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Summary Epigenetics cancer therapy

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As a concept the “idea” of an “epigenetic code” has simplified the way we can describe the mechanistic elements that the cell uses to recognize and elicit epigenetic or aberrant epigenetic regulation in a cancer cell. Generally speaking, there are three “types” of regulatory protein known as “readers,” “writers,” or “erasers” of the epigenetic code. These are most generally associated with proteins that interact with histones through histone PTMs, although some have suggested a fourth category “remodeler,” while proteins, such as DNA methyltransferases, which modify DNA, have also been classified as “writers” [11]. Five main mechanisms allow the epigenetic machinery to regulate expression through: (1) DNA methylation; (2) chromatin accessibility; (3) histone modifications; (4) DNA protein interactions; and (5) chromatin tridimensional architecture [

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,Epigenetic Cancer Therapy

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, Translational Epigenetics


Epigenetic Cancer Therapy
Second Edition




Edited by
Steven G. Gray
Thoracic Oncology Research Group, The Trinity St James’s Cancer Institute (TSJCI),
St James’s Hospital, Dublin, Ireland; Thoracic Oncology Research Group, Institute of
Molecular Medicine, St. James’s Hospital, Dublin, Ireland; HOPE Directorate, St.
James’s Hospital, Dublin, Ireland; School of Medicine, Trinity College Dublin,
Dublin, Ireland; Thoracic Oncology Research Group, Central Pathology Laboratory,
St. James’s Hospital, Dublin, Ireland


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Steven Gray Epigenetic Cancer Therapy
Publisher: 2015 ISBN: 9780128002247 Edition: Unknown

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