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Cpps 325 Final Exam Questions With Complete Solutions

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CPPS 325 FINAL EXAM QUESTIONS WITH COMPLETE SOLUTIONS What is src? - Answer-Src is a non-receptor TK, so it does not span a membrane. It is a tyrosine kinase. And although it is cytoplasmic TK it can still bind to activated RTKs. What is contact inhibition confluency? - Answer-Stops Src domains signalling and therefore cells stop dividing. If there is an issue then cancer can result and mutation causes an inhibition of the stop signal so the cells keep growing and dividing. What are SH domains? - Answer-Src homology domains. Src and other proteins that have src-homology domains can bing to activated RTKs. What are the different SH domains in proteins? - Answer-There are SH1, SH2 and SH3 domains. What isSH1 domain characterized by? - Answer-Catalytic domain of a protein, for example the receptor. and it has the kinase activity. It is responsible for phosphorylating tyrosine residues. What is SH2 domain characterized by? - Answer-Binds peptides with consensus (positional information on C-terminal side of the phosphorylated tyrosine). Very specific. Mediates protein-protein interactions in cellular signalling cascades. Very common in proteins outside the src family.

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