Pharmacology 3365 UTA Exam 1 With Correct Answers

Parmacogenetics - ANSWER the study of genetic differences in drug responses when referring to one gene Pharmacogenomics - ANSWER the study of variances in drug response when studying all genes Phenotype - ANSWER physical appearance/function from the genotype/environment Genetic polymorphism - ANSWER differences in alleles usually a single nucleotide variation that causes a person to respond differently to a drug. drug polymorphism - ANSWER effect of a patient's age, gender, size, body composition and other characteristics on the pharmacokinetics of specific drugs What are the difference regarding FDA approval for prescription, OTC, herbal supplements - ANSWER Prescription and OTC are FDA approved and Herbal supplements are NOT FDA approve can cause side effects Clinical trials 1 - ANSWER pharmacokinetics and metabolism clinical trials 2 - ANSWER effectiveness and adverse effect clinical trials 3 - ANSWER safety, effectiveness, and dosage range clinical trials 4 - ANSWER post marketing When can drugs be prescribed to the general public - ANSWER after it pass phase 3 What do control substance schedule mean? - ANSWER abuse and dependency Which pregnancy class is safe to use - ANSWER class Awhich pregnancy class you should never use - ANSWER class X How do genetic polymorphism impact drug therapy - ANSWER changes to DNA outside the nucleus to determine the treatment outcome of a pharmacologic agent Generic drug name - ANSWER safest, FDA approve, unique trade name - ANSWER can be more than one, pharmaceutical name it drug formulation - ANSWER liquid and solids 4 pharmacokinetic processes - ANSWER Absorption Distribution Metabolism Elimination bioavailabilty - ANSWER extent of absorption effect of food and absorption - ANSWER slower absorption what is the issues with enteric coated tablets and time release medication - ANSWER do not chew or crush suspension vs solution - ANSWER suspension particles settle and you have to shake it and the solution is homogeneous Ionized vs nonionized form - ANSWER nonionized is easy to pass and ionized is hard to pass through lipid solubility - ANSWER easy to pass for absorption distribution to breast milk and placenta - ANSWER highways of drug transportation the protein that drugs bind to - ANSWER albumin < 3.0 albumine - ANSWER hypoalbuminemia when are drugs active - ANSWER when they are free drugs