate cyclase combines with magnesium and ATP to form cyclic 3’,5’-AMP III. Cyclic 3’,5’-AMP results in bronchial smooth muscle relaxation IV.Beta-2 stimulation causes the formation of adenylate cyclase a. I, II, III, IV c. IV, II, III, I b. III, IV, I, II d. IV, III, II, I ANS: C The following order is correct: IV) Beta-2 stimulation causes the formation of adenylate cyclase. II) Adenylate cyclase combines with magnesium and ATP (adenosine triphosphate) to form cyclic 3’,5’- AMP (adenosine monophosphate). III) Cyclic 3’,5’-AMP results in bronchial smooth muscle relaxation and hence bronchodilation. Cyclic 3’,5’-AMP is not a long-lived agent. It is readily broken down by another enzyme present in the lungs called phosphodiesterase. I) Phosphodiesterase breaks 3’,5’-AMP down into 5’-AMP, which no longer causes bronchodilation. PTS: 1 11. Release of acetylcholine will cause a. bronchodilation. c. stimulation of cyclic 3’5’ AMP. b. Mast cell stabilization. d. bronchospasm. ANS: D Cholinergic receptors are cells that respond when stimulated by acetylcholine. Cholinergic receptors cause profound bronchospasm in the lungs when stimulated. Cholinergic receptors are found in the parasympathetic nervous system. PTS: 1 12. Which of the following is NOT an example of a sympathomimetic drug? a. Salmeterol Xinafoate c. Pirbuterol Acetate b. Formoterol fumarate d. Atropine Sulfate ANS: D Atropine sulfate is a anti-cholinergic bronchodilator. Salmeterol, formoterol, and pirbuterol are all sympathomimetic bronchodilators. PTS: 1 13. Which of the following sympathomimetic drugs are intended for maintenance therapy only? I. Levalbuterol II. Salmeterol III. Formoterol IV.Pirbuterol a. II, III, and IV c. II and III b. I and IV d. I, II, III, and IV ANS: C II) Salmeterol and III) Formoterol are intended for maintenance therapy only. PTS: 1 14. A pediatric patient is admitted to the emergency department from a physician’s office with the suspected diagnosis of croup. An inspiratory stridor is heard. Which aerosolized sympathomimetic would you recommend to decrease the stridor? a. Racemic epinephrine c. Levalbuterol b. Albuterol d. Isoproterenol ANS: A Racemic epinephrine (Vaponephrine) is a sympathomimetic drug. However, its alpha effects are strong and it is commonly used to relieve croup and epiglottitis symptoms in children. PTS: 1 15. Aminophylline causes bronchodilation by a. stimulating the production of cyclic 3’5’ AMP. b. blocking the parasympathetic nervous system. c. inhibiting the enzyme phosphodiesterase. d. causing Mast cell degranulation. ANS: C Aminophylline is a phosphodiesterase inhibitor. It is an example of drugs in the xanthine group. Common phosphodiesterase drugs are found in the methylxanthine group. Cyclic 3’,5’-AMP is broken down into 5’-AMP by the enzyme phosphodiesterase. If the action of phosphodiesterase can be blocked or inhibited, more 3’,5’-AMP will remain in the lungs, resulting in better bronchodilation. Phosphodiesterase inhibitors act in this way. PTS: 1 16. Inhibition of the sympathetic nervous system would cause a. bronchoconstriction. b. stridor. c. bronchodilation. d. relaxation of the bronchial smooth muscle. ANS: A If the sympathetic nervous system is inhibited, it would cause bronchoconstriction.