MSN 622 - Hashimoto Thyroiditis (Well-enlightened)

What is hashimoto thyroiditis? correct answers autoimmune disease that destroys thyroid cells by cell and antibody-mediated immune processes What is the most common cause of hypothyroidism in developed countries? correct answers hashimoto Describe the pathology of hasimotos... correct answers formation of antithyroid antibodies that attack the thyroid tissue, causing progressive fibrosis What are the most common labs found in hashimotos? correct answers elevated thyroid-stimulating hormone (TSH) and low levels of free thyroxine (fT4), coupled with increased antithyroid peroxidase (TPO) antibodies What is conventional treatement of hashimotos? correct answers levothyroxine 1.6-1.8mcg/kg/day What is the most common thyroid antigen that patients may develop antibodies to in hashimotos? correct answers anti-thyroid peroxidase The development of hashimotos disease is thought to be of what origin? correct answers autoimmune origin with lymphocyte infiltration and fibrosis as typical features What type of symptoms might patients see in early phase of hashimotos? late phase? correct answers - early: hyperthyroidism - late: hypothyroidism What are the classic skin symptoms associated with hashimotos? correct answers - myxedema (severe cases) - scaly and dry skin - epidermal thinning - pale skin - slow hair growth - dry, coarse, dull, and brittle hair - diffuse or partial alopecia What cardiac/respiratory symptoms can be seen with hashimotos? correct answers - bradycardia - fatigue - exertional dyspnea - exercise intolerance What are some early symptoms that are commonly seen in hashimotos? correct answers - constipation - fatigue - dry skin