Transfusion Medicine Study Material for CSMLS questions with correct answers

Transfusion Medicine Study Material for CSMLS questions with correct answers What would be the laboratory findings in a patient with a partial D phenotype? - CORRECT ANS-Patient cells will react weakly to reagent anti-D antibody What is the pathogenesis of alloanti-D antibodies in patients with a partial D phenotype? - CORRECT ANS-Patients lack certain antigenic components on their own D antigens, so they make anti-D to any red cells that express the full D protein. Give some reasons why a patient that expresses an Rh D phenotype may be found to have anti-D on screening. - CORRECT ANS-- Clerical error - Partial D RBC phenotype - Passive acquisition of anti-D from a red cell transfusion - Autoagglutinins What are the two most common causes of anti-D alloantibody? - CORRECT ANS-Alloimmunization through: - Transfusion or - Pregnancy What percentage of D-negative patients will develop anti-D antibody if transfused with D antigen positive red cells? - CORRECT ANS-~80% How much plasma is included in a unit of packed red cells that is preserved with CPDA? - CORRECT ANS-In CPDA units: 50 mL What is the frequency of the k antigen in the donor population? - CORRECT ANS-- 98.8% - This means that, if a k− patient needs a transfusion because they have an anti-k antibody, only 0.2% of donors will be compatible with this patient Are anti-M antibodies IgG or IgM? Are they normally clinically significant? - CORRECT ANS-- Anti-M tends to be IgG - Even though they are IgG, they are most often cold reactive antibodies and are therefore clinically insignificant What is the Cobalt (Co) antigen? - CORRECT ANS-It is found on the plasma membrane of red blood cells and renal tubular epithelial cells. It is on a protein called aquaporin-1 (AQP1 gene product), which is responsible for water homeostasis and urine concentration.